Results 141 to 150 of about 109,445 (330)

Bosutinib mitigates inflammation in experimental sepsis

open access: yesEuropean Journal of Clinical Investigation, EarlyView.
Abstract Background Sepsis, a leading cause of death globally, lacks targeted and effective treatment. Its pathophysiology involves unbalanced inflammation, marked by a high release of inflammatory mediators, leukocyte recruitment, vascular changes and dysfunction of the nervous and respiratory systems. Src family tyrosine kinases (SFK) play a critical
C. M. C. Cunha   +14 more
wiley   +1 more source

Community‐onset pediatric status epilepticus: Barriers to care and outcomes in a real‐world setting

open access: yesEpilepsia, Volume 66, Issue 3, Page 725-738, March 2025.
Abstract Objective Status epilepticus (SE) is a neurological emergency in childhood, often leading to neuronal damage and long‐term outcomes. The study aims to identify barriers in the pre‐hospital and in‐hospital management of community‐onset pediatric SE and to evaluate the effectiveness of pediatric scores on outcomes prediction.
Anna Fetta   +12 more
wiley   +1 more source

Application of the Sensory Contact Model for Pharmacological Studies under Simulated Clinical Conditions [PDF]

open access: yes, 2007
The sensory contact model allows forming different psycho-pathological states (anxious depression, catalepsy, social withdrawal, pathological aggression, cognition disturbances, anhedonia, addictive states etc.) produced by repeated agonistic ...
Damira F. Avgustinovich   +4 more
core   +1 more source

Prognostic factors and impact of management strategies for status epilepticus: The STEPPER study in the Emilia‐Romagna region, Italy

open access: yesEpilepsia, Volume 66, Issue 3, Page 753-767, March 2025.
Abstract Objective The STEPPER (Status Epilepticus in Emilia‐Romagna) study aimed to investigate the clinical characteristics, prognostic factors, and treatment approaches of status epilepticus (SE) in adults of the Emilia‐Romagna region (ERR), Northern Italy.
Lidia Di Vito   +56 more
wiley   +1 more source

Medication‐resistant epilepsy is associated with a unique gut microbiota signature

open access: yesEpilepsia, EarlyView.
Abstract Objective Dysfunction of the microbiota–gut–brain axis is emerging as a new pathogenic mechanism in epilepsy, potentially impacting on medication response and disease outcome. We investigated the composition of the gut microbiota in a cohort of medication‐resistant (MR) and medication‐sensitive (MS) pediatric patients with epilepsy.
Antonella Riva   +14 more
wiley   +1 more source

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