Results 51 to 60 of about 9,969 (239)
, 2013 The design and development of new chemical reactions is crucial to the ongoing success of organic synthesis research. In this work the scope and utility of a recently discovered regioselective palladium-catalysed allylic alkylation (Pd-AA) cascade was ...
Turner, Claire Alison (11694745)
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Frontiers in Immunology, 2020 Asthma represents one of the leading chronic diseases worldwide and causes a high global burden of death and disability. In asthmatic patients, the exacerbation and chronification of the inflammatory response are often related to a failure in the ...
Daniella Bianchi Reis Insuela +5 more
doaj +1 more source
International Journal of Cancer, EarlyView.ABSTRACT Aspirin has been used to treat pain and fever for 120 years. Its uses expanded into treating arthritis and prevention of thrombotic events. Its anti‐cancer role emerged with observational studies in the 1980's and subsequent cancer review in those treated with aspirin in cardiovascular trials.
John Burn, D. Timothy Bishop
wiley +1 more source
Unraveling the Complex Relationship Triad between Lipids, Obesity, and Inflammation
Mediators of Inflammation, 2014 Obesity today stands at the intersection between inflammation and metabolic disorders causing an aberration of immune activity, and resulting in increased risk for diabetes, atherosclerosis, fatty liver, and pulmonary inflammation to name a few ...
Shahida A. Khan +6 more
doaj +1 more source
Neuroprotection, EarlyView.Antiplatelet agents target the cyclooxygenase‐1 (COX‐1)/thromboxane A2 (TXA2) and adenosine diphosphate (ADP)‐P2Y12 (cytochrome P450 2C19 [CYP2C19]‐metabolized) platelet activation pathways, resulting in either drug resistance or over‐inhibition. The individualized therapeutic window balances ischemic risk (triggered by high on‐treatment platelet ...
Guoliang Zhu +7 more
wiley +1 more source
Aspirin alone and combined with a statin suppresses eicosanoid formation in human colon tissue[S]
Journal of Lipid Research, 2018 Eicosanoids, including prostaglandins (PGs) and thromboxanes, are broadly bioactive lipid mediators and increase colon tumorigenesis possibly through chronic inflammatory mechanisms. Epidemiological and experimental data suggest that acetylsalicylic acid
Heike Gottschall +9 more
doaj +1 more source
Biosynthesis of Prostaglandins
, 1977 The conversion of arachidonic acid into PGE2 by homogenates of sheep vesicular glands was demonstrated in 1964 by two groups (1,2). Analogous formation of PGE1 and PGE2 from al1-cis 8,11,14-eicosatri-enoic acid and al1-cis 5,8,11,14,17-eicosapentaenoic ...
Granström, E, Elisabeth Granström
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Bioactive Natural Products in Cardiovascular Disease: Focus on Thrombotic Events
Phytotherapy Research, EarlyView.An overview of the role of natural products (NP) in cardiovascular disease prevention, highlighting key mechanisms of action: including antiplatelet, antithrombotic, anti‐inflammatory, and antioxidant effects. Additionally, it illustrates the integration of diet–drug interactions, nutritional epigenetics, and the role of artificial intelligence in ...
Maria Nektaria Magkoulia +1 more
wiley +1 more source
Insights into the prostanoid pathway in the ovary development of the penaeid shrimp Penaeus monodon. [PDF]
PLoS ONE, 2013 The prostanoid pathway converts polyunsaturated fatty acids (PUFAs) into bioactive lipid mediators, including prostaglandins, thromboxanes and prostacyclins, all of which play vital roles in the immune and reproductive systems in most animal phyla.
Wananit Wimuttisuk +6 more
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, 1977 The major initial steps in the degradation of the prostaglandins are the oxidation of the secondary alcohol group at C-15 and the reduction of the Δ13 double bond (for a recent review, see 1).
Granström, E, Elisabeth Granström
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