Results 151 to 160 of about 109,445 (330)
Background and aims: Valeriana officinalis is one of the most practical herbal medicines with anxiolytic and sedative properties. This study was conducted to compare herbal medicine V.
Golamreza Shabanian+4 more
doaj
Psychomotor Skills Related to Driving after Intramuscular Administration of Diazepam and Meperidine [PDF]
K. Korttila, Markku Linnoila
openalex +1 more source
Abstract Objective We retrospectively investigated a cohort of patients with ring chromosome 20 syndrome (r20), aiming to provide information on the prognosis of r20 regarding seizures, cognitive function, comorbidities, and social living. Methods Patients diagnosed with r20 in our hospital were identified, and clinical data were extracted from medical
Kentaro Tokumoto+11 more
wiley +1 more source
Abstract Objective Variability in the frequency, timing, and pattern of seizures may influence the assessment of the effect of antiseizure medications (ASMs) when measuring seizure frequency, especially in patients with infrequent seizures. A low seizure rate is an exclusion criterion for enrollment of patients with epilepsy in clinical trials and ...
Massimo Rizzi+4 more
wiley +1 more source
Synaptic inhibitory dynamics drive benzodiazepine response in pediatric status epilepticus
Abstract Objective Pediatric status epilepticus (SE) is a medical emergency associated with significant morbidity. Benzodiazepines (BZPs) are the current first‐line treatment, but do not work in more than one third of children presenting with SE. Animal studies have shown that SE can cause changes in synaptic inhibition signaling that can ultimately ...
Tommaso Fedele+5 more
wiley +1 more source
Abstract Clinical development of novel antiseizure medications (ASMs) would benefit from an early proof of principle (POP) model. The photosensitivity model, which uses the photoparoxysmal electroencephalographic response (PPR) as a surrogate of seizures, is currently the only human model that allows POP trials of investigational compounds after a ...
Wolfgang Löscher+1 more
wiley +1 more source
Status epilepticus in older adults: A critical review
Abstract Older adults (≥60 years of age) have the highest incidence of status epilepticus (SE) among adults and experience the highest morbidity and mortality. SE incidence increases with age in adulthood. A recent study from Austria estimated an incidence of 89.6/100 000 and 67.6/100 000 person‐years adjusted for age and sex in women and men aged >60 ...
Matthew R. Woodward+5 more
wiley +1 more source
The 5-HT2B/2C receptor antagonist SB 206553 exerts anxiolytic effects in rat models of anxiety. However, these effects have been reported for standard rat strains, thus raising the issue of SB 206553 effects in rat strains displaying different levels of ...
Takahashi R.N.+3 more
doaj