Results 91 to 100 of about 144,206 (380)

The challenge of ultra‐rarity: Dual diagnosis of Lafora disease and developmental encephalopathies linked to TRIO and SHANK3 pathogenic variants

Epilepsia Open, EarlyView.
Abstract We report two cases of dual genetic diagnoses involving Lafora disease (LD) and co‐occurring neurodevelopmental disorders caused by pathogenic variants in TRIO and SHANK3, respectively. LD is an ultra‐rare, autosomal recessive, severe form of progressive myoclonus epilepsy affecting previously healthy children or adolescents. In both patients,
Lorenzo Muccioli, Francesca Bisulli, Raffaella Minardi, Maria Lucia Valentino, Micaela De Simone, Rodrigo Almeida Paroni, Edward Cesnik, Elisa Fallica, Luigi Bonan, Eleonora Pizzi, DEFEAT‐LD Study Group, Cosimo Altomare, Massimo Carella, Cinzia Costa, Giuseppe Damante, Lidia Di Vito, Giuseppe d’Orsi, Nicola Gambacorta, Paola Imbrici, Valentina Imperatore, Antonella Liantonio, Laura Licchetta, Raffaele Lodi, Paola Mantuano, Orazio Palumbo, Elena Pasini, Paolo Prontera, Luca Vignatelli, Gaetano Cantalupo, Laura Licchetta   +29 more
wiley   +1 more source

Diazepam exposure associated with an increased risk of acute kidney injury in children: an observational cohort study

BMC Pediatrics
Background Potentially nephrotoxic drugs play an important role in acute kidney injury (AKI) in children. In the previous pharmacovigilance study, we found a statistical correlation between diazepam and AKI in children, but the causality needs to be ...
Miao Zhang, Liang Huang, Yu Zhu, Linan Zeng, Guo Cheng, Hailong Li, Lingli Zhang   +6 more
doaj   +1 more source

Frontiers in EEG as a tool for the management of pediatric epilepsy: Past, present, and future

Epilepsia Open, EarlyView.
Abstract Electroencephalography (EEG) has evolved into an indispensable tool in pediatric epilepsy, fundamentally transforming the diagnosis, classification, and management of this condition. This review chronicles the historical journey of EEG from its groundbreaking inception to its current pivotal role in delineating distinct pediatric epilepsy ...
Hiroki Nariai
wiley   +1 more source

Inhibitory Effect of Imperatorin on the Pharmacokinetics of Diazepam In Vitro and In Vivo

Frontiers in Pharmacology, 2020
BackgroundDiazepam is a benzodiazepine drug used to treat anxiety, insomnia, and muscle spasms. Imperatorin is a phytochemical isolated from medicinal plants and is widely used in herbal medicine. The aim of this study was to investigate the interactions
Yunfang Zhou, Deru Meng, Deru Meng, Feifei Chen, Zhengping Wu, Binglan Wang, Shuanghu Wang, Peiwu Geng, Dapeng Dai, Quan Zhou, Weiwen Qiu, Weiwen Qiu, Weiwen Qiu   +12 more
doaj   +1 more source

The effects of diazepam on the elevated T-maze are dependent on the estrous cycle of rats [PDF]

, 2009
In order to determine the modulation of anxiolytic and panicolytic-like effects of diazepam by the hormonal cycle of female rats, male and female rats - the latter divided per estrous cycle phase (estrus, diestrus, metaestrus and proestrus) - were tested
ANTUNES, Gabriela, GOUVEIA JR, Amauri, MAXIMINO, Caio, MORATO, Silvio   +3 more
core   +1 more source

Rescue epilepsy medication and training: A comparison between midazolam use, guidelines, clinical practice, and possibilities in the UK and Norway

Epilepsia Open, EarlyView.
Abstract Objectives Status epilepticus (SE) is a prolonged epileptic seizure carrying significant risk of long‐term disability and death. Rescue therapies are prescribed for prehospital administration to terminate SE. This study compared prescribing practices of rescue therapies of midazolam in the UK and Norway.
Audrey McBride, Oliver Johannes Henning, Cecilie Johannessen Landmark, Lance Watkins, Samuel Tromans, Paul Basset, Paraskevi Triantafyllopoulou, Rohit Shankar   +7 more
wiley   +1 more source

Use of Diazepam to Correct Hemodynamic Changes in Explosive Mine Injury: Experimental Study

Общая реаниматология, 2007
Objective. To study the hemodynamic effect of benzodiazepine tranquilizers in explosive mine injury in an experiment.Materials and methods. The study was performed on non-inbred male rats; hemodynamic parameters were examined at the systemic, organ, and ...
V. N. Yelsky, G. K. Krivobok, Ye. V. Antonov   +2 more
doaj   +1 more source

Maxillary nerve block: A comparison between the greater palatine canal and high tuberosity approaches. [PDF]

, 2018
Aim: Analgesia and anxiolysis during dental procedures are important for dental care and patient compliance. This study aims to compare two classical maxillary nerve block (MNB) techniques: the greater palatine canal (GPC) and the high tuberosity (HT ...
Bacci, C, Bartorelli, Lmg, Ferrario, S, Grossi, Gb, Menozzi, G, Sivolella, S, Zanette, G.   +6 more
core  

Status epilepticus: Updates on mechanisms and treatments

Epilepsia Open, EarlyView.
Abstract Status epilepticus (SE) consists of prolonged, self‐sustaining seizures and is a common neurological emergency that causes respiratory compromise and neuronal injury. Without prompt treatment, the seizures can become resistant to benzodiazepines, leading to the progressive evolution of established, refractory, and super‐refractory SE.
Suchitra Joshi, Jaideep Kapur
wiley   +1 more source

The Emergence of Novel Benzodiazepines in Australia, Evidence, Alerts, Clinical Management and Harm Reduction-A Narrative Review. [PDF]

Drug Alcohol Rev
ABSTRACT Issues In Australia, detections of novel benzodiazepines (NBZ) and related overdoses have increased markedly over the last five years. This review summarises Australian peer‐reviewed literature and NBZ‐related drug alerts, outlines the pharmacology of commonly detected NBZs and discusses approaches to harm reduction, managing toxicity ...
Freestone J, Kypri S, Schumann JL, Franklin E, Francis C, Barratt MJ, Peacock A, Sutherland R, Clifford B, MacDonald H, Ezard N, Fletcher K, Acheson L, Siefried KJ.   +13 more
europepmc   +2 more sources