Clotrimazole‐loaded PLGA microparticles for local drug delivery to the vagina: Shape does matter
Animal Models and Experimental Medicine, EarlyView.Clotrimazole‐loaded PLGA microparticles for intravaginal delivery. Abstract Background Intravaginal drug administration is the most promising strategy for treating vaginal infections to protect women's health, such as vulvovaginal candidiasis (VVC). However, conventional vaginal formulations in the clinic face challenges such as drug leakage and low ...
Yanyu Li +8 more
wiley +1 more source
Liposomal Delivery of L‐2‐Hydroxyglutarate for Targeting Epigenetic Dysregulation in Osteoarthritis
Advanced NanoBiomed Research, EarlyView.Osteoarthritis involves cartilage degeneration, inflammation, and epigenetic dysregulation. A liposomal formulation of the TET1 inhibitor L‐2‐hydroxyglutarate to overcome rapid joint clearance was developed. The formulation showed good physicochemical properties, reduced inflammatory and catabolic gene expression in chondrocytes, and alleviated ...
Denise Murgia +10 more
wiley +1 more source
Apport du Web sémantique au travail collaboratif : Application à l'édition d'un document d'information sur les risques majeurs [PDF]
, 2014 http://www.irit.fr/~Guillaume.Cabanac/docs/fjc2014/fjc2014actes.pdf" Collaborer " , " travailler ensemble " , ce sont des réalités familières à chacun d'entre nous.
Brun, Valentin
core +1 more source
Advanced NanoBiomed Research, EarlyView.This study presents a multifunctional Baghdadite ceramic implant integrating doxorubicin‐loaded liposomes via ion‐assisted plasma polymer coating for localized osteosarcoma therapy. The platform enables drug retention, sustained release, tumor cell inhibition, osteoconductivity, and antibacterial activity, offering a mechanically robust strategy for ...
Sally Kortam +8 more
wiley +1 more source
The WISHED Randomized Controlled Trial: Impact of an Interactive Health Communication Application on Home Dialysis Use in People With Chronic Kidney Disease. [PDF]
Can J Kidney Health Dis, 2021 Molnar AO +5 more
europepmc +1 more source
Comparaison entre l'effet de l'activité physique d'endurance et de renforcement chez les patients atteints du Syndrome métabolique: une revue de littérature : travail de Bachelor [PDF]
, 2014 Introduction : Le Syndrome métabolique (Smet) est une problématique capitale car il prédispose à certaines maladies chroniques telles que le diabète de type 2 ou les maladies cardiovasculaires.
Allet, Lara, Morard, Lisa, Piccot, Rémi
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Intravenous lanadelumab for the treatment of moderately ill COVID‐19 patients
British Journal of Clinical Pharmacology, EarlyView.Aims Kallikrein‐kinin system (KKS) dysregulation is hypothesized to play a pathogenetic role in COVID‐19‐associated pulmonary oedema. To investigate the efficacy and safety of intravenous lanadelumab, a monoclonal antibody that inhibits plasma kallikrein, in COVID‐19, we conducted a phase 2, open‐label, randomized‐controlled, proof‐of‐concept ...
Job J. Engel +12 more
wiley +1 more source
BMEMat, EarlyView.This article introduces a biomimetic Mn‐doped polydopamine nanoplatform (HAMM NPs) coated with cancer cell membranes. It enables targeted hepatocellular carcinoma theranostics via T1/T2 dual‐mode magnetic resonance imaging and tumor microenvironment‐triggered sonodynamic therapy/chemodynamic therapy, achieving potent antitumor efficacy in subcutaneous ...
Jiayin Lin +7 more
wiley +1 more source
Définition des priorités sanitaires et rationnement. L'opinion des Suisses, des Administrateurs hospitaliers et des Départements sanitaires des Cantons. [PDF]
Objectifs. Le but de cette analyse est,[i] de présenter l'opinion actuelle de la population suisse sur des thèmes liés à la limitation des ressources, à la définition des priorités et au rationnement dans le secteur sanitaire, [ii] de comparer cette ...
Gianfranco DOMENIGHETTI, Jenny MAGGI
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