Results 1 to 10 of about 2,503 (113)

Natural Dibenzo-α-Pyrones and Their Bioactivities [PDF]

Molecules, 2014
Natural dibenzo-α-pyrones are an important group of metabolites derived from fungi, mycobionts, plants and animal feces. They exhibit a variety of biological activities such as toxicity on human and animals, phytotoxicity as well as cytotoxic ...
Daowan Lai, Ligang Zhou, Ziling Mao
exaly   +5 more sources

Bioactive α-Pyrone Derivatives from the Endophytic Fungus Diaporthe sp. CB10100 as Inducible Nitric Oxide Synthase Inhibitors [PDF]

Frontiers in Chemistry, 2021
Inducible nitric oxide synthase (iNOS) produces NO from l-arginine and plays critical roles in inflammation and immune activation. Selective and potent iNOS inhibitors may be potentially used in many indications, such as rheumatoid arthritis, pain, and ...
Hong Pu, Hong Pu, Hong Pu, Jianxin Liu, Yeji Wang, Yuhui Peng, Wanying Zheng, Yang Tang, Boping Hui, Chunmei Nie, Xueshuang Huang, Yanwen Duan, Yanwen Duan, Yanwen Duan, Yong Huang, Yong Huang   +15 more
doaj   +3 more sources

Pd/C-Catalyzed Intramolecular C–H Arylation for the Synthesis of Phenanthridinones and Dibenzo-α-pyrones

SynOpen, 2017
Pd/C was found to be an efficient and convenient metal catalyst for intramolecular C–H arylation reactions in the synthesis of phenanthridinones and dibenzo-α-pyrones. A variety of phenanthridinones and dibenzo-α-pyrones were synthesized under the highly
Lingyu Zhao, Guodong Shen, Tongxin Zhang, Zhen Wang, Yuhua Liang   +4 more
exaly   +4 more sources

ANALGESIC ACTIVITY OF SOME NEW SYNTHETIC DIBENZO-α-PYRONES DERIVATIVES

International Journal of Research in Ayurveda and Pharmacy, 2014
Following standard Hurtley reaction, by using 2 - Bromobenzoic acid, resorcinol and NaOH in the presence of CuSO 4 solution as a catalyst, a clay coloured solid of dibenzo - α - pyrone was prepared. This resulting solid of DBαP was then reacted with various amines respectively, formaldehyde and ethanol and refluxed for 1.5 h as per Mannich reaction ...
Birendra Shrivastava
exaly   +3 more sources

Natural Dibenzo-α-Pyrones: Friends or Foes? [PDF]

International Journal of Molecular Sciences, 2021
Natural dibenzo-α-pyrones (DAPs) can be viewed from two opposite angles. From one angle, the gastrointestinal metabolites urolithins are regarded as beneficial, while from the other, the emerging mycotoxin alternariol and related fungal metabolites are ...
Georg Aichinger, Aichinger Georg
exaly   +3 more sources

Total Syntheses of Sappanin-Based Natural Products Enabled by Pattern Recognition Analysis and Brominative Aromatization. [PDF]

Chem Asian J
A unified synthetic strategy enables the total syntheses of sappanin‐based natural products from a common privileged intermediate derived from cyclic vinylogous esters. Abstract Described is a concise route to caesappins A and B, urolithin C, and protosappanin A, which share a common sappanin core.
Zhao WT, Liang JY, Wu YK.
europepmc   +2 more sources

Combinatory Exposure to Urolithin A, Alternariol, and Deoxynivalenol Affects Colon Cancer Metabolism and Epithelial Barrier Integrity in vitro [PDF]

Frontiers in Nutrition, 2022
The human gastrointestinal tract is an important site of nutrient absorption and a crucial barrier against xenobiotics. It regularly faces “chemical cocktails” composed of food constituents, their human and microbial metabolites, and foodborne ...
Julia Groestlinger, Carina Seidl, Elisabeth Varga, Giorgia Del Favero, Giorgia Del Favero, Doris Marko   +5 more
doaj   +2 more sources

Garcinone E suppresses breast cancer growth and metastasis by modulating tumor‐associated macrophages polarization via STAT6 signaling

Phytotherapy Research, Volume 37, Issue 10, Page 4442-4456, October 2023., 2023
Abstract Cancer metastasis remains the most common cause of death in breast cancer patients. Tumor‐associated macrophages (TAMs) are a novel therapeutic target for the treatment of metastatic breast cancer. Despite the good anti‐cancer activity of garcinone E (GE), there are no reports on its therapeutic effects on breast cancer metastasis.
Xin Nie, Li Fu, Yanfen Cheng, Xiaoping Wu, Kongpeng Lv, Renkai Li, Yihan Wu, George Pak‐Heng Leung, Chaomei Fu, Simon Ming‐Yuen Lee, Sai‐Wang Seto, Jinming Zhang, Jingjing Li   +12 more
wiley   +1 more source

Targeting mitochondrial quality control in muscle aging: Natural dietary products as potential interventions

Food Frontiers, Volume 4, Issue 3, Page 1206-1241, September 2023., 2023
Natural dietary products targeting the MQC network as antiaging agents for different types of muscle. Abstract Mitochondria are the main sources of energy production for muscle tissues, including skeletal, cardiac, or smooth muscle, to support their activities. Mitochondrial dysfunction and dysregulation of their quality control systems are significant
Qi Chen, Weisu Huang, Esra Capanoglu, Amel Thanina Amrouche, Baiyi Lu   +4 more
wiley   +1 more source

Physiologically‐Based Pharmacokinetic Modeling of the Postbiotic Supplement Urolithin A Predicts its Bioavailability Is Orders of Magnitude Lower than Concentrations that Induce Toxicity, but also Neuroprotective Effects

Molecular Nutrition &Food Research, Volume 67, Issue 15, August 2023., 2023
A physiologically‐based pharmacokinetic model for urolithin A that includes uptake, metabolism and dissolution kinetics is constructed. It is evaluated against human data and then used to predict plasma and tissue concentrations of UA and its glucuronides.
Georg Aichinger, Maja Stevanoska, Karsten Beekmann, Shana J. Sturla   +3 more
wiley   +1 more source