Results 81 to 90 of about 1,526,915 (347)

Role of estrogen in diastolic dysfunction

American Journal of Physiology-Heart and Circulatory Physiology, 2014
The prevalence of left ventricular diastolic dysfunction (LVDD) sharply increases in women after menopause and may lead to heart failure. While evidence suggests that estrogens protect the premenopausal heart from hypertension and ventricular remodeling, the specific mechanisms involved remain elusive.
Zhuo, Zhao, Hao, Wang, Jewell A, Jessup, Sarah H, Lindsey, Mark C, Chappell, Leanne, Groban   +5 more
openaire   +3 more sources

Brown Adipocyte Sheets Alleviate Myocardial Ischemia–Reperfusion Injury Through NRG4–ErbB4–Dependent Ferroptosis Inhibition

Advanced Science, EarlyView.
Brown adipocyte sheets are engineered to protect the heart against myocardial ischemia–reperfusion injury by restraining ferroptosis. Upon transplantation onto the cardiac surface, they improve cardiac function, limit infarction and fibrosis, and enhance angiogenesis.
Lifu Sun, Yuting Liu, Jingbo Zhang, Takuji Kawamura, Junjun Li, Li Liu, Shigeru Miyagawa   +6 more
wiley   +1 more source

The prevalence of left ventricular diastolic dysfunction and heart failure with preserved ejection fraction in men and women with type 2 diabetes: A systematic review and meta-analysis

Diabetes & vascular disease research, 2018
Objective: Type 2 diabetes is a risk factor for the development of left ventricular diastolic dysfunction and heart failure with preserved ejection fraction.
Selma Bouthoorn, G. Valstar, A. Gohar, H. D. den Ruijter, Hans B. Reitsma, A. Hoes, F. Rutten   +6 more
semanticscholar   +1 more source

Senescent Cell Derived Artificial Vesicle‐Based Senolytic Sonovaccine Platform with Augmented Lymph Node Delivery and Antigen Cross‐Presentation Efficacy

Advanced Science, EarlyView.
A senolytic sonovaccine platform (SenoVac) is developed, in which senescent cell‐derived vesicles serve as broad senescent cell antigen reservior. The “2‐step” click chemistry strategy for effective lymph node delivery, and ultrasound‐triggered endosomal escape to boost cross‐presentation, ensures efficient senescent cell clearance and disease ...
Liang Zhang, Yubo Lai, Jia Wang, Lingling Liu, Jieyuan An, Mi Qu, Yuan Liang, Bijun Tan, Guodong Yang, Xuekang Yang, Lijun Yuan   +10 more
wiley   +1 more source

Arterial stiffening is a crucial factor for left ventricular diastolic dysfunction in a community-based normotensive population

International Journal of Cardiology. Hypertension, 2020
Background: Left ventricular (LV) diastolic dysfunction is an important underlying hemodynamic mechanism for heart failure. Hypertension reportedly increases aortic stiffness with histological changes in the aorta assessed using aortic pulse wave ...
Maeda Mika, Hideaki Kanzaki, Takuya Hasegawa, Hiroki Fukuda, Makoto Amaki, Jiyoong Kim, Masanori Asakura, Hiroshi Asanuma, Motonobu Nishimura, Masafumi Kitakaze   +9 more
doaj   +1 more source

Histone deacetylase activity governs diastolic dysfunction through a nongenomic mechanism

Science Translational Medicine, 2018
The histone deacetylase inhibitor ITF2357 (givinostat) prevents diastolic dysfunction by enhancing cardiac myofibril relaxation. Deacetylation and diastolic dysfunction Systolic heart failure (heart failure with reduced ejection fraction) manifests as ...
M. Jeong, Ying-Hsi Lin, Sara A. Wennersten, Kimberly M. Demos-Davies, M. Cavasin, Jennifer H. Mahaffey, V. Monzani, Chandra Saripalli, P. Mascagni, T. Reece, A. Ambardekar, H. Granzier, C. Dinarello, T. McKinsey   +13 more
semanticscholar   +1 more source

Leonurine Ameliorates Doxorubicin‐Induced Cardiotoxicity via STING/NF‐κB/NLRP3 Inflammasome Signaling Pathway

Advanced Science, EarlyView.
ABSTRACT Doxorubicin‐induced cardiomyopathy (DIC) remains a dose‐limiting clinical challenge. This study reveals that cardiac vascular endothelial cells (CVECs) act as initial sensors of doxorubicin cardiotoxicity: circulating doxorubicin activates the cGAS‑STING pathway in CVECs, triggering NLRP3 inflammasome‑mediated pyroptosis and release of ...
Wang Jun, Chen Xiaoyang, Xu Jianglin, Yang Zhi, Tao Meijiao, He Jiale, Zhao Jiangfeng, Hei Xuanding, Xu Xuegong, Wang Wei, Li Chun   +10 more
wiley   +1 more source

Liver cirrhosis and left ventricle diastolic dysfunction: Systematic review

World Journal of Gastroenterology, 2019
BACKGROUND Liver cirrhosis is a chronic hepatic disease which is associated with cardiovascular abnormalities. Hyperdynamic circulation in liver cirrhosis causes functional and structural cardiac alterations.
I. Stundienė, Julija Sarnelyte, Ausma Norkute, S. Aidietienė, V. Liakina, Laura Mašalaitė, J. Valantinas   +6 more
semanticscholar   +1 more source

Chronic Disease Monitoring Using Advanced Compliant Materials for Bioelectronics

Advanced Electronic Materials, EarlyView.
Compliant bioelectronic systems enable continuous monitoring of chronic disease through soft, stretchable materials and tissue‐conformal designs that support stable electrophysiological, mechanical, and biochemical sensing. Integration of diverse sensing modalities with thoughtful material selection, device architectures, and advanced fabrication ...
Han Kim, Mabel Bartlett, Liyang Wang, Karl Bates, Mengdi He, Myungbo Kim, Carmel Majidi, Tzahi Cohen‐Karni   +7 more
wiley   +1 more source

Left ventricular diastolic function and cardiotoxic chemotherapy

The Egyptian Heart Journal
Background Left ventricular ejection fraction falls when the myocardium has already lost a significant portion of its functional capacity. There are conflicting data on whether diastolic dysfunction precedes systolic dysfunction after cardiotoxic ...
Haider Rashid, Aamir Rashid, Asif Mattoo, Faisal R. Guru, Syed Mehvish, Shahood Ajaz Kakroo, Ajaz Ahmad Lone, Khursheed Aslam, Imran Hafeez, Hilal Rather   +9 more
doaj   +1 more source