Results 11 to 20 of about 283 (127)

Total Syntheses of Sappanin-Based Natural Products Enabled by Pattern Recognition Analysis and Brominative Aromatization. [PDF]

open access: yesChem Asian J
A unified synthetic strategy enables the total syntheses of sappanin‐based natural products from a common privileged intermediate derived from cyclic vinylogous esters. Abstract Described is a concise route to caesappins A and B, urolithin C, and protosappanin A, which share a common sappanin core.
Zhao WT, Liang JY, Wu YK.
europepmc   +2 more sources

Emerging Fusarium and Alternaria mycotoxins : occurrence, toxicity and toxicokinetics [PDF]

open access: yes, 2017
Emerging Fusarium and Alternaria mycotoxins gain more and more interest due to their frequent contamination of food and feed, although in vivo toxicity and toxicokinetic data are limited.
Antonissen, Gunther   +3 more
core   +6 more sources

Garcinone E suppresses breast cancer growth and metastasis by modulating tumor‐associated macrophages polarization via STAT6 signaling

open access: yesPhytotherapy Research, Volume 37, Issue 10, Page 4442-4456, October 2023., 2023
Abstract Cancer metastasis remains the most common cause of death in breast cancer patients. Tumor‐associated macrophages (TAMs) are a novel therapeutic target for the treatment of metastatic breast cancer. Despite the good anti‐cancer activity of garcinone E (GE), there are no reports on its therapeutic effects on breast cancer metastasis.
Xin Nie   +12 more
wiley   +1 more source

Targeting mitochondrial quality control in muscle aging: Natural dietary products as potential interventions

open access: yesFood Frontiers, Volume 4, Issue 3, Page 1206-1241, September 2023., 2023
Natural dietary products targeting the MQC network as antiaging agents for different types of muscle. Abstract Mitochondria are the main sources of energy production for muscle tissues, including skeletal, cardiac, or smooth muscle, to support their activities. Mitochondrial dysfunction and dysregulation of their quality control systems are significant
Qi Chen   +4 more
wiley   +1 more source

An updated overview of anticancer effects of alternariol and its derivatives: Underlying molecular mechanisms [PDF]

open access: yes, 2023
Alternariol is a toxic metabolite of Alternaria fungi and studies have shown multiple potential pharmacological effects. To outline the anticancer effects and mechanisms of alternariol and its derivatives based on database reports, an updated search of ...
Ahmad Faizal Abdull Razis   +10 more
core   +2 more sources

Physiologically‐Based Pharmacokinetic Modeling of the Postbiotic Supplement Urolithin A Predicts its Bioavailability Is Orders of Magnitude Lower than Concentrations that Induce Toxicity, but also Neuroprotective Effects

open access: yesMolecular Nutrition &Food Research, Volume 67, Issue 15, August 2023., 2023
A physiologically‐based pharmacokinetic model for urolithin A that includes uptake, metabolism and dissolution kinetics is constructed. It is evaluated against human data and then used to predict plasma and tissue concentrations of UA and its glucuronides.
Georg Aichinger   +3 more
wiley   +1 more source

Oxidative N‐Heterocyclic Carbene Catalysis

open access: yesChemistry – A European Journal, Volume 29, Issue 4, January 18, 2023., 2023
The advances in oxidative N‐heterocyclic carbene (NHC)‐catalysis are reviewed according to the strategies that rely on typical NHC‐bound intermediates, including acyl/imidoyl azolium, α,β‐unsaturated acyl azolium, and azolium peroxide species, as well as NHC‐derived ortho‐quinone methide (o‐QM), aza‐fulvene, and triaza‐diene intermediates, with ...
Carmela De Risi   +5 more
wiley   +1 more source

Xanthones and Xanthone O‐β‐D‐Glucosides from the Roots of Polygala azizsancarii Dönmez

open access: yesChemistry &Biodiversity, Volume 19, Issue 8, August 2022., 2022
Abstract Nine xanthone derivatives (1–9) were isolated from the roots of Polygala azizsancarii, which is a narrow endemic species for the flora of Türkiye. Based on all of the evidence, the structures of 1–9 were established as two previously undescribed xanthone O‐glucosides, 3‐O‐β‐D‐glucopyranosyloxy‐1,6‐dihydroxy‐2,5,7‐trimethoxyxanthone (1), 3‐O‐β ...
İhsan Çalış   +6 more
wiley   +1 more source

Humic acid from Shilajit – a physico-chemical and spectroscopic characterization [PDF]

open access: yes, 2009
Shilajit is a blackish–brown exudation, consisting of organic substances, metal ions and minerals, from different formations, commonly found in the Himalayan region (1000–3000 m) from Nepal to Kashmir.
ASGAR ALI   +4 more
core   +1 more source

Persistence of the antagonistic effects of a natural mixture of Alternaria mycotoxins on the estrogen-like activity of human feces after anaerobic incubation [PDF]

open access: yes, 2022
Several Alternaria mycotoxins are believed to act as endocrine disruptive chemicals (EDCs), since they are reported to bind estrogen receptors in several experimental models.
Aichinger, Georg   +8 more
core   +1 more source

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