Results 71 to 80 of about 1,526,915 (347)

Extracellular Vesicles Modulation by an Adiponectin Receptor Agonist Provides Cardioprotection for Myocardial Ischemic Injury

Advanced Healthcare Materials, EarlyView.
This study demonstrates that ALY688, a drug mimicking the heart‐protective hormone adiponectin, reduces myocardial ischemia injury. ALY688 increases the production of extracellular vesicles, which carry protective cargo including adiponectin itself.
Jialing Tang, Wing Yan Chung, Serena M. Pulente, Yubin Lei, Khang Nguyen, Eddie Tam, Nadya M. Morrow, Ilka Lorenzen‐Schmidt, Fengxia Xiao, Augusto Zani, Dylan Burger, Hye Kyoung Sung, Erin E. Mulvihill, Gary Sweeney   +13 more
wiley   +1 more source

Diastolic-Cardiac Dysfunction

Acta Médica del Centro, 2007
Heart failure is defined as a disorder of heart's inability to pump blood with normal efficiency for providing an adequate cardiac output in presence of a normal vein return.
Carlos Enrique Herrera Cartaya, Luis Alberto Santos Pérez   +1 more
doaj  

Changes in plasma levels of B-type natriuretic peptide with acute exacerbations of chronic obstructive pulmonary disease.

, 2014
Background: Elevated plasma B-type natriuretic peptide (BNP) levels and their association with heart failure have been reported in subjects with acute exacerbations of chronic obstructive pulmonary disease (AECOPD).
Oga, T, Nishimura, K, Nishimura, T, Onishi, K, Jones, PW, Hasegawa, Y   +5 more
core   +1 more source

Multiple common comorbidities produce left ventricular diastolic dysfunction associated with coronary microvascular dysfunction, oxidative stress, and myocardial stiffening

Cardiovascular Research, 2018
Aims More than 50% of patients with heart failure have preserved ejection fraction characterized by diastolic dysfunction. The prevalance of diastolic dysfunction is higher in females and associates with multiple comorbidities such as hypertension (HT ...
O. Sorop, I. Heinonen, Matthijs van Kranenburg, J. van de Wouw, Vincent J. de Beer, Isabel T N Nguyen, Y. Octavia, Richard W. B. van Duin, K. Stam, R. V. van Geuns, P. Wielopolski, G. Krestin, A. H. van den Meiracker, R. Verjans, M. van Bilsen, A. Danser, W. Paulus, Caroline Cheng, W. Linke, J. Joles, M. Verhaar, J. van der Velden, D. Merkus, D. Duncker   +23 more
semanticscholar   +1 more source

Canagliflozin Alleviates Diabetic Glomerular Endothelial Injury via Melibiose in a Microbiota‐Dependent Manner

Advanced Science, EarlyView.
Canagliflozin treatment reshapes the gut microbiota in DKD and elevates levels of melibiose, a metabolite derived from Roseburia intestinalis. Melibiose directly binds to and enhances the enzymatic activity of glyoxalase 1, leading to decreased methylglyoxal accumulation.
Wei Zhang, Yi Song, Changkun Li, Yuanyuan Luo, Mingwei Shao, Feng Guo, Fangyi Wei, Xunjie Fan, Wenwen Guo, Fengmei Xu, Yanhong Sang, Dongming Zhang, Yanhong Zhou, Lianwei Wang, Zhiqiang Kang, Yingjun Yang, Chunhua Song, Yanxia Liu, Xiaojun Ma, Jiao Wang, Chong Li, Shengnan Ma, Lin Zhao, Zhi Qin, Guolan Xing, Qiubo Zhao, Jun Li, Shumin Song, Dan Zhao, Ting Huang, Qingzhu Wang, Yanyan Zhao, Guijun Qin   +32 more
wiley   +1 more source

Circulating tissue inhibitor of matrix metalloproteinase-1 is associated with aldosterone-induced diastolic dysfunction

, 2017
Objective: To test if collagen markers are associated with aldosterone-induced diastolic dysfunction. Background: Although primary aldosteronism is associated with more prominent cardiac remodeling and diastolic dysfunction, the reversibility of ...
Hung, Chi-Sheng;Chou, Chia-Hung;Wu, Xue-Ming;Chang, Yi-Yao;Wu, Vin-Cent;Chen, Ying-Hsien;Chang, Yuan-Shian;Tsai, Yao-Chou;Su, Ming-Jai;Ho, Yi-Lwun;Chen, Ming-Fong;Wu, Kwan-Dun;Lin, Yen-Hung, 林彥宏;洪啟盛;陳明豐;吳允升;吳寬墩;陳盈憲;蘇銘嘉;何奕倫   +1 more
core   +1 more source

Managing Diastolic Dysfunction Perioperatively

Seminars in Cardiothoracic and Vascular Anesthesia, 2022
Preoperative cardiac evaluation is a cornerstone of the practice of anesthesiology. This consists of a thorough history and physical attempting to elucidate signs and symptoms of heart failure, angina or anginal equivalents, and valvular heart disease.
Theodore J. Cios, John C. Klick, S. Michael Roberts   +2 more
openaire   +2 more sources

G3BP1 Succinylation at K413 is Critical for Cardiac Function by Modulating PI3K‐AKT‐mTOR Signal Axis

Advanced Science, EarlyView.
Schematic illustrating the impact of G3BP1 succinylation at K413 on cardiac function. In the healthy human heart, G3BP1 succinylation maintains homeostatic mTOR signaling. In patients with dilated cardiomyopathy (DCM) and heart failure (HF), G3BP1 de‐succinylation induces RagA expression and disrupts the binding of the TSC1/2 complex, leading to the ...
Yuan Zhang, Cancan Yao, Yan Chen, Ke Cai, Zhouping Lu, Boxuan Wu, Kun Yu, Yan Shi, Jianyuan Zhao, Xiangyu Zhou   +9 more
wiley   +1 more source

Correlation between 2D Echocardiography and Multidetector Row CT for Early Detection of Diastolic Dysfunction in Normotensive Diabetic Patients [PDF]

Journal of Clinical and Diagnostic Research, 2016
Introduction: Abnormalities in diastolic function are considered early signs of diabetic cardiomyopathy. Two dimensional echocardiography with Tissue Doppler Imaging (TDI) has been used most commonly to evaluate diastolic left ventricular function ...
Vikas Agrawal, Arpit Agrawal, Amit Nandan Dwivedi, Kamalakar Tripathi   +3 more
doaj   +1 more source

Accumulation of epicardial fat rather than visceral fat is an independent risk factor for left ventricular diastolic dysfunction in patients undergoing peritoneal dialysis

, 2014
Background: Symptoms of heart failure with preserved left ventricular systolic function are common among patients undergoing peritoneal dialysis (PD).
Lin, Heng-Hsu;Lee, Jen-Kuang;Yang, Chung-Yi;Lien, Yu-Chung;Huang, Jenq-Wen;Wu, Cho-Kai, 吳卓鍇 ;楊中宜 ;黃政文   +1 more
core   +1 more source