Results 31 to 40 of about 76 (75)

P-5227: an active dibenzoxepine antipsychotic.

Current therapeutic research, clinical and experimental, 1966
A A, Sugerman, F J, Lichtigfeld
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Recent Advances on the Development of Synthetic Strategies to Access Dibenzoxepine Derivatives

Synthesis, 2022
AbstractDibenzoxepines have gained privileged status in medicinal chemistry and drug discovery due to their appearance in various natural products and life-saving drug molecules. Dibenzoxepine-based molecules, such as artocarpols, asenapine, and pacharin, possess a wide range of biological activities including anti-inflammatory, antidepressant ...
Surisetti Suresh, Sanjay Yadav, Jakkula Ramarao   +2 more
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Synthesis of antimicrotubule dibenzoxepines

Tetrahedron Letters, 2010
Abstract New dibenzoxepines 5a–i bearing various substituents on B- and C-rings were synthesized in a straightforward manner using a Suzuki–Miyaura coupling, a Grignard addition, and a cyclodehydration as key steps. The antimicrotubule activity of all analogues was evaluated and compared to reference compounds.
Colombel, V., Joncour, A., Thoret, S., Dubois, Joëlle, Bignon, J., Wdzieczak-Bakala, J., Baudoin, O.   +6 more
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Dibenzoxepines as treatments for neurodegenerative diseases

Pure and Applied Chemistry, 1999
Abstract
Kaspar Zimmermann, P. C. Waldmeier, W. G. Tatton   +2 more
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Solvent-specific, DAST-mediated intramolecular Friedel–Crafts reaction: access to dibenzoxepine-fused spirooxindoles

Organic & Biomolecular Chemistry, 2021
DAST-mediated intramolecular Friedel–Crafts cyclization is developed for the synthesis of novel spirooxindoles fused with dibenzoxepine moieties.
Ramesh Samikannu, Sankaranarayanan Sethuraman, Nagaraja Akula, Vignesh Radhakrishnan, Srinivasarao Kamisetti, Shabana Banu, Muthalagu Vetrichelvan, Anuradha Gupta, Jianqing Li, Richard Rampulla, Arvind Mathur   +10 more
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Exciting progress in the transition metal‐catalyzed synthesis of oxepines, benzoxepines, dibenzoxepines, and other derivatives

Applied Organometallic Chemistry, 2021
AbstractFrom the past decade so far, the synthesis of seven‐membered oxacycles especially natural monocyclic oxepines and their annulated derivatives has received considerable attention. Due to the importance of these valuable scaffolds in natural products, pharmaceuticals, and prospective drugs, as well as their strong potential for use in the ...
Fatemeh Rafiee, Samira Hasani
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A Synthetic Route to (±)-Clavizepine through a Dibenzoxepine Intermediate

The Journal of Organic Chemistry, 1996
A new synthesis of (±)-clavizepine (1a), based on the dibenzoxepinediol 10 as main intermediate is described. The key step is the contraction of the oxepine ring to give the xanthene-9-carboxyaldehyde 11, on which the nitrogenated ring can be readily assembled.
M. C. de la Fuente, Luis Castedo, Domingo Domínguez   +2 more
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The synthesis of pacharin: a dibenzoxepine from the heartwood of Bauhinia racemosa Lamk.

Journal of the Chemical Society, Perkin Transactions 1, 1990
The synthesis of the novel dibenzoxepine derivative pacharin (13)(8-methoxy-7-methyldibenz[b,f]-oxepine-1,6-diol), a constituent of the heartwood of Bauhinia racemosa Lamk., is described The route depended on the formation of the diphenyl ether (8) which was converted by standard synthetic steps into the bisphosphonium salt (11).
Mark F. Comber, Melvyn V. Sargent
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Total synthesis of cularine alkaloids via dibenzoxepines as key intermediates

Tetrahedron, 1995
Abstract The total synthesis of several cularine alkaloids (cularine, oxocularine, dioxocularine and 4-hydroxycularine) via 10,11-dihydrodibenz(b,f)oxepin-10-ones as key intermediates is reported.
Alberto Garcia, Luis Castedo, Domingo Domínguez   +2 more
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ChemInform Abstract: A Synthetic Route to (.+‐.)‐Clavizepine Through a Dibenzoxepine Intermediate.

ChemInform, 1997
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
M. C. DE LA FUENTE, L. CASTEDO, D. DOMINGUEZ   +2 more
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