Results 71 to 80 of about 9,969 (239)
1. Homogenates of garlic (Allium sativum), onions (Allium cepa) and Allium porum were in vitro incubated with [14C]arachidonic acid. 2. Separation of labelled prostaglandins and thromboxanes were accomplished by thin-layer chromatography (TLC) and the Rf
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, 2006 Almost all mammalian cells produce eicosanoids and their oxidation products, which are synthesized rapidly by cyclooxygenase, lipoxygenase or epoxygenase reactions from arachidonic, homogammalinolenic, eicosapentanoic acids.
Seppänen-Laakso, Tuulikki +2 more
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Structural basis for prostaglandin and drug transport via SLCO2A1
Nature CommunicationsOrganic anion-transporting polypeptide transporters (SLCO/OATPs) function as cellular gatekeepers, regulating intestinal absorption, hepatic and renal clearance, and the tissue distribution of drugs and metabolites in the human body.
Chitra Joshi +10 more
doaj +1 more source
LifeThe arachidonic acid pathway plays a pivotal role in the biosynthesis of important inflammatory and signal transducing agents such as prostaglandins, leukotrienes and thromboxanes.
Filippos Panteleimon Chatzipieris +4 more
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ALOX15 links lipid metabolism to receptor trafficking in platelet activation
The FEBS Journal, EarlyView.This schematic summarizes known and newly identified mechanisms of thrombin‐mediated platelet activation. In addition to classical thrombin‐induced PAR4 signaling pathways, thrombin activates an ALOX15–HETE–PKCθ–NMT1 signaling cascade that promotes protein myristoylation, facilitates receptor trafficking, and enhances PAR4 surface expression on ...
Yosef Eshetie Amare +2 more
wiley +1 more source
Performing Large‐Scale Genetic Analysis in the Bleeding Disorders Community
Haemophilia, EarlyView.ABSTRACT Inherited bleeding disorders encompass a diverse group of conditions caused by genetic defects affecting coagulation factors, fibrinogen, von Willebrand factor, or platelet function. Despite major advances in quantitative and functional laboratory assays, a substantial diagnostic gap remains, particularly in patients with mild or atypical ...
Anna R. Blankstein +6 more
wiley +1 more source
International Journal of Laboratory Hematology, EarlyView.ABSTRACT Bleeding disorder of unknown cause (BDUC) constitutes the largest group of patients presenting with a mild‐to‐moderate bleeding tendency in tertiary care settings. Their clinical bleeding phenotype is characterized by mucocutaneous bleeding, as well as bleeding following surgical challenges or childbirth, and is associated with impaired health‐
Dino Mehic +3 more
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Testing for Non‐Severe Heritable Platelet Function Disorders
International Journal of Laboratory Hematology, EarlyView.ABSTRACT Heritable platelet function disorders (HPFD) are a diverse group of bleeding disorders characterised by a primary qualitative defect in platelet function rather than platelet number. HPFD may be broadly categorised according to the severity of bleeding, with Glanzmann thrombasthenia and Bernard Soulier syndrome classically considered severe ...
Kate Burley +3 more
wiley +1 more source
Platelets and cardiac arrhythmia
Frontiers in Physiology, 2010 Sudden cardiac death remains one of the most prevalent modes of death in industrialized countries, and myocardial ischemia due to thrombotic coronary occlusion is its primary cause.
Jonas S De Jong, Lukas R C Dekker
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Synthetic approaches to thromboxanes [PDF]
, 1980 The more recent developments in the fields of prostaglandin and thromboxane chemistry, and biochemistry, are briefly discussed. The existing syntheses of thromboxane-B2 and analogues of thromboxane-A2 are comprehensively reviewed.
Kelly, Allan Gilmour
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