Results 31 to 40 of about 9,657 (231)
O-methyltransferase-like enzyme catalyzed diazo installation in polyketide biosynthesis
Nature Communications, 2023 Diazo compounds are rare natural products possessing various biological activities. Kinamycin and lomaiviticin, two diazo natural products featured by the diazobenzofluorene core, exhibit exceptional potency as chemotherapeutic agents.
Yuchun Zhao +14 more
doaj +1 more source
Hepatology, EarlyView., 2022 Abstract Background and Aims Peroxisome proliferator‐activated receptor α (PPARα) regulates fatty acid transport and catabolism in liver. However, the role of intestinal PPARα in lipid homeostasis is largely unknown. Here, intestinal PPARα was examined for its modulation of obesity and NASH. Approach and Results Intestinal PPARα was activated and fatty
Tingting Yan +22 more
wiley +1 more source
Chemoselective carbene insertion into the N−H bonds of NH3·H2O
Nature Communications, 2022 Converting low-cost inorganic chemicals into value-added organic chemicals is a longstanding goal in chemistry. Here the authors describe a silver-catalysed chemoselective carbene N−H insertion reaction, providing access to primary amines from aqueous ...
Zhaohong Liu +8 more
doaj +1 more source
Electrosynthesis of stabilized diazo compounds from hydrazones [PDF]
, 2022 An electrochemical synthesis of diazo compounds from hydrazones in yields as high as 99% was performed. This method was elaborated as a useful synthetic method and demonstrated on various diazo compounds (24 examples). Apart from exhibiting an efficiency
Caron, Laurent +13 more
core +1 more source
Pd-Catalyzed 1,4-Carboamination of Bromoarenes with Diazo Compounds and Amines
, 2022 A palladium-catalyzed 1,4-carboamination of bromoarenes with diazo compounds and amines was developed. This reaction proceeds through a palladium-carbene that then generates a π-benzylpalladium intermediate, forming ipso C–C and para C–N bonds on ...
Junichiro, Yamaguchi +2 more
core +1 more source
Activation of Diazo Compounds by Fluorinated Triarylborane Catalysts [PDF]
, 2023 The diverse applicability of diazo compounds as versatile reagents has enlarged the chemical toolbox in organic synthesis. Over the past few decades, transition-metal-catalyzed diazo compound activation has ignited the classical synthetic methodology via
Milan Pramanik +3 more
core +1 more source
Mechanochemistry Meets Catalysis: Metal Complexes for Greener Organic Transformations
Angewandte Chemie, EarlyView.Mechanochemistry is redefining metal catalysis by controlling catalyst formulation, speciation, and deployment. This Review shows how milling, LAG, RAM, and TSE enable rapid metal‐complex assembly, distinctive catalytic manifolds, and scalable synthesis beyond solution chemistry.
Sourav Behera +2 more
wiley +2 more sources
Iodine-catalyzed diazo activation to access radical reactivity
Nature Communications, 2018 Radical reactivity of diazo compounds, useful organic building blocks, is yet underexplored. Here, the authors report an iodine-catalyzed radical activation of diazo compounds affording a variety of substituted cyclopropanes, pyrroles and epoxides under ...
Pan Li +5 more
doaj +1 more source
Angewandte Chemie, EarlyView.A catalytic network embedding a formal rearrangement enables the first catalytic enantioselective multicomponent reaction (MCR) of sulfur ylides. In the presence of a bulky chiral phosphoric acid, the reaction combines sulfoxonium ylides, aldehydes and thiols, and affords synthetically versatile β‐hydroxy‐α‐sulfanyl carbonyl compounds in ...
Nicolò Santarelli +10 more
wiley +2 more sources
Synthesis and Antibacterial Activity of Some New Phenothiazine Derivatives
E-Journal of Chemistry, 2007 A series of some new phenothiazine derivatives were synthesized with the objective for evaluation as antimicrobials. The title compounds were prepared by a five step synthesis scheme.
Pawan Kumar Swarnkar +3 more
doaj +1 more source