Results 11 to 20 of about 82 (78)

Analogs of phenothiazines. 5. Synthesis and neuropharmacological activity of some piperidylidene derivatives of thioxanthenes, xanthenes, dibenzoxepins, and acridans

Journal of Medicinal Chemistry, 1974
Andrew J. Saggiomo, Edward A. Nodiff, Philip J. Fowler, Bruce M. Lester, Charles L. Zirkle, Carl Kaiser, David H. Tedeschi, Eleanor Garvey   +7 more
core   +3 more sources

Enzymatic Optical Resolution of Dibenzoxepins and Its Application to an Optically Active Antiallergic Agent with Thromboxane A₂Receptor Antagonistic Activity

Bioscience, Biotechnology, and Biochemistry, 1993
Methyl (+/-)-11-(2-hydroxyethyl)thio-6,11-dihydrodibenz[b,e]oxepin- 2- carboxylate (5) was enantio-selectively acylated with acetic anhydride in an organic medium by Lipase Amano P to give methyl (-)-11-(2-acetoxyethyl)thio-6,11-dihydrodibenz[b,e]oxepin-2- carboxylate (8), and the (+)-enantiomer by Lipase Sigma Type VII. Using Lipase Amano P, (+)- and (
Yukihiro Kuge, Toru Sugaya, Kenji Shioga, Shinji Tomioka   +3 more
core   +3 more sources

Double Heck Route to a Dibenzoxepine and Convergent Suzuki Cross-Coupling Strategy for the Synthesis of an MR Antagonist

Organic Process Research & Development, 2016
Abstract A practical pilot plant convergent synthesis of MR antagonist LY2623091 was established. For synthesis convergence, a vinyl bromide geometric isomer and chiral alaninol derivative were required building blocks. Key to the synthesis route development is a stereoselective synthesis of the E-vinyl bromide via a sequential double
Marvin M. Hansen, Neil J. Kallman, Thomas M. Koenig, Ryan J. Linder, Rachel N. Richey, John R. Rizzo, Jeffrey A. Ward, Hannah Yu, Tony Y. Zhang, David Mitchell   +9 more
openaire   +1 more source

SYNTHESIS, CHARACTERIZATION AND PHARMACOLOGICAL EVALUATION OF STRUCTURALLY RELATED COMPOUNDS OF DIBENZOXEPIN AND DIBENZOTHIEPIN

INTERNATIONAL RESEARCH JOURNAL OF PHARMACY, 2014
This study was designed to synthesize, characterize and to evaluate the pharmacological activity of Dibenzoxepin and Dibenzothiepin derivatives. Totally three compounds, two Dibenzoxepin derivatives and one Dibenzothiepin derivative were synthesized by conventional method.
openaire   +1 more source

Effects of KW-3635, a Novel Dibenzoxepin Derivative of a Selective Thromboxane A2 Antagonist, on Human, Guinea Pig and Rat Platelets

Japanese Journal of Pharmacology, 1992
We examined the binding of [3H]U-46619, a thromboxane A2 agonist, to human and guinea pig platelets and the binding of [3H]SQ 29,548, a thromboxane A2 antagonist, to human, rat and guinea pig platelets. KW-3635 (sodium (E)-11-[2-(5,6-dimethyl-1- benzimidazolyl)ethylidene]-6,11-dihydrodibenz[b,e]oxepin-2-c arboxylate monohydrate) concentration ...
Miki, Ichiro, Kishibayashi, Nobuyuki, Nonaka, Hiromi, Ohshima, Etsuo, Takami, Hitoshi, Obase, Hiroyuki, Ishii, Akio   +6 more
openaire   +2 more sources

Lichen-derived caperatic acid and physodic acid inhibit Wnt signaling in colorectal cancer cells. [PDF]

Mol Cell Biochem, 2018
Paluszczak J, Kleszcz R, Studzińska-Sroka E, Krajka-Kuźniak V.   +3 more
europepmc   +1 more source

A new dibenz[b,e]oxepine derivative, 1-hydroxy-10-methoxy-dibenz[b,e]oxepin-6,11-dione, from a marine-derived fungus, Beauveria bassiana TPU942. [PDF]

Mar Drugs, 2012
Yamazaki H, Rotinsulu H, Kaneko T, Murakami K, Fujiwara H, Ukai K, Namikoshi M.   +6 more
europepmc   +1 more source

In vitro effects of preserved and unpreserved anti-allergic drugs on human corneal epithelial cells. [PDF]

J Ocul Pharmacol Ther, 2014
Guzman-Aranguez A, Calvo P, Ropero I, Pintor J.   +3 more
europepmc   +1 more source

ChemInform Abstract: Substituent Effects in the Induction of a Cholesteric Liquid Crystal Phase by Atropisomeric Dibenzoxepins: A Study of Arene-Arene Interactions.

, 2010
R. P. LEMIEUX, V. E. WILLIAMS
core   +1 more source

Crystal structure-based discovery of a novel synthesized PARP1 inhibitor (OL-1) with apoptosis-inducing mechanisms in triple-negative breast cancer. [PDF]

Sci Rep, 2016
Fu L, Wang S, Wang X, Wang P, Zheng Y, Yao D, Guo M, Zhang L, Ouyang L.   +8 more
europepmc   +1 more source