Results 11 to 20 of about 83,280 (287)

Infantile epileptic spasms syndrome in children with cardiofaciocutanous syndrome: Clinical presentation and associations with genotype

American Journal of Medical Genetics Part C: Seminars in Medical Genetics, Volume 190, Issue 4, Page 501-509, December 2022., 2022
Abstract Gene variants that dysregulate signaling through the RAS‐MAPK pathway cause cardiofaciocutaneous syndrome (CFCS), a rare multi‐system disorder. Infantile epileptic spasms syndrome (IESS) and other forms of epilepsy are among the most serious complications.
Daniel L. Kenney‐Jung, Dante J. Rogers, Samuel J. Kroening, Abigail L. Zatkalik, Ashley E. Whitmarsh, Amy E. Roberts, Martin Zenker, Maria Luigia Gambardella, Ilaria Contaldo, Chiara Leoni, Roberta Onesimo, Giuseppe Zampino, Marco Tartaglia, Domenica I. Battaglia, Elizabeth I. Pierpont   +14 more
wiley   +1 more source

Synergistic effects of applying static magnetic fields and diazepam to improve EEG abnormalities in the pilocarpine epilepsy rat model

Scientific Reports, 2023
The lithium-pilocarpine rat model is a well-known model of temporal epilepsy. Recently we found that transcranial static magnetic stimulation (tSMS) delay and reduce the signs of EEG in this model.
Carmen de Labra, Javier Cudeiro, Casto Rivadulla   +2 more
doaj   +1 more source

Bioavailability and safety of diazepam intranasal solution compared to oral and rectal diazepam in healthy volunteers

Epilepsia, 2020
The study assesses the bioavailability of diazepam after intranasal administration (diazepam nasal spray) in healthy volunteers. Comparative agents were diazepam rectal gel, which served as the regulatory reference product; and oral diazepam, a product ...
R. Hogan, B. Gidal, B. Koplowitz, L. P. Koplowitz, R. Lowenthal, E. Carrazana   +5 more
semanticscholar   +1 more source

Pharmacokinetics and safety of VALTOCO (NRL‐1; diazepam nasal spray) in patients with epilepsy during seizure (ictal/peri‐ictal) and nonseizure (interictal) conditions: A phase 1, open‐label study

Epilepsia, 2020
To assess pharmacokinetics and safety of diazepam nasal spray (NRL‐1; VALTOCO®) in pediatric and adult patients with epilepsy in seizure and nonseizure states.
R. Hogan, D. Tarquinio, M. Sperling, P. Klein, I. Miller, E. Segal, A. Rabinowicz, E. Carrazana   +7 more
semanticscholar   +1 more source

Effects of Diazepam on Hematological and Histological Parameters in Rats / in Vivo and Unbiased Stereological Investigation

Acta Veterinaria, 2022
Diazepam-based drugs are widely used today in human treatment. Diazepam may be a primary drug aimed at treating neurological diseases or an associated drug in the treatment of other diseases in the purpose of symptomatic therapy.
Grahovac Jovana, Ivanković Milenka, Dekić Radoslav, Paraš Smiljana   +3 more
doaj   +1 more source

BERAPA KEBUTUHAN DIAZEPAM UNTUK MEMENUHI PELAYANAN KESEHATAN DI INDONESIA? STUDI KASUS KONSUMSI DIAZEPAM DI INDONESIA

Jurnal Manajemen dan Pelayanan Farmasi, 2016
Diazepam adalah obat esensial golongan benzodiazepin yang penggunaannya diawasi secara nasional dan global, oleh karena itu  ketersediaan untuk pelayanan kesehatan harus dapat terpenuhi.
Nunung Priyatni W
doaj   +1 more source

Punica granatum peel supplementation attenuates cognitive deficits and brain injury in rat by targeting the Nrf2‐HO‐1 pathway

Food Science &Nutrition, Volume 11, Issue 1, Page 168-180, January 2023., 2023
The hydro‐ethanolic extract of P. granatum peel was standardized. ;The extract increased superoxide dismutase activity and thiol content, while reduced function of AchE and peroxidation of lipid in the scopolamine‐injured rat’s brain. ;P. granatum may attenuate scopolamine injury through targeting nuclear factor‐E2‐related factor 2 pathway ; Abstract ...
Mahsan Akbarian, Mahmoud Hosseini, Farshad Mirzavi, Sabiheh Amirahmadi, Fahimeh Lavi Arab, Arezoo Rajabian   +5 more
wiley   +1 more source

Perbandingan Efektivitas Pengobatan Lorazepam Bukal Dengan Diazepam Rektal dalam Tata Laksana awal Kejang pada Anak

Sari Pediatri, 2007
Latar belakang. Lorazepam bukal dan diazepam rektal digunakan dalam tata laksana inisial kejang pada anak. Penelitian yang membandingkan efektivitas penggunaan lorazepam bukal dan diazepam rektal sejauh ini belum pernah dilakukan pada anak di Indonesia ...
Susiana Tendean, Hardiono D. Pusponegoro, Bambang Madiyono   +2 more
doaj   +1 more source

Polymeric nanoparticles containing diazepam: preparation, optimization, characterization, in-vitro drug release and release kinetic study

Nano Convergence, 2016
Nanoparticles formulated from biodegradable polymers like poly(lactic-co-glycolic acid) (PLGA) are being extensively investigated as drug delivery systems due to their two important properties such as biocompatibility and controlled drug release ...
S. Bohrey, V. Chourasiya, A. Pandey
semanticscholar   +1 more source

Diazepam actions in the VTA enhance social dominance and mitochondrial function in the nucleus accumbens by activation of dopamine D1 receptors

Molecular Psychiatry, 2017
Benzodiazepines can ameliorate social disturbances and increase social competition, particularly in high-anxious individuals. However, the neural circuits and mechanisms underlying benzodiazepines’ effects in social competition are not understood ...
M. V. D. Kooij, F. Hollis, L. Lozano, I. Zalachoras, S. Abad, O. Zanoletti, J. Grosse, I. G. D. Suduiraut, C. Cantó, C. Sandi   +9 more
semanticscholar   +1 more source