Results 31 to 40 of about 82 (78)

Local buccal mucosal effects of aspirin, indomethacin and isoxepac: their relationship to gastrointestinal damage. [PDF]

Br J Clin Pharmacol, 1981
Huston GJ.
europepmc   +1 more source

P118 unexpected results in attempted synthesis of pyridazine congeners of dibenzoxepines, dibenzthiepines and dibenzdiazepines

European Journal of Pharmaceutical Sciences, 1994
G. Heinisch, B. Matuszczak, K. Mereiter, J. Soder   +3 more
openaire   +1 more source

Haemodynamic effects of BM 10.188, a new orally active inotropic agent, in healthy volunteers. [PDF]

Br J Clin Pharmacol, 1982
Whiting B, Kelman AW, Sumner DJ, Hillis WS, Ledermann H.   +4 more
europepmc   +1 more source

KW-4679-induced inhibition of tachykininergic contraction in the guinea-pig bronchi by prejunctional inhibition of peripheral sensory nerves. [PDF]

Br J Pharmacol, 1996
Ikemura T, Okarmura K, Sasaki Y, Ishi H, Ohmori K.   +4 more
europepmc   +1 more source

P-5227: an active dibenzoxepine antipsychotic.

Current therapeutic research, clinical and experimental, 1966
A A, Sugerman, F J, Lichtigfeld
openaire   +1 more source

Recent Advances on the Development of Synthetic Strategies to Access Dibenzoxepine Derivatives

Synthesis, 2022
AbstractDibenzoxepines have gained privileged status in medicinal chemistry and drug discovery due to their appearance in various natural products and life-saving drug molecules. Dibenzoxepine-based molecules, such as artocarpols, asenapine, and pacharin, possess a wide range of biological activities including anti-inflammatory, antidepressant ...
Surisetti Suresh, Sanjay Yadav, Jakkula Ramarao   +2 more
openaire   +1 more source

Synthesis of antimicrotubule dibenzoxepines

Tetrahedron Letters, 2010
Abstract New dibenzoxepines 5a–i bearing various substituents on B- and C-rings were synthesized in a straightforward manner using a Suzuki–Miyaura coupling, a Grignard addition, and a cyclodehydration as key steps. The antimicrotubule activity of all analogues was evaluated and compared to reference compounds.
Colombel, V., Joncour, A., Thoret, S., Dubois, Joëlle, Bignon, J., Wdzieczak-Bakala, J., Baudoin, O.   +6 more
openaire   +2 more sources

Dibenzoxepines as treatments for neurodegenerative diseases

Pure and Applied Chemistry, 1999
Abstract
Kaspar Zimmermann, P. C. Waldmeier, W. G. Tatton   +2 more
openaire   +1 more source

Solvent-specific, DAST-mediated intramolecular Friedel–Crafts reaction: access to dibenzoxepine-fused spirooxindoles

Organic & Biomolecular Chemistry, 2021
DAST-mediated intramolecular Friedel–Crafts cyclization is developed for the synthesis of novel spirooxindoles fused with dibenzoxepine moieties.
Ramesh Samikannu, Sankaranarayanan Sethuraman, Nagaraja Akula, Vignesh Radhakrishnan, Srinivasarao Kamisetti, Shabana Banu, Muthalagu Vetrichelvan, Anuradha Gupta, Jianqing Li, Richard Rampulla, Arvind Mathur   +10 more
openaire   +2 more sources

A Synthetic Route to (±)-Clavizepine through a Dibenzoxepine Intermediate

The Journal of Organic Chemistry, 1996
A new synthesis of (±)-clavizepine (1a), based on the dibenzoxepinediol 10 as main intermediate is described. The key step is the contraction of the oxepine ring to give the xanthene-9-carboxyaldehyde 11, on which the nitrogenated ring can be readily assembled.
M. C. de la Fuente, Luis Castedo, Domingo Domínguez   +2 more
openaire   +1 more source