Results 21 to 30 of about 6,933 (191)

Light‐Controlled Modulation of 15‐Lipoxygenase‐1 Regulates Intestinal Inflammatory Signaling

open access: yesAngewandte Chemie, EarlyView.
The developed target‐guided strategy enables the rational design of diazo‐based photoswitchable inhibitors of 15‐lipoxygenase‐1. Distinct molecular architectures program opposite light‐dependent activity, allowing on‐demand control of enzyme inhibition.
Anastasia Louka   +10 more
wiley   +2 more sources

Iodine-catalyzed diazo activation to access radical reactivity

open access: yesNature Communications, 2018
Radical reactivity of diazo compounds, useful organic building blocks, is yet underexplored. Here, the authors report an iodine-catalyzed radical activation of diazo compounds affording a variety of substituted cyclopropanes, pyrroles and epoxides under ...
Pan Li   +5 more
doaj   +1 more source

Borylcyclopropanes: Synthetic Strategies and Applications

open access: yesAngewandte Chemie, EarlyView.
Borylcyclopropanes (cyclopropanes bearing a boron substituent) sit at the intersection of two privileged frameworks in synthesis. This review provides the first exhaustive survey of their chemistry, spanning metal–carbene, nucleophilic cyclization, radical, hydroboration, and C─H activation routes, and documenting applications in medicinal chemistry ...
Aiza A. Butt, Joseph M. Ready
wiley   +2 more sources

Synthesis and Antibacterial Activity of Some New Phenothiazine Derivatives

open access: yesE-Journal of Chemistry, 2007
A series of some new phenothiazine derivatives were synthesized with the objective for evaluation as antimicrobials. The title compounds were prepared by a five step synthesis scheme.
Pawan Kumar Swarnkar   +3 more
doaj   +1 more source

Copper-catalyzed intermolecular formal (5 + 1) annulation of 1,5-diynes with 1,2,5-oxadiazoles

open access: yesCommunications Chemistry, 2023
One-carbon homologation reactions based on one-carbon insertion into the N−O bond of heterocycles have received tremendous interest over the past decades.
Can-Ming Chen   +6 more
doaj   +1 more source

Ultrasound Assisted Synthesis Of Pyrazolone Derivatives [PDF]

open access: yesمجلة التربية والعلم, 2013
The diazonium salt of 4-amino-1,5-dimethyl-2-phenyl-1H-pyrazol- 2-one (4-aminoantipyrine) was coupled with ethylacetoacetate and ethyl benzoylacetate to give the corresponding diazo compounds under basic media.
Badie Ahmed, Jasim Abdullah
doaj   +1 more source

Catalytic Cycloaddition of Diazo Compounds Based on Pharmacologically Significant and Natural Compounds to C60-Fullerene

open access: yesChemistry Proceedings, 2022
The data obtained by the authors in the field of carbon cluster chemistry, namely, the catalytic cycloaddition of diazo compounds of modern pharmacologically significant and natural compounds to C60-fullerene under the action of complex Pd–catalysts, are
Liliya L. Khuzina   +2 more
doaj   +1 more source

Copper-catalyzed 2,3-dihydro-1,2,4-triazoles synthesis through [3+2]-cycloaddition of nitrile ylides with azodicarboxylates

open access: yesGreen Synthesis and Catalysis
A copper-catalyzed three-component reaction of diazo compounds, nitriles, and azodicarboxylates to construct 2,3-dihydro-1,2,4-triazoles is reported. Key to the success is the utilization of azodicarboxylates to trap the in-situ formed nitrile ylides ...
Bao-Gui Cai, Qian Li, Jun Xuan
doaj   +1 more source

Synthesis and Antibacterial Activity of bis Heterocyclic Derivatives of 1,3,4-thiadiazole

open access: yesIraqi Journal of Pharmaceutical Sciences, 2017
The Chemistry of heterocyclic sulphur and nitrogen containing compounds have a great role in the  field of scientific studies, The 2-amino 5-mercapto-1,3,4-thiadiazole ring for instance, has gained more importance in recent years because  they are ...
Ahlam A. Al-jubouri   +1 more
doaj   +3 more sources

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