Results 151 to 160 of about 100,045 (277)

Electromechanical modelling and simulation of human‐induced pluripotent stem cell‐derived cardiomyocytes predict drug‐induced contractility effects

The Journal of Physiology, EarlyView.
Abstract figure legend A study described in this paper describes a new tool for hiPSC‐CM electromechanical behaviour simulations using mathematical modelling. The model enables in silico assays making drug testing quick, comprehensive and accurate. New hiPSC‐CM models can be used as a platform to integrate in vitro and in silico findings.
Milda Folkmanaite, Xin Zhou, Andreas Koschinski, Wan‐Hua Hong, Marilù Casini, Manuel Koch, Ursula Ravens, Remi Peyronnet, Manuela Zaccolo, Blanca Rodriguez   +9 more
wiley   +1 more source

Enhanced GABAergic actions resulting from the coapplication of the steroid 3α-hydroxy-5α-pregnane-11,20-dione (alfaxalone) with propofol or diazepam [PDF]

, 2018
Akk, Gustav, Cao, Lily Q, Chakrabarti, Shampuma, Evers, Alex S, Germann, Allison L, Mennerick, Steven, Montana, Michael C, Shin, Daniel J, Wozniak, David F, Yuede, Carla M   +9 more
core   +1 more source

Diazepam modulates anterior cingulate glutamate levels in people at clinical high-risk for psychosis. [PDF]

Int J Neuropsychopharmacol
Kiemes A, Livingston NR, Lukow PB, Knight S, Jelen L, Reilly T, Dima A, Nettis MA, Lythgoe DJ, Casetta C, Egerton A, Spencer T, De Micheli A, Fusar-Poli P, Grace AA, Williams SCR, McGuire P, Davies C, Stone JM, Modinos G.   +19 more
europepmc   +1 more source

Investigation of the actual implementation of “post‐sedation discharge criteria” and “time‐out” immediately before procedure in endoscopy: A nationwide survey study in Japan

DEN Open, Volume 6, Issue 1, April 2026.
ABSTRACT Objectives Post‐sedation discharge criteria for outpatient endoscopy and time‐out procedures immediately before endoscopic examinations are important for ensuring patient safety. This study used a web‐based questionnaire to survey the implementation status and current situation of these practices in Japan in 2024.
Atsushi Imagawa, Motohiko Kato, Junko Koyama, Mitsuhiro Fujishiro   +3 more
wiley   +1 more source

Severe anaphylaxis following off-label rectal use of injectable diazepam in a febrile seizure: a case report and clinical implications. [PDF]

Int J Emerg Med
Nguyen NX, Pham NT, Le HTT, Tran QV, Tran HNT, Vo TKT, Dang CTN.   +6 more
europepmc   +1 more source

Prevention of Cholangitis by Spontaneously Dislodging Biliary Stent After an Endoscopic Procedure in Patients With Asymptomatic Bile Duct Stones

DEN Open, Volume 6, Issue 1, April 2026.
ABSTRACT Objective To evaluate the effectiveness of spontaneously dislodging biliary stent (SDBS) placement in preventing acute cholangitis after endoscopic retrograde cholangiopancreatography (ERCP) in patients with asymptomatic bile duct stones. Methods This retrospective, single‐center study included 63 patients (mean age, 73 ± 11 years; 43 men) who
Shinichi Nihei, Sho Hasegawa, Yu Honda, Yuma Yamazaki, Takeshi Iizuka, Yusuke Kurita, Kunihiro Hosono, Masato Yoneda, Kensuke Kubota, Atsushi Nakajima   +9 more
wiley   +1 more source

Analysis of Illicit Street Heroin Seized in Pakistan by Gas Chromatography-Mass Spectrometry (GC-MS) for Identification of Adulterants and Impurities. [PDF]

Int J Anal Chem
Usman M, Baig Y, Naseer A, Nardiello D, Quinto M.   +4 more
europepmc   +1 more source

Zolpidem restores sleep and decreases amyloid in a mouse model

Alzheimer's &Dementia, Volume 22, Issue 3, March 2026.
Abstract INTRODUCTION Deficits in non–rapid eye movement (NREM) sleep facilitate Alzheimer's disease (AD) progression. Enhancing gamma‐aminobutyric acid‐ergic (GABAergic) signaling can restore sleep. Unbiased computational analysis identified zolpidem as high‐affinity GABA receptor modulator facilitating chloride transport that could slow AD.
Lu Yu, Shinya Yokomizo, Tri H. Doan, Qiuchen Zhao, Akshatha Ganne, Meenakshisundaram Balasubramaniam, Ksenia V. Kastanenka   +6 more
wiley   +1 more source

Recommendations for the community-based management of prolonged convulsive seizures in children in Europe. [PDF]

BMC Pediatr
Vigevano F, Arzimanoglou A, Auvin S, Kaindl AM, Lynch B, Mazurkiewicz-Bełdzińska M, Pujar S, Smeyers P, Cross JH.   +8 more
europepmc   +1 more source

Psychoactive prescription drug use and misuse in patients on opioid agonist treatment

British Journal of Clinical Pharmacology, Volume 92, Issue 3, Page 869-878, March 2026.
Aims To identify the patterns and trends in prescription drug use and misuse in patients on opioid agonist treatment. Methods We used data from the OPPIDUM programme, which collects data from patients attending substance abuse treatment facilities. Data collected include use of psychoactive prescription drugs in the past week.
Thomas Soeiro, Clémence Lacroix, Élisabeth Jouve, Élisabeth Frauger, Maryse Lapeyre‐Mestre, Joëlle Micallef   +5 more
wiley   +1 more source