Spatiotemporal control in biomedicine: photoswitchable peptides and foldamers
British Journal of Pharmacology, Volume 182, Issue 19, Page 4458-4465, October 2025.Photopharmacology integrates light‐based technology with pharmacology to achieve precise control over biological processes, offering non‐invasive activation and spatiotemporal regulation of biomolecular activity. Within this field, photoswitchable peptides and foldamers provide a powerful approach in precision medicine, enabling reversible ...
Eszter Erdei +5 more
wiley +1 more source
Erweiterung des Repertoires an lichtschaltbaren unnatürlichen Aminosäuren für das Enzym‐Engineering
Angewandte Chemie, Volume 137, Issue 38, September 15, 2025.Enzym‐Engineering mit lichtschaltbaren unnatürlichen Aminosäuren (lsUAs) birgt ein hohes Potenzial für Anwendungen wie die Biokatalyse. Wir erweitern hier das aktuell vorhandene Repertoire mit lsUAs, welche vielseitigere Eigenschaften aufweisen, um den Weg für eine fortschrittlichere Etablierung der Lichtkontrolle in Enzymen zu ebnen. Wir berichten die
Caroline Hiefinger +11 more
wiley +1 more source
6H,12H-5,11-Ethanodibenzo[b,f][1,5]diazocine [PDF]
, 2007 In the molecule of the title compound, C16H16N2, the ethano-strapped analogue of unsubstituted Tröger’s base, the dihedral angle between the two benzene rings is 75.85 (4)°, the smallest angle measured for an ethano-strapped ...
Altomare +14 more
core +5 more sources
Expanding the Repertoire of Photoswitchable Unnatural Amino Acids for Enzyme Engineering
Angewandte Chemie International Edition, Volume 64, Issue 38, September 15, 2025.Enzyme engineering with photoswitchable unnatural amino acids (psUAAs) has a high potential for applications such as biocatalysis. Here, we extend the current repertoire of psUAAs to include more versatile properties paving the way to more advanced photocontrol engineering.
Caroline Hiefinger +11 more
wiley +1 more source
Dimethyl 6H,12H-5,11-methanodibenzo[b,f][1,5]diazocine-2,8-diacetate [PDF]
, 2008 The asymmetric unit of the title compound, C21H22N2O4, a Tröger’s base analogue derived from methyl 4-aminophenylacetate, contains two crystallographically independent molecules with dihedral angles of 88.44 (5) and 88.68 (6)° between the two benzene ...
Andrew C. Try +9 more
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Preparation and Reactions of 1, 5-bis (p-substituted Phenyl) Octahydro-3, 7-Disubstituted-1, 5-Diazocines [PDF]
, 1976 The purpose of this research was to synthesize and study the reactions of 1,5-bis-(p-substituted phenyl)octahydro-3, 7-disubstituted-1, 5-diazocines.
Odle, Roy R.
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Novel photochromic liquid crystals [PDF]
, 2016 The combination of photochromic units and liquid crystal mesogens has over the years been investigated intensively. However the focus of this work has been on very few photochromic groups.
Hussey, James
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Fluorinated Phenylazopyrazoles for Monitoring the Photoisomerization in Complex Systems
Chemistry – A European Journal, Volume 31, Issue 43, August 1, 2025.Fluorinated azopyrazole photoswitches can be obtained in a straightforward synthesis on a wide range of substrates and isomerize efficiently under light‐irradiation. The molecular motion can be followed by 19F‐NMR spectroscopy even in complex systems, such as dopants in vesicles.
Lukas Jakob +7 more
wiley +1 more source
SYNTHESIS OF CYCLIC AZOBENZENE ANALOGUES FOR INCORPORATION INTO OLIGONUCLEOTIDES, PEPTIDES AND POLYMERS [PDF]
, 2014 (A) In recent years, considerable amount of effort has contributed towards enhancing our understanding of the new photoswitch, cyclic azobenzene, particularly from the theoretical point of view.
Joshi, Dhruval Kumar
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Synthetic studies toward A-74528 and synthesis of cyclic azobenzenes [PDF]
, 2020 Part I: Synthetic studies toward A-74528 With thirty carbons A-74528 is one of the two largest type II polyketides known to date. It has a promising bioactivity linked to modulating RNAse L activity and mRNA degradation as part of the innate immune ...
Maier, Martin
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