Results 91 to 100 of about 1,526,915 (347)

Topoisomerase 2B Decrease Results in Diastolic Dysfunction via p53 and Akt: A Novel Pathway

Frontiers in Cardiovascular Medicine, 2020
Diastolic dysfunction is condition of a stiff ventricle and a function of aging. It causes significant cardiovascular mortality and morbidity, and in fact, three million Americans are currently suffering from this condition.
Rohit Moudgil, Rohit Moudgil, Gursharan Samra, Kyung Ae Ko, Hang Thi Vu, Tamlyn N. Thomas, Weijia Luo, Jiang Chang, Anilkumar K. Reddy, Keigi Fujiwara, Jun-ichi Abe   +10 more
doaj   +1 more source

Relationship between coronary microvascular dysfunction and left ventricular diastolic function in patients with chest pain and unobstructed coronary arteries

, 2020
Backgroud: Diastolic dysfunction (DD) is reported to affect up to 35% of the adult general population. The consequence of progressive DD is heart failure with preserved ejection fraction (HFpEF).
Davies, Thomas, Greaves, Kim, Kim Greaves, Karen Nel, Nel, Karen, Tony Stanton, Christopher John Boos, Lam, Jeng Hwan, Boos, Christopher John, Quah, Jing Xian, Jeng Hwan Lam, Anstey, Christopher M., Thomas Davies, Anstey, Christopher M, Jing Xian Quah, Stanton, Tony, Christopher M. Anstey   +16 more
core   +1 more source

Synthetic MRI Neuroimaging Correlates of Frailty: Correlations Between Frailty Scales and Brain Structural Integrity

AGING MEDICINE, EarlyView.
Frailty was associated with decreased gray and white matter brain volumes in older adults. Synthetic MRI further revealed relaxometry alterations correlated with frailty severity across multiple clinical scales. ABSTRACT Objectives Frailty, a common condition in the elderly, is characterized by a decline in physiological reserves and an increased ...
Yuhui Chen, Fan Feng, Sicong Wang, Qi Wang, Hua Wang, Min Chen, Tao Gong, Chunmei Li   +7 more
wiley   +1 more source

Myocardial Mechanics in Patients With Normal LVEF and Diastolic Dysfunction.

JACC Cardiovascular Imaging, 2019
Heart failure with preserved ejection fraction (HFpEF) is a complex clinical entity that is poorly understood yet present in up to 5.5% of the general population.
C. Bianco, Peter D. Farjo, Y. Ghaffar, P. Sengupta   +3 more
semanticscholar   +1 more source

Genetic Risk and High Burden of Depression and Suicide in the Maya‐Mestizo Population of Yucatán, México

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, EarlyView.
ABSTRACT Major depression and suicide are critical public health concerns, particularly in underrepresented populations with unique genetic and sociocultural contexts. The Maya‐mestizo population presents the highest suicide rates in the country but remains understudied in psychiatric genetics. This study evaluated the association between three genetic
Marta Menjivar, Erandi Bravo, Margarita Rivera‐Balancan, Barbara Itzel Pena Espinoza   +3 more
wiley   +1 more source

Myocardial Performance Index (Tei Index): A simple tool to identify cardiac dysfunction in patients with diabetes mellitus

Indian Heart Journal, 2016
Background: Cardiac dysfunction is the major cause of morbidity and mortality in diabetes. Myocardial Performance Index (MPI/Tei Index) includes both systolic and diastolic time intervals to assess the global cardiac dysfunction.
Manjunath Goroshi, Dipti Chand
doaj   +1 more source

The impact of diastolic dysfunction as a predictor of cardiovascular events: A systematic review and meta-analysis.

Revista Portuguesa de Cardiologia, 2019
INTRODUCTION Diastolic dysfunction is highly prevalent and a key pathophysiological contributor to several cardiovascular diseases, especially heart failure with preserved ejection fraction.
R. Ladeiras-Lopes, M. Araújo, F. Sampaio, A. Leite-Moreira, R. Fontes‐Carvalho   +4 more
semanticscholar   +1 more source

Equine models in translational medicine: A comparative approach to human health

Animal Models and Experimental Medicine, EarlyView.
This diagram summarizes and contrasts rodent and equine models, outlining their strengths, limitations, and applications. Horses offer naturally occurring diseases, genetic and physiological similarities to humans, and suitability for longitudinal and clinical‐scale studies.
Shayan Boozarjomehri Amnieh, Katarzyna Ropka‐Molik   +1 more
wiley   +1 more source

Isolated Biventricular Noncompaction in an adult with severe pulmonary hypertension : an association reviewed. [PDF]

, 2012
Biventricular noncompaction is a recently recognized rare form of cardiomyopathy. It is characterized by altered structure of myocardial wall as a result of intrauterine arrest of compaction of the myocardial fibers in absence of coexisting congenital
Awasthy, Neeraj, Tomar, Munesh, Radhakrishnan, Sitaraman   +2 more
core  

The EuroHeart Failure survey programme—a survey on the quality of care among patients with heart failure in Europe Part 1: patient characteristics and diagnosis

, 2003
The European Society of Cardiology (ESC) has published guidelines for the investigation of patients with suspected heart failure and, if the diagnosis is proven, their subsequent management.
van Gilst, WH, Eastaugh, Joanne, Cohen-Solal, A., Gilst, W. H. van, Gavazzi, A, Freemantle, N, Cleland, JG, Gavazzi, A., Hobbs, Frederick, Moiseyev, VS, Dietz, R, van Gilst, W.H., Cleland, J.G., Hobbs, R, Korewicki, J., Follath, F., Hobbs, R., Mason, J., Eastaugh, J, Cohen-Solal, A, Préda, István, Cleland, JGF, Freemantle, Nick, Madeira, HC, Widimsky, J, Swedberg K Follath, F, Dietz, R., Cleland, J. G. F., Widimsky, J., Swedberg, K, Eastaugh, J., Preda, [No Value], Madeira, H. C., Moiseyev, V. S., Aguilar, JC, Aguilar, J.C., Komajda, M., Freemantle, N., Komajda, M, Preda, I., Korewicki, J, Aguilar, J. C., Mason, J, Madeira, H.C., Preda, I, Moiseyev, V.S., Swedberg, K., Follath, F   +47 more
core   +1 more source