Results 41 to 50 of about 591,105 (206)

Nuclear Pore Mechanotransduction in Oncology: A Structural Axis of Vulnerability for Targeted Intervention

Advanced Materials, EarlyView.
Cancer‐associated NPC remodeling creates a high‐flux, low‐stringency nuclear state that supports malignant adaptation but increases mechanical fragility. Targeting the FG‐barrier or NPC scaffold may drive mechanostat failure, envelope rupture, DNA damage, and loss of nuclear integrity.
Sílvio Terra Stefanello, Caren Rigon Mizdal, Aline Franzen da Silva, Yun Qian, Wei‐En Yuan, Victor Shahin   +5 more
wiley   +1 more source

Cyclic Mechanical Loading of Cardiomyocytes via Pressure‐Driven Non‐Planar Membrane Deformation in a Bioreactor System

Advanced Science, EarlyView.
In this research article, Mansoor and coworkers present a novel device that applies controlled mechanical stimuli to cardiomyocytes using pressure‐driven membrane deformation. By exposing cells to physiologically and pathologically relevant loading conditions, the platform reproduces distinct structural, functional and molecular responses associated ...
Haris Mansoor, Gabrielle Juul, Jil Patel, Heran Pradhan, Gram Hepner, Jackson Jewell, Mark Bardin, Ryan Slusser, Abigail Glezer, Leda Klouda, Melikhan Tanyeri, Anita Saraf   +11 more
wiley   +1 more source

Transcutaneous electrical diaphragmatic stimulation in mechanically ventilated patients: a randomised study

Critical Care, 2023
Background Few specific methods are available to reduce the risk of diaphragmatic dysfunction for patients under mechanical ventilation. The number of studies involving transcutaneous electrical stimulation of the diaphragm (TEDS) is increasing but none ...
Clément Medrinal, Margaux Machefert, Bouchra Lamia, Tristan Bonnevie, Francis-Edouard Gravier, Roger Hilfiker, Guillaume Prieur, Yann Combret   +7 more
doaj   +1 more source

Diaphragmatic thickening fraction as a predictor for intubation in patients with COVID-19

Respiratory Medicine Case Reports, 2022
The diaphragm is the primary respiratory muscle, and its dysfunction predisposes patients to respiratory failure. Diaphragm function can be assessed by ultrasound measurement - Diaphragmatic Thickening Fraction (DTF).
Manuel Hache-Marliere, Hyomin Lim, Hassan Patail   +2 more
doaj   +1 more source

Spatiotemporal Multi‐Omic Mapping Reveals Liver‐Muscle Metabolic Crosstalk in Cancer Cachexia

Advanced Science, EarlyView.
The interactive CCAtlas platform delineates cross‐species, spatiotemporal, and sex‐specific molecular dynamics and metabolic rewiring across organs during cancer cachexia. Hepatic Gamt downregulation curtails hepatic creatine synthesis to trigger systemic creatine insufficiency and consequent skeletal muscle atrophy in LLC tumour‐bearing mice ...
Zihan Tian, Qianyu Wang, Wenyan Gao, Xianfeng Li, Jiawen Fan, Xiaoliang Wu, Siqi Liu, Xiangdong Ming, Danna Yeerken, Mutian Shen, Qingjie Min, Qimin Zhan, Yan Wang   +12 more
wiley   +1 more source

Endurance exercise attenuates ventilator-induced diaphragm dysfunction

, 2012
Controlled mechanical ventilation (MV) is a life-saving measure for patients in respiratory failure. However, MV renders the diaphragm inactive leading to diaphragm weakness due to both atrophy and contractile dysfunction.
Matthew B. Hudson, Kisuk Min, Oh-Sung Kwon, Ashley J. Smuder, Scott K. Powers, Andreas N. Kavazis, W. Bradley Nelson   +6 more
core   +1 more source

Baseline podocyte‐associated state and persistent cell–matrix transcriptional programs are associated with BALB/c substrain differences in adriamycin nephropathy

Animal Models and Experimental Medicine, EarlyView.
Two closely related BALB/c substrains exhibit different early responses to adriamycin (ADR)‐induced nephropathy. BALB/cByJcl mice showed lower baseline WT1‐positive nuclei counts and NPHS1 immunoreactivity than BALB/cAJcl mice, together with extracellular matrix and integrin programs that were enriched at baseline and persisted at Day 5.
Ryuya Nakagawa, Masaki Watanabe, Koyuki Kawamoto, Momoka Hiratsuka, Takeru Sasaki, Nobuya Sasaki   +5 more
wiley   +1 more source

Degrees of disclosure: a study of women's covert use of the diaphragm in an HIV prevention trial in sub-Saharan Africa.

, 2009
In sub-Saharan Africa more women are infected with HIV/AIDS than men and new prevention methods are urgently needed. One major attribute of female-initiated HIV prevention methods is that they can be used covertly, without a male partner's knowledge ...
van der Straten, Ariane, Montgomery, Elizabeth T, Padian, Nancy, Sahin-Hodoglugil, Nuriye Nalan, Kacanek, Deborah, Mtetwa, Sibongile, Morar, Neetha, MIRA Team, Munyoro, Jane, Cheng, Helen   +9 more
core   +1 more source

Sepsis Disrupts Mitochondrial Function and Diaphragm Morphology

Frontiers in Physiology, 2021
BackgroundThe diaphragm is the primary muscle of inspiration, and its dysfunction is frequent during sepsis. However, the mechanisms associated with sepsis and diaphragm dysfunction are not well understood.
Thamires Siqueira Oliveira, Anderson Teixeira Santos, Cherley Borba Vieira Andrade, Johnatas Dutra Silva, Natália Blanco, Nazareth de Novaes Rocha, Juliana Woyames, Pedro Leme Silva, Patricia Rieken Macedo Rocco, Wagner Seixas da-Silva, Tânia Maria Ortiga-Carvalho, Flavia Fonseca Bloise   +11 more
doaj   +1 more source

Ruxolitinib Prevents Ventilator Induced Diaphragm Dysfunction

, 2022
Mechanical ventilation (MV), however brief results in the loss of diaphragm muscle mass and strength, termed ventilator induced diaphragm dysfunction (VIDD).
Larsson, L,, Ruas, J,, Cacciani, N, Cacciani, Nicola,, Moruzzi, Noah,, Larsson, Lars,, Akkad, Hasem,, Addinsall, Alex B.,, Moruzzi, N, Bergquist, J, Addinsall, AB, Akkad, H, Shevchenko, Ganna,, Maestri, A, Shevchenko, G, Ruas, Jorge,, Bergquist, Jonas,, Maestri, Alice,   +17 more
core   +1 more source