Results 61 to 70 of about 4,142,479 (322)

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Automatic extraction of corollaries from semantic structure of text

Open Engineering, 2016
The aim of this study is to develop an algorithm for automatic representation of the text of natural language as a formal system for the subsequent automatic extraction as reasonable answers to profound questions in the context of the text, and the deep ...
Nurtazin Abyz T., Khisamiev Zarif G.
doaj   +1 more source

A Diagram Is Worth A Dozen Images

, 2016
Diagrams are common tools for representing complex concepts, relationships and events, often when it would be difficult to portray the same information with natural images.
B Alexe, CL Zitnick, F Pedregosa, J von Engelhardt, JRR Uijlings, M Twyman, R Horn, R Koncel-Kedziorski, RK Srihari, RW Ferguson, S Antol, S Hochreiter, SC Zhu, SK Card   +13 more
core   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Normatividad entre esteticidad y tecnicidad según Simondon: hacia una Estética del Derecho como Mecanología de las normas jurídicas

ARS, 2019
RESUMEN En el presente trabajo proponemos un abordaje del fenómeno de la normatividad al que llamamos Estética del Derecho. Nos basamos, para ello, en la propuesta de una Mecanología utilizada por Gilbert Simondon para abordar el fenómeno de la ...
Gonzalo S. Aguirre
doaj   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Diagramming the Topology of Technology and Architecture in the 21st Century

Journal of Architectural Sciences and Applications
The research aims to address the existence of neoliberal policies in contemporary architectural production from an onto-political perspective. In Deleuze's ontology, the movement between the self and the other is established between the architect-subject
Tolga Sayın, Asude Yokuş
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Exchange Currents for Hypernuclear Magnetic Moments

, 1997
The meson(K and $\pi$) exchange currents for the hypernuclear magnetic moments are calculated using the effective Lagrangian method. The seagull diagram, the mesonic diagram and the $\Sigma^0$-excitation diagram are considered.
Ajimura, Ajimura, Arima, Arima, Arima, Arima, Blin-Stoyle, Chemtob, Dover, Dover, Fukuda, Hyuga, Ichimura, K. Saito, M. Oka, Mathiot, Nagels, Nakai, Noya, Povh, Shimizu, T. Suzuki, Towner, Yamamoto, Yamazaki, Yamazaki   +25 more
core   +2 more sources

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source