Results 31 to 40 of about 28,431 (153)

Increased SOD2 in the diaphragm contributes to exercise-induced protection against ventilator-induced diaphragm dysfunction

Redox Biology, 2019
Mechanical ventilation (MV) is a life-saving intervention for many critically ill patients. Unfortunately, prolonged MV results in rapid diaphragmatic atrophy and contractile dysfunction, collectively termed ventilator-induced diaphragm dysfunction (VIDD)
Aaron B. Morton, Ashley J. Smuder, Michael P. Wiggs, Stephanie E. Hall, Bumsoo Ahn, J. Matthew Hinkley, Noriko Ichinoseki-Sekine, Andres Mor Huertas, Mustafa Ozdemir, Toshinori Yoshihara, Nicholas R. Wawrzyniak, Scott K. Powers   +11 more
doaj   +1 more source

Lymphatic Abnormalities in Noonan Syndrome Extend Beyond Clinically Apparent Disease

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Lymphatic disease represents a well‐described manifestation of Noonan syndrome (NS), yet the full phenotypic spectrum remains incompletely characterized, especially in asymptomatic individuals. We conducted a cross‐sectional study including 10 individuals with NS (four with peripheral lymphedema and six without) and 10 age‐ and sex‐matched ...
Inger Norlyk Sheyanth, Benjamin Kelly, Sheyanth Mohanakumar, Steffen Ringgaard, Yoav Dori, Irene Kibæk Nielsen, Uffe Birk Jensen, Vibeke Elisabeth Hjortdal   +7 more
wiley   +1 more source

Transcutaneous electrical diaphragmatic stimulation in mechanically ventilated patients: a randomised study

Critical Care, 2023
Background Few specific methods are available to reduce the risk of diaphragmatic dysfunction for patients under mechanical ventilation. The number of studies involving transcutaneous electrical stimulation of the diaphragm (TEDS) is increasing but none ...
Clément Medrinal, Margaux Machefert, Bouchra Lamia, Tristan Bonnevie, Francis-Edouard Gravier, Roger Hilfiker, Guillaume Prieur, Yann Combret   +7 more
doaj   +1 more source

Sepsis Disrupts Mitochondrial Function and Diaphragm Morphology

Frontiers in Physiology, 2021
BackgroundThe diaphragm is the primary muscle of inspiration, and its dysfunction is frequent during sepsis. However, the mechanisms associated with sepsis and diaphragm dysfunction are not well understood.
Thamires Siqueira Oliveira, Anderson Teixeira Santos, Cherley Borba Vieira Andrade, Johnatas Dutra Silva, Natália Blanco, Nazareth de Novaes Rocha, Juliana Woyames, Pedro Leme Silva, Patricia Rieken Macedo Rocco, Wagner Seixas da-Silva, Tânia Maria Ortiga-Carvalho, Flavia Fonseca Bloise   +11 more
doaj   +1 more source

Three‐dimensional geometric morphometric analysis of diaphragmatic dome motion in COPD patients

The Anatomical Record, EarlyView.
Abstract Diaphragmatic dysfunction is a hallmark of chronic obstructive pulmonary disease (COPD), especially in emphysema, where hyperinflation alters diaphragm geometry and impairs inspiratory mechanics. However, quantitative three‐dimensional (3D) assessments of diaphragmatic dome shape and motion across COPD phenotypes are limited.
José M. López‐Rey, Benoît Beyer, Elena García‐Vargas, Isabel Torres‐Sánchez, Francisco García‐Río, Markus Bastir   +5 more
wiley   +1 more source

Human evolution and the obstetrical dilemma: The pelvic floor hypothesis

The Anatomical Record, EarlyView.
Abstract Human childbirth is mechanically difficult because a large‐headed, broad‐shouldered fetus must pass through a comparatively narrow, twisted bony birth canal. Traditional explanations of this “obstetrical dilemma” emphasize the role of bipedal locomotion in inhibiting the evolution of a wider, more spacious pelvis.
Barbara Fischer, Ekaterina Stansfield
wiley   +1 more source

Is Mitochondrial Oxidative Stress the Key Contributor to Diaphragm Atrophy and Dysfunction in Critically Ill Patients?

Critical Care Research and Practice, 2020
Diaphragm dysfunction is prevalent in the progress of respiratory dysfunction in various critical illnesses. Respiratory muscle weakness may result in insufficient ventilation, coughing reflection suppression, pulmonary infection, and difficulty in ...
Hongjie Duan, Hailiang Bai
doaj   +1 more source

Retrieval Practice Through an Integrated Anatomy Laboratory Experience in a Doctor of Physical Therapy Curriculum

Clinical Anatomy, EarlyView.
ABSTRACT Gross anatomy is a foundational first‐year component of Doctor of Physical Therapy (DPT) curriculum, with limited future vertical integration. Retrieval practice and spaced learning to enhance retention are rarely embedded in second‐year DPT coursework.
Christina M. Cuka, Kellie C. Huxel Bliven, Emilio J. Puentedura   +2 more
wiley   +1 more source

Motility Analysis of Diaphragm in Patients With Chronic Pulmonary Lung Disease Based on Computed Tomography Technique

IEEE Access, 2023
The diaphragm plays a crucial role in respiration, and diaphragm dysfunction is common in COPD, contributing to worsening symptoms and higher mortality rates.
Hao Yu, Nnubia Pascal Nnamdi, Aria Seo, Jinkyeong Park, Yunsik Son   +4 more
doaj   +1 more source

Interventional therapies for chronic heart failure: An overview of recent developments

ESC Heart Failure, Volume 12, Issue 2, Page 1081-1094, April 2025.
Abstract Heart failure (HF), the final manifestation of most cardiovascular diseases, has become a major global health concern, affecting millions of individuals. Despite basic drug treatments, patients present with high morbidity and mortality rates. However, recent advancements in interventional therapy have shown promising results in improving the ...
Bingchen Guo, Si Shi, Yutong Guo, Jie Xiong, Bo Wang, Zengxiang Dong, Dianyu Gao, Yingfeng Tu   +7 more
wiley   +1 more source