Results 111 to 120 of about 20,082 (208)

Nonviral Gold Nanoparticle‐Mediated Delivery of CRISPR‐Cas9 Ribonucleoprotein and Long DNA Transgenes Into Primary Blood Cells

Advanced NanoBiomed Research, Volume 6, Issue 8, August 2026.
CRISPR/Cas9 has revolutionized the field of gene therapy, but delivery remains an outstanding issue. We propose a nonviral gold‐nanoparticle platform for co‐delivery of CRISPR/Cas9 ribonucleoprotein and long 2.1 kilobase dsDNA transgene constructs. This CRISPR‐AuNP is inexpensive to produce and mediate gene editing and DNA delivery in T cells and CD34+
Rachel A. Cunningham, Karthikeya S. V. Gottimukkala, Daniel D. Lane, Katrina Poljakov, Patricia Lipson, Mark R. Enstrom, Alessandro Rizzi, Aude G. Chapuis, Jennifer E. Adair   +8 more
wiley   +1 more source

Vaccination protocols in Québec dairy herds

Journal of Dairy Science
: Information is needed on vaccination protocols used by veterinarians and dairy producers to prevent and control infections in dairy herds. This observational study described farm's vaccination standard operating procedures (SOP) developed by ...
M.P. Morin, G. Fecteau, J.P. Roy, Marie-Ève Paradis, S. Dufour   +4 more
doaj   +1 more source

The Neuroprotective Potentials of Dual GIP/GLP1‐RA (Tirzepatide): From Preclinical Experiments to Clinical Trials: A Scoping Review

Brain and Behavior, Volume 16, Issue 8, August 2026.
The graphical abstract summarizes the current evidence on the potential neuroprotective effects of tirzepatide (TZP), a dual GIP/GLP‐1 receptor agonist, across mechanistic, preclinical, and clinical domains. Mechanistically, TZP is proposed to exert direct neural effects, preserve mitochondrial function, reduce apoptosis, oxidative stress, and ...
Yousef Hawas, Mohamed Abouzid, Ahmed Farid Gadelmawla, Dalia Kamal Ewis, Abdallah Khatatbeh, Yasmin Negida, Ahmed Negida   +6 more
wiley   +1 more source

Epidemy of Bovine Viral Diarrhea Virus 2 in Ishikawa Prefecture

Journal of the Japan Veterinary Medical Association, 1998
NAGAI, Makoto, GENNO, Akira, MURAKAMI, Toshiaki, TAKAI, Hikaru, UECHI, Masahide, AKASHI, Hiroomi   +5 more
openaire   +2 more sources

A Phase I/II Study of Ibrutinib Plus Trastuzumab in HER2‐Positive Metastatic Breast Cancer

Cancer Medicine, Volume 15, Issue 8, August 2026.
ABSTRACT Ibrutinib has demonstrated inhibition of ErbB/HER tyrosine kinases in preclinical models. This Phase I/II study investigated the safety, efficacy, and immunomodulatory effects of ibrutinib in combination with trastuzumab in patients with HER2‐positive metastatic breast cancer (MBC) whose disease had progressed on ado‐trastuzumab emtansine ...
Joyce O'Shaughnessy, Andrea Glidden, Tracy Locke, Amy Scales, Elizabeth Gatewood, Jean‐Philippe Blanck, Jessica Castaneda‐Gill, Sharlin Patel, Yolanda D. Mahnke, Xuan Wang, Page Blas   +10 more
wiley   +1 more source

Regional genetic diversity of bovine viral diarrhea virus in Ethiopia urban and peri-urban dairy farms

Scientific Reports
Bovine viral diarrhea (BVD) is a highly impactful disease in the cattle industry worldwide. The disease is caused by the Bovine Viral Diarrhea Virus (BVDV), a member of the genus Pestivirus within the Flaviviridae family.
Asamenew Tesfaye, Tesfaye Sisay Tessema, Ashenif Simachew, Demessa Negessu, Abde Aliy, Jan Paeshuyse   +5 more
doaj   +1 more source

Nanomaterial‐Based CRISPR/Cas‐Powered Electrochemical Sensing Integrated With Microfluidics for Rapid and Sensitive Diagnostics

Electrochemical Science Advances, Volume 6, Issue 4, August 2026.
ABSTRACT Rapid and sensitive detection of disease‐related biomarkers is critical for early diagnosis and appropriate treatment. However, conventional analytical methods are often time‐consuming and require complex procedures and skilled personnel.
Minju Ahn, Sang Baek Sim, Izzati Haizan, Jin‐Ha Choi, Jeong‐Woo Choi   +4 more
wiley   +1 more source

Targeted Interventions in HAM/TSP: Emerging Therapies and Future Directions – A Narrative Review

Health Science Reports, Volume 9, Issue 8, August 2026.
ABSTRACT Background and Aim Human T‐Lymphotropic virus type 1 (HTLV‐1) infection can lead to HTLV‐1‐associated myelopathy/tropical spastic paraparesis (HAM/TSP), a debilitating chronic neurological disease characterized by progressive lower limb spasticity and autonomic dysfunction.
Meygol Mirzaei Rezaei, Mahdi Khosravi Nia, Kasra Allaei Rouzbahani, Maryam Kazemi, Negar Asghari Hosori, Mehdi Norouzi, Farzaneh Sotoudegan, Narges Eslami, Negar Ariamand, Vahid Shahnavaz, Arash Letafati, Sayed‑Hamidreza Mozhgani   +11 more
wiley   +1 more source

Mycoplasma bovis involved in pituitary abscess syndrome in a beef heifer concomitantly infected with haemoparasites

Veterinary Record Case Reports, Volume 14, Issue 3, August 2026.
Abstract This case report describes pituitary abscess syndrome (PAS) in a 20‐month‐old Blonde d'Aquitaine heifer with cranial nerve deficits (V, VII, VIII, IX, X and XII) associated with facial hemiparesis, head tilt, ataxia and dysphagia, pneumonia and otitis interna.
Chloé Saada, Manon Gonçalves‐Brandao, Hortensia Robert, Renaud Maillard, Laurent‐Xavier Nouvel   +4 more
wiley   +1 more source

Bovine bacterial abortion caused by Escherichia coli infection

Veterinary Record Case Reports, Volume 14, Issue 3, August 2026.
Abstract A 3‐year‐old, 500 kg Holstein cow aborted at 7 months of gestation. On histological evaluation of the fetal lungs, abundant neutrophils infiltrated the alveolar spaces, bronchi and bronchioles with intralesional Gram‐negative bacteria, immunolabelled with Escherichia coli immunohistochemistry.
Jéssica Nathyelli da Silva, Daniel Felipe Barrantes Murillo, Augusto Cesar dos Santos Stering, Wuglenya Daislla Martins da Silva, Caroline Argenta Pescador   +4 more
wiley   +1 more source