Results 41 to 50 of about 9,969 (239)

The arachidonic acid cascade. The prostaglandins, thromboxanes and leukotrienes

, 1984
Certain polyunsaturated fatty acids, such as arachidonic acid, are metabolized by oxygenation into a large family of biologically active substances, the prostanoids.
Granström, E
core   +1 more source

Safety and Feasibility of Magnetic Separation‐Based Blood Purification

Advanced NanoBiomed Research, EarlyView.
We present the preclinical biological safety and translational feasibility of a magnetic nanoparticle‐based extracorporeal blood purification platform for removal of disease‐causing blood factors. ISO 10993‐compliant studies and exaggerated worst‐case exposure models demonstrate efficient nanoparticle extraction (≥99.9%), favorable biocompatibility ...
Carlos A. Mora, Laurine Rijsbergen, Jan Waskowski, Gaelle Clermont, Florian Dingreville, Chandrashekara Vishwanath, Rajesh Karunanithi, Alexander Gogos, Jean‐Claude Metzger, Manuel Baumgartner, Joerg C. Schefold, Inge K. Herrmann   +11 more
wiley   +1 more source

Reversal of stress fibre formation by Nitric Oxide mediated RhoA inhibition leads to reduction in the height of preformed thrombi

Scientific Reports, 2018
Evidence has emerged to suggest that thrombi are dynamic structures with distinct areas of differing platelet activation and inhibition. We hypothesised that Nitric oxide (NO), a platelet inhibitor, can modulate the actin cytoskeleton reversing platelet ...
L. Atkinson, M. Z. Yusuf, A. Aburima, Y. Ahmed, S. G. Thomas, K. M. Naseem, S. D. J. Calaminus   +6 more
doaj   +1 more source

Commonalities of platelet dysfunction in heart failure with preserved ejection fraction and underlying comorbidities

ESC Heart Failure, Volume 12, Issue 2, Page 1013-1028, April 2025.
Abstract Heart failure with preserved ejection fraction (HFpEF) is characterized by a lack of a specific targeted treatment and a complex, partially unexplored pathophysiology. Common comorbidities associated with HFpEF are hypertension, atrial fibrillation, obesity and diabetes.
Giorgia D'Italia, Blanche Schroen, Judith M.E.M. Cosemans   +2 more
wiley   +1 more source

PCOS: A Chronic Disease That Fails to Produce Adequately Specialized Pro-Resolving Lipid Mediators (SPMs)

Biomedicines, 2022
Introduction: Polycystic ovary syndrome (PCOS) is an endocrinological disorder that affects 5–15% of women of their reproductive age and is a frequent cause of infertility. Major symptoms include hyperandrogenism, ovulatory dysfunction, and often obesity
Pedro-Antonio Regidor, Xavier de la Rosa, Anna Müller, Manuela Mayr, Fernando Gonzalez Santos, Rafael Gracia Banzo, Jose Miguel Rizo   +6 more
doaj   +1 more source

Assay Methods for Prostaglandins and Thromboxanes: Gas Chromatographic — Mass Spectrometric Methods and Radioimmunoassay

, 1981
The metabolites of polyunsaturated fatty acids constitute a large and steadily growing family of compounds, with the classical prostaglandins as the first identified members, and the thromboxanes, prostacyclins and leukotrienes as more recently ...
Granström, E, Elisabeth Granström
core   +1 more source

Dexmedetomidine infusions improve cardiovascular and renal function in anaesthetised, experimentally endotoxaemic horses

Equine Veterinary Journal, EarlyView.
Abstract Background Dexmedetomidine infusions are beneficial in anaesthetised endotoxaemic horses when administered concurrent to endotoxin, but post‐conditioning effects are unknown. Objectives To evaluate whether a dexmedetomidine infusion is beneficial in horses administered Escherichia coli O55:B5 lipopolysaccharides (LPS) endotoxin prior to ...
Sera Lee, Rachel C. Hector, Lynn Pezzanite, Eric Gilleland, Marlis L. Rezende   +4 more
wiley   +1 more source

Carrageenan-induced activation of human platelets is independent of phospholipase A2 and of formation of thromboxanes

, 1980
Aggregationof washed rabbit platelets by thrombin and by carrageenan is accompanied by the activation of phospholipase A2 and by the synthesis of thromboxanes.
F Fouque, B B Vargaftig, M Chignard, C Dumarey   +3 more
core   +1 more source

Effect of fatty acids on leukocyte function

Brazilian Journal of Medical and Biological Research, 2000
Fatty acids have various effects on immune and inflammatory responses, acting as intracellular and intercellular mediators. Polyunsaturated fatty acids (PUFAs) of the omega-3 family have overall suppressive effects, inhibiting lymphocyte proliferation ...
C. Pompéia, L.R. Lopes, C.K. Miyasaka, J. Procópio, P. Sannomiya, R. Curi   +5 more
doaj   +1 more source

Pro-inflammatory and pro-resolving lipid mediators of inflammation in HIV: effect of aspirin interventionResearch in context

EBioMedicine, 2023
Summary: Background: Persons with HIV (PWH) have an increased risk of cardiovascular disease (CVD) compared to HIV-seronegative individuals (SN). Inflammation contributes to this risk but the role of lipid mediators, with central roles in inflammation ...
Jesmond Dalli, Douglas Kitch, Meagan P. O'Brien, Peter W. Hunt, Nicholas Funderburg, Daniela Moisi, Amita Gupta, Todd T. Brown, Phyllis C. Tien, Judith A. Aberg, Rupak Shivakoti   +10 more
doaj   +1 more source