Results 1 to 10 of about 286,478 (209)

Antiplatelet properties of Pim kinase inhibition are mediated through disruption of thromboxane A2 receptor signaling [PDF]

Haematologica, 2020
Pim kinases are upregulated in several forms of cancer, contributing to cell survival and tumour development, but their role in platelet function and thrombotic disease has not been explored. We report for the first time that Pim-1 is expressed in human
Amanda J. Unsworth, Alexander P. Bye, Tanya Sage, Renato S. Gaspar, Nathan Eaton, Caleb Drew, Alexander Stainer, Neline Kriek, Peter J. Volberding, James L. Hutchinson, Ryan Riley, Sarah Jones, Stuart J. Mundell, Weiguo Cui, Hervé Falet, Jonathan M. Gibbins   +15 more
doaj   +3 more sources

Treatment of COVID-19 Pneumonia and Acute Respiratory Distress With Ramatroban, a Thromboxane A2 and Prostaglandin D2 Receptor Antagonist: A Four-Patient Case Series Report [PDF]

Frontiers in Pharmacology, 2022
Hypoxemia in COVID-19 pneumonia is associated with hospitalization, mechanical ventilation, and mortality. COVID-19 patients exhibit marked increases in fatty acid levels and inflammatory lipid mediators, predominantly arachidonic acid metabolites ...
Martin L. Ogletree, Kate Chander Chiang, Rashmi Kulshrestha, Aditya Agarwal, Aditya Agarwal, Ashutosh Agarwal, Ashutosh Agarwal, Ajay Gupta, Ajay Gupta   +8 more
doaj   +2 more sources

Preeclampsia and aspirin [PDF]

Obstetrics & Gynecology Science, 2023
Preeclampsia (PE) is a multisystem disorder that is an important cause of maternal and perinatal deaths. Currently, delivery is the only final treatment for PE.
Tae Gyu Ahn, Jong Yun Hwang
doaj   +1 more source

SARS-CoV-2 vaccination induced cerebral venous sinus thrombosis: Do megakaryocytes, platelets and lipid mediators make up the orchestra?

Free Neuropathology, 2021
The COVID-19 vaccines comprised of adenoviral vectors encoding the Spike (S) glycoprotein of SARS-CoV-2 are highly effective but associated with rare thrombotic complications.
Kate Chander Chiang, Ravi Raghavan, Ajay Gupta   +2 more
doaj   +1 more source

Contemporary management of pain in cirrhosis: Toward precision therapy for pain

Hepatology, EarlyView., 2022
Abstract Chronic pain is highly prevalent in patients with cirrhosis and is associated with poor health‐related quality of life and poor functional status. However, there is limited guidance on appropriate pain management in this population, and pharmacologic treatment can be harmful, leading to adverse outcomes, such as gastrointestinal bleeding ...
Alexis Holman, Neehar Parikh, Dan J. Clauw, David A. Williams, Elliot B. Tapper   +4 more
wiley   +1 more source

Group VIB calcium-independent phospholipase A2 (iPLA2γ) regulates platelet activation, hemostasis and thrombosis in mice. [PDF]

PLoS ONE, 2014
In platelets, group IVA cytosolic phospholipase A2 (cPLA2α) has been implicated as a key regulator in the hydrolysis of platelet membrane phospholipids, leading to pro-thrombotic thromboxane A2 and anti-thrombotic 12-(S)-hydroxyeicosatetranoic acid ...
Emiko Yoda, Kohmi Rai, Mai Ogawa, Yuki Takakura, Hiroshi Kuwata, Hidenori Suzuki, Yoshihito Nakatani, Makoto Murakami, Shuntaro Hara   +8 more
doaj   +1 more source

Increased Levels of Txa2 Induced by Dengue Virus Infection in IgM Positive Individuals Is Related to the Mild Symptoms of Dengue

Viruses, 2018
The inflammatory process plays a major role in the prognosis of dengue. In this context, the eicosanoids may have considerable influence on the regulation of the Dengue virus-induced inflammatory process.
Eneida S. Oliveira, Stella G. Colombarolli, Camila S. Nascimento, Izabella C. A. Batista, Jorge G. G. Ferreira, Daniele L. R. Alvarenga, Laís O. B. de Sousa, Rafael R. Assis, Marcele N. Rocha, Érica A. R. Alves, Carlos E. Calzavara-Silva   +10 more
doaj   +1 more source

Skepinone-L, a Novel Potent and Highly Selective Inhibitor of p38 MAP Kinase, Effectively Impairs Platelet Activation and Thrombus Formation

Cellular Physiology and Biochemistry, 2013
Background/Aims: Platelets are critically important for primary haemostasis and the major players in thrombotic vascular occlusion. Platelets are activated by agonists, such as thrombin and collagen-related peptide as well as second-wave mediators ...
Oliver Borst, Britta Walker, Patrick Münzer, Antonella Russo, Evi Schmid, Caterina Faggio, Boris Bigalke, Stefan Laufer, Meinrad Gawaz, Florian Lang   +9 more
doaj   +1 more source

ADP and Thromboxane Inhibitors Both Reduce Global Contraction of Clot Length, While Thromboxane Inhibition Attenuates Internal Aggregate Contraction

TH Open, 2022
Platelet contractility drives clot contraction to enhance clot density and stability. Clot contraction is typically studied under static conditions, with fewer studies of wall-adherent platelet clots formed under flow.
Kevin T. Trigani, Michael E. DeCortin, Scott L. Diamond   +2 more
doaj   +1 more source

TULA-2 Deficiency Enhances Platelet Functional Responses to CLEC-2 Agonists

TH Open, 2018
Platelet activation is essential for hemostasis. Central to platelet activation are the signals transmitted through surface receptors such as glycoprotein VI, the protease-activated receptors, and C-type lectin-like receptor 2 (CLEC-2).
John C. Kostyak, Benjamin R. Mauri, Carol Dangelmaier, Akruti Patel, Yuhang Zhou, Johannes A. Eble, Alexander Y. Tsygankov, Steven E. McKenzie, Satya P. Kunapuli   +8 more
doaj   +1 more source