Results 41 to 50 of about 109,445 (330)

Molecular Screening of SCN1A‐Related Seizures in Children With Febrile Seizures: Diagnostic Yield and Variant Distribution

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective SCN1A‐related seizures first present as febrile seizures (FS). Definitive features emerge later, making early diagnosis challenging. We evaluated the diagnostic yield and clinical characteristics of pathogenic SCN1A variants in FS, and analyzed the effect of variant characteristics on clinical phenotypes required for early ...
Jia Wang, Yang‐Yang Wang, Lin‐Yan Hu, Xiu‐Yu Shi, Wen He, Dan Sun, Baoguang Li, Xiaoming Liu, Sanqing Xu, Lijun Du, Chunhui Tang, Li‐Ping Zou   +11 more
wiley   +1 more source

Comparison of Triple Combination Oral Sedation Regimens for Pediatric Dental Treatment [PDF]

, 2019
Purpose: Compare the efficacy of two benzodiazepines (diazepam or midazolam) in combination with meperidine and hydroxyzine for pediatric dental sedation.
Henderson, Brett H
core   +1 more source

Acute and long-term effects of brivaracetam and brivaracetam-diazepam combinations in an experimental model of status epilepticus. [PDF]

, 2017
ObjectiveTo evaluate acute and long-term effects of intravenous brivaracetam (BRV) and BRV + diazepam (DZP) combination treatment in a rat model of self-sustaining status epilepticus (SSSE).MethodsRats were treated with BRV (10 mg/kg) 10 min after ...
Alldredge, Biton, Brophy, Chen, Coeytaux, DeLorenzo, FDA, Gezalian, Gillard, Glauser, Griffin, Klein, Klein, Klein, Klitgaard, Klitgaard, Matagne, Matagne, Mazarati, Mazarati, Mazarati, Naylor, Nicolas, Reagan-Shaw, Ryvlin, Sanchez, Silbergleit, Stockis, Suchomelova, Treiman, Trinka, Wasterlain, Wood   +32 more
core   +1 more source

Intraoral Drug Delivery: Bridging the Gap Between Academic Research and Industrial Innovations

Advanced Functional Materials, EarlyView.
Intraoral drug delivery offers a promising route for systemic and localized therapies, yet challenges such as enzymatic degradation, limited permeability, and microbial interactions hinder efficacy. This figure highlights innovative strategies—mucoadhesive materials, enzyme inhibitors, and permeation enhancers—to overcome these barriers.
Soheil Haddadzadegan, Simona Summonte, Fabrizio Ricci, Matthias Sandmeier, Andreas Bernkop‐Schnürch   +4 more
wiley   +1 more source

Formation of biologically active benzodiazepine metabolites in Arabidopsis thaliana cell cultures and vegetable plants under hydroponic conditions. [PDF]

, 2019
The use of recycled water for agricultural irrigation comes with the concern of exposure to crops by contaminants of emerging concerns (CECs). The concentration of CECs in plant tissues will depend on uptake, translocation and metabolism in plants ...
Dudley, Stacia, Gan, Jay, McGinnis, Michelle, Sun, Chengliang, Trumble, John   +4 more
core   +1 more source

Impact of different anesthetic protocols during anesthesia for the establishment of a porcine model of acute kidney injury

Animal Models and Experimental Medicine, EarlyView.
This study details the adaptations required to establish a long‐term anesthetic protocol in pigs. Three protocols were evaluated, with some causing malignant hyperthermia, hypoglycemia, or hemoynamic instability. The final protocol proved effective for developing a porcine AKI model requiring adequate arterial pressure maintenance.
Axel Guilpin, Mathieu Magnin, Axel Aigle, Timothée Schuhler, Jean‐Yves Ayoub, Romain Lac, Charlotte Slek, Thomas Brichart, Abdessalem Hammed, Vanessa Louzier   +9 more
wiley   +1 more source

Effects Of 4-thiazolidinone Derivatives Les-2658 And Les-1205 On Sleep - Wakefulness Cycle In Kindled Rats [PDF]

, 2017
The research is dedicated to in-depth study of neurotrophic and antiepileptic properties of original potential anticonvulsant agents from 4-thiazolidinones – LES-2658 (5-(3-nitro-benzylidene)-2-(thiazol-2-ylimino)-thiazolidin-4-one) and LES-1205 ([2,4 ...
Lesyk, R. (Roman), Myronenko, S. (Solomija), Pinyazhko, O. (Oleh)   +2 more
core   +2 more sources

Harnessing the multidimensional bioactivity of Chaetomorpha aerea: Integrative phytochemical profiling with in vitro, in vivo, and in silico insights

Animal Models and Experimental Medicine, EarlyView.
This study revealed the antioxidant, anti‐inflammatory, and antidiabetic potentials of the seaweed Chaetomortpha aerea using in vitro, in vivo, and in silico approaches along with phytochemical analysis using gas chromatography–mass spectrometry. ADME/T analysis was also carried out to confirm drug likeness and toxicity prediction.
Md. Mahmudul Hasan, Md. Abdul Alim, Md. Safayat Hossen Momen, Md. Shahidul Islam, Sajjad Hossen Chowdhury, Mohammad Rashed, Fahmina Hoque, S. M. Moazzem Hossen   +7 more
wiley   +1 more source

Comparison of Effectiveness and Side Effects of Diazepam versus Midazolam Administration for Conscious Sedation in Patients Who Underwent Cataract Surgery

Archives of Anesthesia and Critical Care, 2019
Background: The purpose of this study was to compare the effectiveness and side effects of diazepam and midazolam administration for conscious sedation in subjects who undergoing cataract surgery.
Mehdi Sanatkar, Mehrdad Shorooghi, Mohammad Sadegh Sanie   +2 more
doaj   +1 more source

Raja Bandung Banana (Musa ParadisiacaL.cv Raja Bandung) Prevents Increased Systolic Blood Pressure in Rats Given Acute Stress Test [PDF]

, 2015
The relationships between stress and hypertension have been evaluated. Heightened blood pressure (BP) reactions to acute stress have been implicated in cardiovascular disease\u27s development. Consumption of fruit or vegetables lowering BP.
Anindyah, D. S. (Dina), Farmawati, A. (Arta)   +1 more
core   +2 more sources