Results 141 to 150 of about 100,045 (277)

Strain-dependent effects of diazepam and the 5-HT2B/2C receptor antagonist SB 206553 in spontaneously hypertensive and Lewis rats tested in the elevated plus-maze

Brazilian Journal of Medical and Biological Research, 2001
The 5-HT2B/2C receptor antagonist SB 206553 exerts anxiolytic effects in rat models of anxiety. However, these effects have been reported for standard rat strains, thus raising the issue of SB 206553 effects in rat strains displaying different levels of ...
Takahashi R.N., Berton O., Mormède P., Chaouloff F.   +3 more
doaj  

Reconstruction of an orbital fracture in a mare using a 3D‐printed patient‐specific implant

Veterinary Surgery, EarlyView.
Abstract Objective To describe surgical repair of an orbital wall fracture communicating with the caudal maxillary sinus using a three dimensional (3D)‐printed, patient‐specific implant (PSI). Study design Case report. Animal A 25‐year‐old Haflinger mare (370 kg). Methods The mare presented with severe chemosis and emphysema of the left upper and lower
Jennifer Gernhardt, Peter Böttcher, J. Corinna Eule, Kathrin Mählmann, Eva Müller, Christoph J. Lischer   +5 more
wiley   +1 more source

The effect of arthroscopic lavage volume on bacterial culture of egress fluid in horses with experimentally induced septic arthritis and synovitis

Veterinary Surgery, EarlyView.
Abstract Objective To evaluate if high‐volume lavage results in a negative bacterial culture of egress fluid, regardless of pathogen in an experimental model of equine septic arthritis. Study design Experimental study. Animals A total of 11 horses in three groups (lipopolysaccharide [LPS] Group 1, n = 4; Escherichia coli [E.
Alannah M. Friedlund, Jose L. Bracamonte, Roman V. Koziy, Tasha Epp, Keri L. Thomas   +4 more
wiley   +1 more source

α‐Adrenergic blockade impairs ductus venosus shunting during an acute period of fetal hypoxaemia without further deficits to cerebral oxygen delivery

Experimental Physiology, EarlyView.
Abstract The fetal circulation has unique shunts, including the ductus venosus (DV), the tone of which dictates how much substrate‐rich blood returning from the placenta is streamed preferentially away from the liver and instead towards the heart. Herein, we aimed to use clinically relevant MRI techniques in sheep to measure indirectly induced changes ...
Jack R. T. Darby, Stacey L. Holman, Brahmdeep S. Saini, Sunthara Rajan Perumal, Mike Seed, Christopher K. Macgowan, Janna L. Morrison   +6 more
wiley   +1 more source

Methodological comparison of fetal brain 1H‐MRS data analysis techniques and gestational age analysis using LCModel in the fetal sheep brain

Experimental Physiology, EarlyView.
Abstract Proton (1H) magnetic resonance spectroscopy (MRS) is a non‐invasive imaging technique that can be used to assess brain metabolism. Establishing reference levels of fetal brain metabolites in a translatable preclinical model is crucial for identifying subtle deviations from normal cerebral development. Herein, we developed a 1H‐MRS protocol for
Jordan A. Minns, Jack R. T. Darby, Georgia K. Williams, Jesse T. Tu, Ziqi Sun, Jessie Guo, Steven P. Miller, Christopher K. Macgowan, Mike Seed, Jamie Near, Janna L. Morrison   +10 more
wiley   +1 more source

Unveiling protective mechanisms of wild olive (acebuche) oil in retinal pigment epithelial cells with hypertensive phenotype

The Journal of Physiology, EarlyView.
Abstract figure legend Circulating extracellular vesicles (EVs) derived from acebuche (ACE) oil‐ and extra virgin olive oil (EVOO)‐fed mice modulate nitric oxide (NO) metabolism in the retinal pigment epithelial cell line (ARPE19) with a hypertensive phenotype induced by angiotensin II (AngII).
Álvaro Santana‐Garrido, Claudia Reyes‐Goya, Pablo Espinosa‐Martín, Rosa M. Troya‐Toledo, Helder André, Alfonso Mate, Carmen M. Vázquez   +6 more
wiley   +1 more source

Intranasal Diazepam Outperforms Midazolam and Lorazepam in Early Seizure Control in Pilocarpine-Induced Mice Model. [PDF]

Neurochem Res
Tong AH, Zhao J, Li J, Ban W, Wang RJ, Xie Y, Zhang Y, Zuo Z.   +7 more
europepmc   +1 more source

Fetal glucose availability: a key regulator of the metabolic, hormonal and contractility profiles of the fetal sheep heart

The Journal of Physiology, EarlyView.
Abstract figure legend To investigate the role of glucose availability in fetal left ventricle (LV) development, this study assessed whether maternal late gestation undernutrition (LGUN; 50% of Control diet) induced alterations in the contractility, metabolic, and hormonal profile can be ameliorated in LGUN fetuses receiving glucose infusion (LGUN+G ...
Melanie R. Bertossa, Jack R. T. Darby, Stacey L. Holman, Steven K. S. Cho, Ashley S. Meakin, Mitchell C. Lock, Jordan A. Minns, Michael D. Wiese, Christopher K. Macgowan, Mike Seed, Janna L. Morrison   +10 more
wiley   +1 more source

Diazepam

Environmental Health Perspectives, 1997
openaire   +3 more sources

Development and Validation of an HPLC-MS/MS Method for Pharmacokinetic Evaluation of Tofacitinib/Simvastatin Compound Ointment in Rats. [PDF]

Drug Des Devel Ther
Wang S, Zhang C, Li J, Li G, Qi Y.
europepmc   +1 more source