Results 51 to 60 of about 808,226 (293)

“Fabriquer l’hospitalité tout contre la ville hostile”

, 2023
Au cours de l’atelier “Reconsidérer l’urbanisme en toute hospitalité”, organisé dans le cadre de la 26e Université d’été du CFDU à Grenoble, l’architecte Sébastien Thiéry a présenté l’activité engagée et innovante du Pôle d’exploration des ressources ...
Revue d'urbanisme Diagonal
core  

Association Between Individualized Education for Kidney Replacement Therapy Modality Selection and Peritoneal Dialysis Initiation: A Cross‐Sectional Study

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Peritoneal dialysis (PD) is an established home‐based kidney replacement therapy (KRT), but its uptake remains low in Japan. We evaluated whether individualized education in a dedicated outpatient clinic was associated with the initiation of PD.
Yasuko Ito, Ryuichi Yoshimura, Takaki Yamauchi, Yuta Funakoshi, Hirotaka Sonoda, Seiji Kobayashi, Hiroyuki Terawaki, Takafumi Ito   +7 more
wiley   +1 more source

Mutual neighbors and diagonal loading-based sparse locally linear embedding

Applied Artificial Intelligence, 2018
In this study, a new Locally Linear Embedding (LLE) algorithm is proposed. Common LLE includes three steps. First, neighbors of each data point are determined.
Rassoul Hajizadeh, Ali Aghagolzadeh, Mehdi Ezoji   +2 more
doaj   +1 more source

Fully automatic computation of diagonal loading levels for robust adaptive beamforming

2008 IEEE International Conference on Acoustics, Speech and Signal Processing, 2008
One of the most well-known robust adaptive beamforming approaches is diagonal loading. However, there are usually no clear guidelines on how to choose the diagonal loading level reliably. In this paper, we present algorithms that can compute the diagonal loading level fully automatically from the given data without the need of specifying any user ...
Jian Li, , Lin Du, , Petre Stoica,
openaire   +2 more sources

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

La parole à Sébastien Thiéry, coordinateur des actions du PEROU

, 2022
Au cours de l’atelier "Reconsidérer l’urbanisme en toute hospitalité", organisé dans le cadre de la 26ème Université d'été du CFDU à Grenoble (lire l'article consacré), l’architecte Sébastien Thiéry a présenté l’activité engagée et innovante du Pôle d ...
Revue d'urbanisme Diagonal
core  

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source