Results 131 to 140 of about 1,327 (175)

Diarylheptanoids: Potent Anticancer Agents

Clinical Cancer Drugs, 2021
Abstract: Diarylheptanoids are widely distributed among species belonging to the family Betulaceae. Being highly polar in nature, they can either be isolated from plants by using sophisticated chromatographic techniques or can be synthesized in the laboratory.
Rabia Hameed
exaly   +2 more sources

Chemopreventive potential of cyclic diarylheptanoids

Bioorganic & Medicinal Chemistry, 2002
Eleven cyclic diarylheptanoids and seven related compounds were screened as potential antitumor promoters by using the in vitro short-term 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced Epstein-Barr virus early antigen (EBV-EA) activation assay. In addition, the cyclic diarylheptanoid myricanone (2) was examined for antitumor initiating activity in
Junko, Ishida, Mutsuo, Kozuka, Harukuni, Tokuda, Hoyoku, Nishino, Seiji, Nagumo, Kuo Hsiung, Lee, Masahiro, Nagai   +6 more
openaire   +2 more sources

Antihepatotoxic actions of gingerols and diarylheptanoids

Journal of Ethnopharmacology, 1985
The antihepatotoxic effects of gingerols, shogaols, diarylheptanoids and related analogues were assessed utilizing carbon tetrachloride- and galactosamine-induced cytotoxicity in primary cultured rat hepatocytes. Most congeners exhibited significant actions in these assay methods.
H, Hikino, Y, Kiso, N, Kato, Y, Hamada, T, Shioiri, R, Aiyama, H, Itokawa, F, Kiuchi, U, Sankawa   +8 more
openaire   +2 more sources

Diarylheptanoids of Centrolobium species

Phytochemistry, 1970
Abstract The heartwoods of two Centrolobium species (Leguminosae) were examined. C. robustum Mart. was found to contain piceatannol, (-)-centrolobine (VIIa), (-)-de- O -methylcentrolobine (VIIb) and (-)-centrolobol (VI). C. tomentosum Benth. was found to contain (+)-centrolobine (IXa), (+)-de- O -methylcentrolobine (IXb) and (+)-centrolobol ...
A. Aragão Craveiro, A. da Costa Prado, O.R. Gottlieb, P.C. Welerson de Albuquerque   +3 more
openaire   +1 more source

Diarylheptanoid: A privileged structure in drug discovery

Fitoterapia, 2020
Privileged structures are widely used in the process of drug design, and provide an effective template in medicinal chemistry. Diarylheptanoids are a class of structurally distinctive compounds with a wide variety of bioactivity, raising keenly interest in the past decades.
De-Juan, Sun, Ling-Juan, Zhu, Yu-Qian, Zhao, Yong-Qi, Zhen, Lan, Zhang, Cong-Cong, Lin, Li-Xia, Chen   +6 more
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Synthesis of a diarylheptanoid, (+)-centrolobine

Tetrahedron: Asymmetry, 2010
A chiron approach for the total synthesis of (+)-centrolobine has been described from the commercially available aldehyde 3 employing an acid-catalyzed stereoselective formation of tetrahydropyran ring as the key step. The desired molecule was accomplished in eight steps with 62% overall yield.
Ch. Raji Reddy, P. Phani Madhavi, S. Chandrasekhar   +2 more
openaire   +1 more source

Synthesis of gingerol and diarylheptanoids

Tetrahedron: Asymmetry, 2011
Abstract The synthesis of gingerol 1 and related compounds 2 – 5 along with diarylheptanoids 6 – 8 has been accomplished using a Keck allylation, Crimmins’ aldol reaction, aldehyde coupling with acetylene, and chelation controlled reductions as the key reactions.
Gowravaram Sabitha, Chitti Srinivas, Teega Rammohan Reddy, Kurra Yadagiri, Jhillu Singh Yadav   +4 more
openaire   +1 more source

New Diarylheptanoids and Diarylheptanoid Glucosides from the Rhizomes of Tacca chantrieri and Their Cytotoxic Activity

Journal of Natural Products, 2002
Two new diarylheptanoids (1, 2) and seven new diarylheptanoid glucosides (3-9) were isolated from the rhizomes of Tacca chantrieri. Their structures were determined by spectroscopic analysis, including 2D NMR data, and the results of hydrolytic cleavage.
Akihito, Yokosuka, Yoshihiro, Mimaki, Hiroshi, Sakagami, Yutaka, Sashida   +3 more
openaire   +2 more sources

Diarylheptanoids from the rhizomes of Zingiber officinale

Phytochemistry, 2004
Seven new diarylheptanoids, i.e., (3S,5S)-3,5-diacetoxy-1,7-bis(4-hydroxy-3-methoxyphenyl)heptane, (3R,5S)-3-acetoxy-5-hydroxy-1,7-bis(4-hydroxy-3-methoxyphenyl)heptane, (3R,5S)-3,5-dihydroxy-1-(4-hydroxy-3,5-dimethoxyphenyl)-7-(4-hydroxy-3-methoxyphenyl)heptane, (5S)-5-acetoxy-1,7-bis(4-hydroxy-3-methoxyphenyl)heptan-3-one, 5-hydroxy-1-(3,4-dihydroxy ...
Jianping, Ma, Xiaoling, Jin, Li, Yang, Zhong-Li, Liu   +3 more
openaire   +2 more sources

Diarylheptanoids from Alpinia officinarum

Journal of Asian Natural Products Research, 2006
A new diarylheptanoid, along with five known diarylheptanoids, was isolated from the rhizomes of Alpinia officinarum (Zingiberaceae). The structure of the new compound was determined to be trans,trans-1(3'-methoxy-4'-hydroxyphenyl)-7-phenyl-5-ol-4,6-dien-3-heptanone on the basis of spectral and chemical evidence.
N, An, L-Z, Xu, Z-M, Zou, S-L, Yang
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