Conversion of Alkyl Azides to Diazo Compounds and the Azide-Site Selectivity: One-Pot Phosphine-Mediated Transient Protection of Azido Groups and Deprotective Transformation to Diazo Groups [PDF]
A one-pot conversion of alkyl azides to diazo compounds is outlined. After azido group protection of α-azidocarbonyl compounds, treatment of the resulting phosphazides with silica gel in a wet solvent afforded α-diazo carbonyl products by azide ...
Kodai, Tanisawa +3 more
core +2 more sources
Asymmetric formal C–C bond insertion into aldehydes via copper-catalyzed diyne cyclization
Nature Communications, 2023 The formal C–C bond insertion into aldehydes is an attractive methodology for the assembly of homologated carbonyl compounds. However, the homologation of aldehydes has been limited to diazo approach and the enantioselective reaction was rarely developed.
Cui-Ting Li +6 more
doaj +1 more source
Copper-Catalyzed Oxyvinylation of Diazo Compounds [PDF]
Organic Letters, 2020 A copper(I)-catalyzed vinylation of diazo compounds with vinylbenziodoxolone reagents (VBX) as partners is reported. The transformation tolerates diverse functionalities on both reagents delivering polyfunctionalized vinylated products. The strategy was successfully extended to a three-component/intermolecular version with alcohols.
Guillaume Pisella +2 more
openaire +3 more sources
Nature Communications, 2020 Strategies for enantioselective α-aminomethylation of carbonyl compounds rely on the chiral activation of stable ketones substrate. Here, the authors report a rhodium/chiral phosphoric acid cooperative catalysis for the three-component reaction of α ...
Jiuwei Che +4 more
doaj +1 more source
Novas metodologias eficientes para a reação de transferência de diazo: preparação de y-azido-a-diazo-b-ceto éster e aplicações na síntese de amidas e indóis [PDF]
, 2015 Tese (doutorado) - Universidade Federal de Santa Catarina, Centro de Ciências Físicas e Matemáticas, Programa de Pós-Graduação em Química, Florianópolis, 2015.Neste trabalho foram desenvolvidas novas metodologias para a obtenção de diazo compostos 1,3 ...
Dutra, Luiz Gustavo
core
Pd-Catalyzed 1,4-Carboamination of Bromoarenes with Diazo Compounds and Amines [PDF]
, 2022 A palladium-catalyzed 1,4-carboamination of bromoarenes with diazo compounds and amines was developed. This reaction proceeds through a palladium-carbene that then generates a π-benzylpalladium intermediate, forming ipso C–C and para C–N bonds on ...
Junichiro, Yamaguchi +2 more
core +2 more sources
A 3D Multitask Graph Neural Network Framework for Ames Mutagenicity Prediction
Advanced Intelligent Discovery, EarlyView.Our proposed multitask graph neural network model has a high predictive accuracy for Ames mutagenicity. By operating directly on molecular graph representations instead of traditional molecular descriptors, and predicting strain‐specific results, the model outperforms most existing benchmarks.
Abigail E. Teitgen +3 more
wiley +1 more source
Traditional and New methods for the Preparation of Diazocarbonyl Compounds
Anais da Academia Brasileira de Ciências, 2018 For many years diazocarbonyl compounds have been studied due to their versatility and usability in many chemical transformations. In this review, we summarize the traditional methods to prepare these compounds as well as the new methods and recent ...
ANTONIO C.B. BURTOLOSO +2 more
doaj +1 more source
Pyridine Scaffolds, Phenols and Derivatives of Azo Moiety: Current Therapeutic Perspectives
Molecules, 2021 Synthetic heterocyclic compounds have incredible potential against different diseases; pyridines, phenolic compounds and the derivatives of azo moiety have shown excellent antimicrobial, antiviral, antidiabetic, anti-melanogenic, anti-ulcer, anticancer ...
Tehreem Tahir +6 more
doaj +1 more source
Cyclopropanation using flow-generated diazo compounds. [PDF]
, 2015 We have devised a room temperature process for the cyclopropanation of electron-poor olefins using unstabilised diazo compounds, generated under continuous flow conditions.
core +2 more sources