Results 1 to 10 of about 581 (25)

Hemodynamics of a Bileaflet Mechanical Heart Valve with Different Levels of Dysfunction [PDF]

Volume 2 Issue 5 - 2017, 2017
Heart disease is one of leading causes of mortality worldwide. Healthy heart valves are key for proper heart function. When these valves dysfunction, a replacement is often necessary in severe cases. The current study presents an investigation of the pulsatile blood flow through a bileaflet mechanical heart valve (BMHV) where one leaflet is healthy and
arxiv   +1 more source

On in-silico estimation of left ventricular end-diastolic pressure from cardiac strains [PDF]

2024 46th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), pp. 1-4
Left ventricular diastolic dysfunction (LVDD) is a group of diseases that adversely affect the passive phase of the cardiac cycle and can lead to heart failure. While left ventricular end-diastolic pressure (LVEDP) is a valuable prognostic measure in LVDD patients, traditional invasive methods of measuring LVEDP present risks and limitations ...
arxiv   +1 more source

Methylglyoxal induces cardiac dysfunction through mechanisms involving altered intracellular calcium handling in the rat heart [PDF]

Chemico-Biological Interactions, 2024, 394, pp.110949
Methylglyoxal (MGO) is an endogenous, highly reactive dicarbonyl metabolite generated under hyperglycaemic conditions. MGO plays a role in developing pathophysiological conditions, including diabetic cardiomyopathy. However, the mechanisms involved and the molecular targets of MGO in the heart have not been elucidated.
arxiv   +1 more source

Delineation and Analysis of Seismocardiographic Systole and Diastole Profiles [PDF]

, 2020
Precise estimation of fiducial points of a seismocardiogram (SCG) signal is a challenging problem for its clinical usage. Delineation techniques proposed in the existing literature do not estimate all the clinically significant points of an SCG signal, simultaneously.
arxiv   +1 more source

Shared features of endothelial dysfunction between sepsis and its preceding risk factors (aging and chronic disease) [PDF]

, 2018
Acute vascular endothelial dysfunction is a central event in the pathogenesis of sepsis,increasing vascular permeability, promoting activation of the coagulation cascade, tissue edema and compromising perfusion of vital organs. Aging and chronic diseases(hypertension,dyslipidaemia,diabetes mellitus,chronic kidney disease,cardiovascular disease ...
arxiv   +1 more source

Computable Phenotypes to Characterize Changing Patient Brain Dysfunction in the Intensive Care Unit [PDF]

arXiv, 2023
In the United States, more than 5 million patients are admitted annually to ICUs, with ICU mortality of 10%-29% and costs over $82 billion. Acute brain dysfunction status, delirium, is often underdiagnosed or undervalued. This study's objective was to develop automated computable phenotypes for acute brain dysfunction states and describe transitions ...
arxiv  

Cognizance of Post-COVID-19 Multi-Organ Dysfunction through Machine Learning Analysis [PDF]

arXiv, 2023
In the year 2022, a total of 466 patients from various cities across Iraq were included in this study. This research paper focuses on the application of machine learning techniques to analyse and predict multi-organ dysfunction in individuals experiencing Post-COVID-19 Syndrome, commonly known as Long COVID. Post-COVID-19 Syndrome presents a wide array
arxiv  

A Wavelet Approach for the Estimation of Left Ventricular Early Filling Wave Propagation Velocity from Color-M-Mode Echocardiograms [PDF]

arXiv, 2019
Objective: This work evaluates a new approach for calculating the left-ventricular (LV) early filling propagation velocity (VP) from color M-Mode (CMM) echocardiograms using wavelet analysis. Unlike current approaches, the method requires no assumptions, user inputs, or heuristic conventions.
arxiv  

Medial Injury/Dysfunction Induced Granulation Tissue Repair is the Pathogenesis of Atherosclerosis [PDF]

arXiv, 2020
Atherosclerosis, a chronic lesion of vascular wall, remains a leading cause of death and loss of life years. Classical hypotheses for atherosclerosis are long-standing mainly to explain atherogenesis. Unfortunately, these hypotheses may not explain the variation in the susceptibility to atherosclerosis.
arxiv  

A coupled mitral valve -- left ventricle model with fluid-structure interaction [PDF]

arXiv, 2017
Understanding the interaction between the valves and walls of the heart is important in assessing and subsequently treating heart dysfunction. With advancements in cardiac imaging, nonlinear mechanics and computational techniques, it is now possible to explore the mechanics of valve-heart interactions using anatomically and physiologically realistic ...
arxiv