Results 11 to 20 of about 86,598 (299)

Diazepam causes sedative rather than anxiolytic effects in C57BL/6J mice

Scientific Reports, 2021
Diazepam has been broadly accepted as an anxiolytic drug and is often used as a positive control in behavioral experiments with mice. However, as opposed to this general assumption, the effect of diazepam on mouse behavior can be considered rather ...
Marina Pádua-Reis, Diana Aline Nôga, Adriano B. L. Tort, Martina Blunder   +3 more
doaj   +2 more sources

Overcoming the challenges of developing an intranasal diazepam rescue therapy for the treatment of seizure clusters

Epilepsia, 2021
Seizure clusters must be treated quickly and effectively to prevent progression to prolonged seizures and status epilepticus. Rescue therapy for seizure clusters has focused on the use of benzodiazepines.
J. Cloyd, S. Haut, E. Carrazana, A. Rabinowicz   +3 more
semanticscholar   +1 more source

Pharmacokinetics and safety of VALTOCO (NRL‐1; diazepam nasal spray) in patients with epilepsy during seizure (ictal/peri‐ictal) and nonseizure (interictal) conditions: A phase 1, open‐label study

Epilepsia, 2020
To assess pharmacokinetics and safety of diazepam nasal spray (NRL‐1; VALTOCO®) in pediatric and adult patients with epilepsy in seizure and nonseizure states.
R. Hogan, D. Tarquinio, M. Sperling, P. Klein, I. Miller, E. Segal, A. Rabinowicz, E. Carrazana   +7 more
semanticscholar   +1 more source

A Short Review on the Intranasal Delivery of Diazepam for Treating Acute Repetitive Seizures

Pharmaceutics, 2020
Benzodiazepines such as diazepam, lorazepam and midazolam remained the mainstay of treatment for acute repetitive seizures (ARS). The immediate care for ARS should often begin at home by a caregiver.
S. Boddu, Sneha Kumari
semanticscholar   +1 more source

BERAPA KEBUTUHAN DIAZEPAM UNTUK MEMENUHI PELAYANAN KESEHATAN DI INDONESIA? STUDI KASUS KONSUMSI DIAZEPAM DI INDONESIA

Jurnal Manajemen dan Pelayanan Farmasi, 2016
Diazepam adalah obat esensial golongan benzodiazepin yang penggunaannya diawasi secara nasional dan global, oleh karena itu  ketersediaan untuk pelayanan kesehatan harus dapat terpenuhi.
Nunung Priyatni W
doaj   +1 more source

Perbandingan Efektivitas Pengobatan Lorazepam Bukal Dengan Diazepam Rektal dalam Tata Laksana awal Kejang pada Anak

Sari Pediatri, 2007
Latar belakang. Lorazepam bukal dan diazepam rektal digunakan dalam tata laksana inisial kejang pada anak. Penelitian yang membandingkan efektivitas penggunaan lorazepam bukal dan diazepam rektal sejauh ini belum pernah dilakukan pada anak di Indonesia ...
Susiana Tendean, Hardiono D. Pusponegoro, Bambang Madiyono   +2 more
doaj   +1 more source

Effects of Diazepam on Hematological and Histological Parameters in Rats / in Vivo and Unbiased Stereological Investigation

Acta Veterinaria, 2022
Diazepam-based drugs are widely used today in human treatment. Diazepam may be a primary drug aimed at treating neurological diseases or an associated drug in the treatment of other diseases in the purpose of symptomatic therapy.
Grahovac Jovana, Ivanković Milenka, Dekić Radoslav, Paraš Smiljana   +3 more
doaj   +1 more source

Case Report: Enhanced Diazepam Elimination With the Molecular Adsorbents Recirculating System (MARS) in Severe Autointoxication: A Survival Case Report

Frontiers in Medicine, 2021
Objective: Due to the extensive use of diazepam worldwide, self-induced intoxication is very common, yet rarely fatal. Nevertheless, the management of intoxication caused by extremely high doses of diazepam is not known, as well as the effectiveness of ...
Anna Dobisova, Peter Vavrinec, Diana Vavrincova-Yaghi, Andrea Gebhardtova, Robert H. Henning, Aktham Yaghi   +5 more
doaj   +1 more source

Constant rate infusion of diazepam or propofol for the management of canine cluster seizures or status epilepticus

Frontiers in Veterinary Science, 2022
IntroductionCluster seizures (CS) and status epilepticus (SE) in dogs are severe neurological emergencies that require immediate treatment. Practical guidelines call for constant rate infusion (CRI) of benzodiazepines or propofol (PPF) in patients with ...
Giulia Cagnotti, Sara Ferrini, Giorgia Di Muro, Giuliano Borriello, Cristiano Corona, Luca Manassero, Eleonora Avilii, Claudio Bellino, Antonio D'Angelo   +8 more
doaj   +1 more source

Polymeric nanoparticles containing diazepam: preparation, optimization, characterization, in-vitro drug release and release kinetic study

Nano Convergence, 2016
Nanoparticles formulated from biodegradable polymers like poly(lactic-co-glycolic acid) (PLGA) are being extensively investigated as drug delivery systems due to their two important properties such as biocompatibility and controlled drug release ...
S. Bohrey, V. Chourasiya, A. Pandey
semanticscholar   +1 more source