Results 181 to 190 of about 86,598 (299)

Beyond the Michaelis–Menten: Evaluation of a tQSSA‐Based IVIVE Approach for Predicting In Vivo Intrinsic Clearance From Hepatocyte Assays

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 2, February 2026.
ABSTRACT The classical Michaelis–Menten model, under the standard quasi‐steady‐state approximation (sQSSA), is widely used in in vitro‐in vivo extrapolation (IVIVE) studies using hepatocyte or human liver microsomal (HLM) assays to predict intrinsic hepatic clearance (Clint,vitro$$ {\mathrm{Cl}}_{\operatorname{int},\mathrm{vitro}} $$).
Ngoc‐Anh Thi Vu, Yun Min Song, Sang Kyum Kim, Hwi‐yeol Yun, Soyoung Lee, Jae Kyoung Kim, Jung‐woo Chae   +6 more
wiley   +1 more source

Síndrome de la persona rígida

Revista Cubana de Medicina
RESUMEN El síndrome de la persona rígida es un trastorno neurológico infrecuente y desconcertante, caracterizado por contractura progresiva, rigidez y espasmos dolorosos que afectan la musculatura axial, lo que imposibilita la deambulación del paciente ...
Nelson Gómez Viera, Irma Regla Olivera Leal, Armando Pardo Núñez, Alexis Martínez Valdés   +3 more
doaj  

Reply: Comparative Dose-Response of Diazepam, Lorazepam, and Phenobarbital for Alcohol Withdrawal in the Emergency Department. [PDF]

Ann Pharmacother
Lebin JA, Goldberg EM, Hawk KF, Burnham EL, Hoppe JA.   +4 more
europepmc   +1 more source

Romifidine, diazepam and ketamin for sedation and anesthesia in colic-horses

, 1999
J Ohnesorge, K Otto, E Deegen
openalex   +2 more sources

Presentation, diagnosis and treatment of a prostatic abscess in an adult, male, neutered cat

Veterinary Record Case Reports, Volume 14, Issue 1, February 2026.
Abstract A 6‐year‐old, male, neutered Maine Coon cat presented with a 1‐week history of hyporexia, stranguria, pollakiuria and dysuria. Investigations, including abdominal ultrasound, positive contrast retrograde urethrocystogram and cytology of the prostate, were most consistent with a prostatic abscess.
Lydia Bloomfield, Natasha May, Andrea Holmes, Anna Frykfors von Hekkel   +3 more
wiley   +1 more source

Construction and Comparison of UPLC-QE-Orbitrap-MS and UPLC-MS/MS Methods for the Detection of Diazepam Residues in Complex Aquatic Matrices. [PDF]

Foods
Yang Y, Li Y, Tian Q, Yang J, Xu Y, Su W, Wang F, Qu S, Wen S, Cao W.   +9 more
europepmc   +1 more source

Intranasal and rectal diazepam for rescue therapy: assessment of pharmacokinetics and tolerability.

, 2010
Vijay Ivaturi
openalex   +1 more source

Effects of diazepam on hippocampal blood flow in people at clinical high risk for psychosis [PDF]

Nicholas R Livingston, Amanda Kiemes, Gabriel A. Devenyi, Samuel Knight, Paulina B. Lukow, Luke A. Jelen, Thomas J. Reilly, Aikaterini Dima, Maria Antonietta Nettis, Cecilia Casetta, Tyler Agyekum, Fernando Zelaya, Thomas Spencer, Andrea De Micheli, Paolo Fusar‐Poli, Anthony A. Grace, Steven Williams, Philip McGuire, Alice Egerton, M. Mallar Chakravarty, Gemma Modinos   +20 more
openalex   +1 more source

Acyl‐CoA Binding Protein in White and Brown Adipose Tissue Is Dispensable for Systemic Energy Metabolism in Mice

Acta Physiologica, Volume 242, Issue 2, February 2026.
ABSTRACT Aim Acyl‐CoA binding protein plays a vital role in lipid metabolism by mediating the intracellular flux and utilization of long‐chain acyl‐CoAs. We generated an adipocyte‐wide ACBP knockout mouse and a brown adipose tissue‐specific ACBP knockout mouse to investigate ACBP function in adipose tissue.
M. F. Nørremark, R. Petersen, P. M. M. Ruppert, E. S. Jul, T. K. Doktor, R. Nielsen, J. F. Kappel, S. Larsen, J. W. Kornfeld, S. Mandrup, B. S. Andresen, J. Havelund, D. Neess, N. J. Færgeman   +13 more
wiley   +1 more source

Development and Validation of an HPLC-MS/MS Method for Determining I-BET151 in Rat Plasma and Its application to Pharmacokinetic Studies. [PDF]

Drug Des Devel Ther
Wang S.
europepmc   +1 more source