Results 101 to 110 of about 3,965,801 (321)

The diagram for phyllotactic series

open access: yesActa Societatis Botanicorum Poloniae, 2014
Many authors studying phyllotaxis in various plant species have reported the occurrence of many different numbers of contact parastichy pairs that are members of different Fibonacci-like series.
Joanna Szymanowska-Pułka   +1 more
doaj   +1 more source

Detecting homologous recombination deficiency for breast cancer through integrative analysis of genomic data

open access: yesMolecular Oncology, EarlyView.
This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu   +12 more
wiley   +1 more source

Data‐driven discovery of gene expression markers distinguishing pediatric acute lymphoblastic leukemia subtypes

open access: yesMolecular Oncology, EarlyView.
This study investigates gene expression differences between two major pediatric acute lymphoblastic leukemia (ALL) subtypes, B‐cell precursor ALL, and T‐cell ALL, using a data‐driven approach consisting of biostatistics and machine learning methods. Following analysis of a discovery dataset, we find a set of 14 expression markers differentiating the ...
Mona Nourbakhsh   +8 more
wiley   +1 more source

Comprehensive omics‐based classification system in adult patients with B‐cell acute lymphoblastic leukemia

open access: yesMolecular Oncology, EarlyView.
The COMBAT classification system, developed through multi‐omics integration, stratifies adult patients with B‐cell acute lymphoblastic leukemia(B‐ALL) into three molecular subtypes with distinct surface antigen patterns, immune landscape, methylation patterns, biological pathways and prognosis.
Yang Song   +11 more
wiley   +1 more source

Deformations of Diagrams

open access: yes, 2014
In this this paper we introduce entanglement among the points in a non-commutative scheme, in addition to the tangent directions. A diagram of $A$-modules is a pair $\uc=(|\uc|, )$ where $|\uc|={V_1,...,V_r}$ is a set of $A$-modules, and $ =\{ _{ij}(l)\}$ is a set of $A$-module homomorphisms $ _{ij}(l):V_i\rightarrow V_j$, seen as the 0'th order ...
openaire   +3 more sources

On Heegaard Diagrams [PDF]

open access: yesMathematical Research Letters, 1997
Let \(h\) be a homeomorphism of a handlebody \(H\) to itself. If the restriction of \(h\) to the boundary \(\partial H\) of \(H\) is a product of Dehn twists along a system of pairwise disjoint curves in \(H\), then it is shown that every one of the curves must bound a disc in \(H\).
openaire   +1 more source

Circulating tumor DNA monitoring and blood tumor mutational burden in patients with metastatic solid tumors treated with atezolizumab

open access: yesMolecular Oncology, EarlyView.
In patients treated with atezolizumab as a part of the MyPathway (NCT02091141) trial, pre‐treatment ctDNA tumor fraction at high levels was associated with poor outcomes (radiographic response, progression‐free survival, and overall survival) but better sensitivity for blood tumor mutational burden (bTMB).
Charles Swanton   +17 more
wiley   +1 more source

Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma

open access: yesMolecular Oncology, EarlyView.
GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski   +19 more
wiley   +1 more source

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