Results 91 to 100 of about 3,965,801 (321)

BIT-MODULAR PRESENTATION COMPLEX TECHNICAL SYSTEMS AND PROBLEM SOLVING ANALYSIS OF THEIR CONDITION

open access: yesВестник Дагестанского государственного технического университета: Технические науки, 2016
The article deals with the analysis of a new object, called a system with bitmodular organization for which to solve the problem of monitoring and diagnosing.
M. M. Kanaev, K. D. Kurbanmagomedov
doaj   +1 more source

A V-Diagram for the Design of Integrated Health Management for Unmanned Aerial Systems [PDF]

open access: yes, 2015
Designing Integrated Vehicle Health Management (IVHM) for Unmanned Aerial Systems (UAS) is inherently complex. UAS are a system of systems (SoS) and IVHM is a product-service, thus the designer has to take into account many factors, such as: the design ...
BAE Systems   +5 more
core  

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

open access: yesMolecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes   +20 more
wiley   +1 more source

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

open access: yesMolecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser   +11 more
wiley   +1 more source

Transforming timing diagrams into knowledge acquisition in automated specification

open access: yes, 2007
Requirements engineering is an important part of developing programs. It is an essential stage of the software development process that defines what a product or system should to achieve.
Joochim, Tossaporn, Poppleton, Mike
core  

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

open access: yesMolecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani   +14 more
wiley   +1 more source

Diagrams of *-Trisections

open access: yes, 2019
In this note, we provide a generalization for the definition of a trisection of a 4-manifold with boundary. We demonstrate the utility of this more general definition by finding a trisection diagram for the Cacime Surface, and also by finding a trisection-theoretic way to perform logarithmic surgery. In addition, we describe how to perform 1-surgery on
Aranda, J., Moeller, J.
openaire   +3 more sources

Tonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages

open access: yesMolecular Oncology, EarlyView.
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez   +17 more
wiley   +1 more source

An Unknotting Index for Virtual Links

open access: yes, 2018
Given a virtual link diagram $D$, we define its unknotting index $U(D)$ to be minimum among $(m, n)$ tuples, where $m$ stands for the number of crossings virtualized and $n$ stands for the number of classical crossing changes, to obtain a trivial link ...
Kaur, Kirandeep   +2 more
core  

Expression and DNA methylation of 20S proteasome subunits as prognostic and resistance markers in cancer

open access: yesMolecular Oncology, EarlyView.
Comprehensive analysis of genomic mutations, gene expression, DNA methylation, and pathway analysis of TCGA data was carried out to define cancer types in which proteasome subunits expression is associated with worse survival. Albeit the effect of specific proteasome subunits on cellular function, the main role of the proteasome is better evaluated ...
Ruba Al‐Abdulla   +5 more
wiley   +1 more source

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