Results 171 to 180 of about 478 (217)

Update on the Pathophysiology, Aetiology and Management of Central Sleep Apnoea

Respirology, EarlyView.
ABSTRACT Central sleep apnoea (CSA) of the periodic breathing type occurs during the transition between wakefulness and stage 1 and 2 non‐REM sleep. In adults at sea level, it occurs most commonly due to advanced heart failure (HF) or chronic opioid use and in ~5% of obstructive sleep apnoea patients initiating CPAP.
Sahan D. Chandrasekara, Matthew T. Naughton   +1 more
wiley   +1 more source

Survival Comparisons of Home Dialysis Versus In-Center Hemodialysis: A Narrative Review. [PDF]

Can J Kidney Health Dis, 2019
Vinson AJ, Perl J, Tennankore KK.
europepmc   +1 more source

Reactivity of Oxidized Porous Silicon with Calcium Ion in Aqueous Media: Stability, pH Behavior, and Host‐Guest Strategies

Small, EarlyView.
Oxidized porous silicon, composed of an elemental silicon porous skeleton coated with a silica shell, reacts with aqueous Ca2+ to generate a mixed silica–calcium silicate matrix that is remarkably efficient at trapping small molecules. With an emphasis on the engineering of controlled‐release drug delivery systems, this study identifies the factors ...
Ruhan Fan, Qinglin Yang, Michael J. Sailor   +2 more
wiley   +1 more source

Polymersome‐Enabled Multimodal Delivery of Tobramycin and Doripenem for Targeted Eradication of Pseudomonas aeruginosa Biofilms in Chronic Rhinosinusitis

Small, EarlyView.
Schematic representation of diffusion‐based versus pH‐triggered drug release within a bacterial biofilm. In diffusion‐based systems, drug cargo is gradually released independent of local pH, resulting in rapid burst release and reduced sustained concentrations.
Amalie Kjær Andresen, Matteo Tollemeto, Alexander B. Cook, Claus Sternberg, Yudong Li, Claus Moser, Lars Jelsbak, Jan C. M. Van Hest, Anja Boisen, Line Hagner Nielsen   +9 more
wiley   +1 more source

Dual‐Stimuli Responsive Poly(N‐acryloyl glycine) Microgels: Investigation of Network Structures and Application for Loading and Release of Biologics

Small, EarlyView.
Poly(N‐acryloyl glycine) hydrogel microparticles were fabricated via droplet‐based microfluidics and in situ photopolymerization. Rheology and MQ‐NMR revealed pronounced effects of pH and Ca2+ on network constraints and chain mobility, governing extensive swelling.
Yusuf Dursun, Burak Aydin, Bidit Lamsal, Deniz Ceylan, Kay Saalwächter, Christian Wischke   +5 more
wiley   +1 more source

A Current State of the Art and Science of Exercise in Dialysis: A Narrative Review. [PDF]

Can J Kidney Health Dis
Borkum M, Levin A, Ficocelli J, Wone L, Kiaii M.   +4 more
europepmc   +1 more source

Redox‐responsive dual‐drug nanomedicine integrating cisplatin and trypsin for synergistic reversal of tumor chemoresistance

Smart Molecules, EarlyView.
This study presents a novel glutathione‐activatable prodrug nanomedicine (cRGD‐PEG‐PGlu‐NP (ssTrypsin & CDDP)) that co‐encapsulates cisplatin and a masked protease to combat cisplatin resistance. The dual‐drug system selectively targets resistant tumor cells, enhancing the efficacy of cisplatin while minimizing systemic toxicity.
Xiaolan Yin, Qi Wang, Ming Zhang, Cheng Zhang, Qixian Chen, Haidong Li, Yan Zhao, Yue Wang, Jingyun Wang, Liuwei Zhang, Hongyan Cui   +10 more
wiley   +1 more source

Endocytosis‐independent cytosolic entry of messenger RNA via fluorous bilayer zippering attenuating Toll‐like receptor signaling and enables ischemic tissue salvage

Smart Molecules, EarlyView.
The present study establishes a paradigm shift in synthetic mRNA delivery through the convergence of three orthogonal chemistries—perfluoro‐acylation, bio‐orthogonal click cross‐linking, and disulfide reduction—within a single, modular polymer architecture. Abstract A fundamental constraint of conventional messenger RNA (mRNA) delivery systems is their
Yue Wang, Haitao Xie, Guoqing Xiang, Yanhua Li, Changgui Tong, Hongyan Cui, Qixian Chen, Haidong Li, Yan Zhao   +8 more
wiley   +1 more source

[OverView of infectious and non-infectious diseases in French Polynesia in 2025]. [PDF]

Med Trop Sante Int
Oehler E, Mayan R, Lastère S, Ségalin JM, Remaudière B, Nguyen L, Debacre J, Condat B, Cao-Lormeau VM, Bossin H, Gatti Howell C, Jullien M, Nunez S, Delaval R, Buon R, Richaud R, Parrat É, Sauget S, Gustin P, Botche SL, Genet P, Sebti J, Rereao M, Durand L, Dupire P, Butaud JF, Thomas C, Epelboin L.   +27 more
europepmc   +1 more source