Results 141 to 150 of about 83,280 (287)

Diazepam-ketamine anaesthesia for open heart surgery a “micro-mini” drip administration technique [PDF]

, 1976
S Hatano, Donal M. Keane, Roy E. Boggs, Moustafa A. El-Naggar, Max S. Sadove   +4 more
openalex   +1 more source

ENX‐101, a GABAA receptor α2,3,5‐selective positive allosteric modulator, displays antiseizure effects in rodent seizure and epilepsy models

Epilepsia, EarlyView.
Abstract Objective γ‐Aminobutyric acid type A (GABAA) receptor positive allosteric modulators (PAMs) that lack α‐subunit selectivity, including benzodiazepines such as diazepam, exhibit antiseizure actions in animal models and in humans. ENX‐101 is a deuterated analog of the ⍺2,3,5‐selective GABAA receptor PAM L‐838,417.
Jordi Serrats, Krishna C. Vadodaria, William Brubaker, Melissa Barker‐Haliski, H. Steve White, Alexis Evrard, Corinne Roucard, Eve Taylor, Kimberly E. Vanover, Stephen Cunningham, Vikram Sudarsan, Michael A. Rogawski   +11 more
wiley   +1 more source

STUDIES OF DRUGS GIVEN BEFORE ANAESTHESIA XIV: TWO BENZODIAZEPINE DERIVATIVES—CHLORDIAZEPOXIDE AND DIAZEPAM

, 1968
W.H.K. HASLETT, J. W. Dundee
openalex   +1 more source

Profound hypothermia on combined lithium carbonate and diazepam treatment. [PDF]

, 1977
G. J. Naylor, A. M. McHarg
openalex   +1 more source

Medication‐resistant epilepsy is associated with a unique gut microbiota signature

Epilepsia, EarlyView.
Abstract Objective Dysfunction of the microbiota–gut–brain axis is emerging as a new pathogenic mechanism in epilepsy, potentially impacting on medication response and disease outcome. We investigated the composition of the gut microbiota in a cohort of medication‐resistant (MR) and medication‐sensitive (MS) pediatric patients with epilepsy.
Antonella Riva, Eray Sahin, Greta Volpedo, Noemi Teresa Catania, Isabel Venara, Valentina Biagioli, Ganna Balagura, Elisabetta Amadori, Carmen De Caro, Emanuele Cerulli Irelli, Carlo Di Bonaventura, Federico Zara, Osman Ugur Sezerman, Emilio Russo, Pasquale Striano   +14 more
wiley   +1 more source

Long‐term seizure and psychosocial outcomes of patients with ring chromosome 20 syndrome: A cohort study of 47 cases

Epilepsia, EarlyView.
Abstract Objective We retrospectively investigated a cohort of patients with ring chromosome 20 syndrome (r20), aiming to provide information on the prognosis of r20 regarding seizures, cognitive function, comorbidities, and social living. Methods Patients diagnosed with r20 in our hospital were identified, and clinical data were extracted from medical
Kentaro Tokumoto, Takuji Nishida, Hitoshi Ikeda, Hiroko Ikeda, Norihiko Kawaguchi, Satoshi Mizutani, Tokito Yamaguchi, Hideyuki Ohtani, Etsuko Yamazaki, Naotaka Usui, Katsumi Imai, Yushi Inoue   +11 more
wiley   +1 more source

Quantitative Determination of Medazepam, Diazepam, and Nitrazepam in Whole Blood by Flame-Ionization Gas—liquid Chromatography [PDF]

, 1974
M Greaves
openalex   +1 more source

EEG signal dimension is an index of seizure propensity and antiseizure medication effects in a mouse model of acquired epilepsy

Epilepsia, EarlyView.
Abstract Objective Variability in the frequency, timing, and pattern of seizures may influence the assessment of the effect of antiseizure medications (ASMs) when measuring seizure frequency, especially in patients with infrequent seizures. A low seizure rate is an exclusion criterion for enrollment of patients with epilepsy in clinical trials and ...
Massimo Rizzi, Peter J. West, Annamaria Vezzani, Karen S. Wilcox, Alessandro Giuliani   +4 more
wiley   +1 more source

Synaptic inhibitory dynamics drive benzodiazepine response in pediatric status epilepticus

Epilepsia, EarlyView.
Abstract Objective Pediatric status epilepticus (SE) is a medical emergency associated with significant morbidity. Benzodiazepines (BZPs) are the current first‐line treatment, but do not work in more than one third of children presenting with SE. Animal studies have shown that SE can cause changes in synaptic inhibition signaling that can ultimately ...
Tommaso Fedele, Richard J. Burman, Anne Steinberg, Giorgio Selmin, Georgia Ramantani, Richard E. Rosch   +5 more
wiley   +1 more source

Strain-dependent effects of diazepam and the 5-HT2B/2C receptor antagonist SB 206553 in spontaneously hypertensive and Lewis rats tested in the elevated plus-maze

Brazilian Journal of Medical and Biological Research, 2001
The 5-HT2B/2C receptor antagonist SB 206553 exerts anxiolytic effects in rat models of anxiety. However, these effects have been reported for standard rat strains, thus raising the issue of SB 206553 effects in rat strains displaying different levels of ...
Takahashi R.N., Berton O., Mormède P., Chaouloff F.   +3 more
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