Results 121 to 130 of about 1,358 (267)

Divergent Roles of mGlu2 and mGlu3 Receptors in Amyloid‐β Production and Cognitive Dysfunctions in Alzheimer's Disease

Advanced Science, EarlyView.
This study explores the opposing effects of the mGluR2 and mGluR3 receptors on amyloid precursor protein processing. mGluR2 promotes amyloidogenic cleavage, while mGluR3 favors non‐amyloidogenic pathways. Using a brain‐penetrant nanobody as a mGluR2 positive allosteric modulator, the study uncovers how its chronic activation aggravates amyloid‐β burden
Pierre‐André Lafon, Mireille Elodie Tsitokana, Ugo Guy Alenda, Yen‐Ling Lian, Clémentine Eva Philibert, Mathieu Oosterlaken, Marta Cimadevila, Gaëlle Dudon, Jessica Monnic, Salomé Roux, Julie Bessié, Séverine Diem, Franck Vandermoere, Laurent Prézeau, Patrick Chames, Julie Kniazeff, Sylvie Claeysen, Anaïs Menny, Jean‐Philippe Pin, Véronique Perrier, Jianfeng Liu, Philippe Rondard   +21 more
wiley   +1 more source

Lyophilized Synthetic Platelets: In Vitro Characterization and in Vivo Evaluation in Mouse Thrombocytopenia Model

Advanced Science, EarlyView.
ABSTRACT Platelet transfusions to treat bleeding complications use donor‐derived platelets stored at room‐temperature, that have a shelf‐life of only 5–7 days due to bacterial contamination risks. Cold‐stored and freeze‐dried platelets are being investigated for extending shelf‐life, but these still have the inherent challenge of donor‐dependency.
Ujjal Didar Singh Sekhon, Dante Disharoon, Shrijal S. Desai, Baylee Traylor, Emily Gahagan, Emma Quill, Kristin Aldridge, Norman F. Luc, Sonali Rohiwal, Shruti Raghunathan, Rebecca Ahn, Sana Syed, Alexander Dornback, Bipin Chakravarthy Paruchuri, Andrew Ditto, Susan M. Shea, Philip C. Spinella, Matthew D. Neal, Michael A. Bruckman, Christa L. Pawlowski, Anirban Sen Gupta   +20 more
wiley   +1 more source

Le temps du travail dans le temps de l'emploi: Biographies professionnelles et bibliographies familiales d'infirmières de plus de 40 ans

, 2004
Post-enquête "Conditions et organisation du travail dans les établissements de santé"La recherche ici présentée est l'une des « post-enquêtes » financées par la DREES dans la foulée de sa vaste enquête sur les « conditions et l'organisation du travail ...
Bouffartigue, Paul, Bouteiller, Jacques
core   +2 more sources

Quantifying Missed Opportunities for Recruitment to Home Dialysis Therapies. [PDF]

Can J Kidney Health Dis, 2021
Poinen K, Er L, Copland MA, Singh RS, Canney M.   +4 more
europepmc   +1 more source

Biomimetic Polymerization of Tellurocysteine: Breaking the Natural Amino Acid Radioprotection Limitation

Advanced Science, EarlyView.
Inspired by natural amino acid polymer‐melanin systems, this study strategically incorporated tellurocysteine to develop advanced radiation‐shielding materials. This approach transformed the primary interaction mechanism between melanin‐based materials and incident photons from Compton scattering to the photoelectric effect. Tellurocysteine‐polymerized
Wei Chen, Hanjie Zhu, Yue Zhang, Yuqing Qiao, Ruotong Deng, Huaping Xu, Wei Cao   +6 more
wiley   +1 more source

L'efficacité du marché des organes : Hypothèse théorique ou validité pratique ? [PDF]

, 2009
Les organes en tant que ressources thérapeutiques sont par essence rares et peuvent donc être considérés comme des biens économiques à part entière. L'Etat est actuellement l'institution dominante d'allocation de ces ressources et les transferts sont ...
Sambuc, Cléa
core   +2 more sources

A Biomimetic Lubricant Captures Hyaluronic Acid In Situ to Regenerate Cartilage: From Bench to Bedside

Advanced Science, EarlyView.
(a) The outstanding lubricative properties of natural articular cartilage arise from a composite coating composed of HA, lubricin, and phospholipids at its surface. Notably, lubricin facilitates the enrichment of synovial HA onto cartilage surfaces, and HA complexes with phospholipids, a key component to maintain extremely low friction under high ...
Yongan Lin, Zijian Yan, Jiayi Chen, Xiaochao Wang, Ruibin Lin, Yunqi Fu, Zhaoying Lv, Bohui Wu, Xuewei Cao, Renjian Xie, Ming Dong, Chenxiao Zheng, Li Ren   +12 more
wiley   +1 more source

Le patient comme 1er partenaire du parcours MRC. Une évidence à l’épreuve du temps

Bulletin de la Dialyse à Domicile
Le parcours MRC est ponctué d’allers-retours multiples que ce soit du service de pédiatrie vers le service adulte, vers l’entrée en suppléance, d’une technique de suppléance à l’autre, du domicile à l’institution, parfois jusqu’à la fin l’arrêt de ...
Sandrine Letrecher
doaj   +1 more source

[Role of the French national registry REIN in the health monitoring of patients with end-stage chronic renal failure infected with SARS-CoV-2: Organization and initial data]. [PDF]

Nephrol Ther, 2021
Lapalu S, Izaaryene G, Honoré N, Couchoud C, registre REIN.   +4 more
europepmc   +1 more source

An education initiative modifies opinions of hemodialysis nurses towards home dialysis [PDF]

, 2015

core   +1 more source