Results 1 to 10 of about 9,316 (155)

P2X receptors and lipids interact to modulate inflammation [PDF]

Journal of Lipid Research
P2X receptors are purinergic receptors activated in the presence of extracellular ATP. These receptors are involved in the pathogenesis of various diseases, including inflammatory diseases, and are also associated with pain.
Vitor Nascimento Vidal, Thalita Calvet Pereira, Guilherme Pegas Teixeira, Leandro Rocha, Robson Xavier Faria   +4 more
doaj   +2 more sources

The COX Pathway Alters Hematopoiesis in Hashimoto’s Thyroiditis [PDF]

Cells
Introduction: There is limited data in the literature on the effect of prostaglandins (PG) and thromboxanes (TX) on the development and severity of Hashimoto’s Thyroiditis (HT).
Karolina Wrońska, Maciej Ziętek, Magdalena Marciniak, Małgorzata Szczuko   +3 more
doaj   +2 more sources

Comprehensive Metabolomics in Mouse Mast Cell Model of Allergic Rhinitis for Profiling, Modulation, Semiquantitative Analysis, and Pathway Analysis [PDF]

Biomolecules
Allergic rhinitis affects millions globally, causing significant discomfort and reducing the quality of life. This study investigates the metabolic alterations in murine mast cells (MC/9) under allergic rhinitis conditions induced by lipopolysaccharide ...
Akshay Suresh Patil, Yan Xu
doaj   +2 more sources

The beneficial effect of sulforaphane on platelet responsiveness during caloric load: a single-intake, double-blind, placebo-controlled, crossover trial in healthy participants

Frontiers in Nutrition, 2023
Background and aimsAs our understanding of platelet activation in response to infections and/or inflammatory conditions is growing, it is becoming clearer that safe, yet efficacious, platelet-targeted phytochemicals could improve public health beyond the
Hidde P. van Steenwijk, Evi Winter, Edward Knaven, Jos F. Brouwers, Myrthe van Baardwijk, Myrthe van Baardwijk, Jasper B. van Dalum, Teus J. C. Luijendijk, Frits H. M. van Osch, Frits H. M. van Osch, Freddy J. Troost, Freddy J. Troost, Aalt Bast, Aalt Bast, Khrystyna O. Semen, Alie de Boer   +15 more
doaj   +1 more source

Eicosanoids in the Pancreatic Tumor Microenvironment—A Multicellular, Multifaceted Progression

Gastro Hep Advances, 2022
Background and Aims: Eicosanoids, oxidized fatty acids that serve as cell-signaling molecules, have been broadly implicated in tumorigenesis. Here, we aimed to identify eicosanoids associated with pancreatic tumorigenesis and the cell types responsible ...
Vikas B. Gubbala, Nidhi Jytosana, Vincent Q. Trinh, H. Carlo Maurer, Razia F. Naeem, Nikki K. Lytle, Zhibo Ma, Steven Zhao, Wei Lin, Haiyong Han, Yu Shi, Tony Hunter, Pankaj K. Singh, Kenneth P. Olive, Marcus C.B. Tan, Susan M. Kaech, Geoffrey M. Wahl, Kathleen E. DelGiorno   +17 more
doaj   +1 more source

Membrane Lipid Derivatives: Roles of Arachidonic Acid and Its Metabolites in Pancreatic Physiology and Pathophysiology

Molecules, 2023
One of the most important constituents of the cell membrane is arachidonic acid. Lipids forming part of the cellular membrane can be metabolized in a variety of cellular types of the body by a family of enzymes termed phospholipases: phospholipase A2 ...
Cándido Ortiz-Placín, Alba Castillejo-Rufo, Matías Estarás, Antonio González   +3 more
doaj   +1 more source

Eicosanoids in inflammation in the blood and the vessel

Frontiers in Pharmacology, 2022
Polyunsaturated fatty acids (PUFAs) are structural components of membrane phospholipids in cells. PUFAs regulate cellular function through the formation of derived lipid mediators termed eicosanoids.
Adriana Yamaguchi, Eliana Botta, Michael Holinstat, Michael Holinstat   +3 more
doaj   +1 more source

Dazhu Hongjingtian Preparation as Adjuvant Therapy for Unstable Angina Pectoris: A Meta-Analysis of Randomized Controlled Trials

Frontiers in Pharmacology, 2020
Objective: Dazhu hongjingtian [DZHJT, Rhodiola wallichiana var. cholaensis (Praeger) S.H. Fu] preparation as an add-on therapy has been applied to the treatment of angina pectoris. We aimed to evaluate the efficacy and safety of DZHJT as adjuvant therapy
Changfeng Man, Zhe Dai, Yu Fan
doaj   +1 more source

Quantitative metabolic profiling of urinary eicosanoids for clinical phenotyping

Journal of Lipid Research, 2019
The eicosanoids are a family of lipid mediators of pain and inflammation involved in multiple pathologies, including asthma, hypertension, cancer, atherosclerosis, and neurodegenerative diseases.
Cristina Gómez, Carolina Gonzalez-Riano, Coral Barbas, Johan Kolmert, Min Hyung Ryu, Christopher Carlsten, Sven-Erik Dahlén, Craig E. Wheelock   +7 more
doaj   +1 more source

Thromboxane and the thromboxane receptor in cardiovascular disease [PDF]

Clinical Lipidology, 2010
Thromboxane A(2) (TXA(2)), the primary product of COX-1-dependent metabolism of arachidonic acid, mediates its biological actions through the TXA(2) receptor, termed the TP. Irreversible inhibition of platelet COX-1-derived TXA(2) with low-dose aspirin affords protection against primary and secondary vascular thrombotic events, underscoring the central
openaire   +2 more sources