Results 1 to 10 of about 563,890 (226)

Centrally administered thromboxane A2 analogue facilitates the micturition reflex in rats [PDF]

Scientific Reports
The lower urinary tract stores and periodically eliminates urine, which is regulated by the peripheral and central nervous system (CNS). Thromboxane A₂ (TxA2), an arachidonic acid metabolite known for platelet aggregation, is a neuromodulator exciting ...
Chisato Hamada, Takahiro Shimizu, Mio Togo, Youichirou Higashi, Nobutaka Shimizu, Junichi Furumiya, Motoaki Saito   +6 more
doaj   +2 more sources

Prostanoids in Liver Repair and Regeneration: Biosynthesis, Receptors, and Intercellular CommunicationSummary [PDF]

Cellular and Molecular Gastroenterology and Hepatology
Prostanoids typically refer to prostaglandins, prostacyclin, and thromboxane, and are a series of bioactive lipid mediators primarily derived from arachidonic acid. Prostanoids play pivotal roles in various physiological processes, including liver repair
Xinzhi Li, Xiaobing Xu, Wenjie Lai, Ai Jiang, Na Zhou, Ying Yu   +5 more
doaj   +2 more sources

Physiological Significance of Thromboxane A2 Receptor Dimerization

Journal of Pharmacological Sciences, 2006
.: The thromboxane A2 receptor (TP), one of the G protein-coupled receptors (GPCRs), consists of two splicing variants, TPα and TPβ, which differ in their C-terminal regions.
Masako Sasaki, Katsutoshi Miyosawa, Satoko Ohkubo, Norimichi Nakahata   +3 more
doaj   +4 more sources

SARS-CoV-2 vaccination induced cerebral venous sinus thrombosis: Do megakaryocytes, platelets and lipid mediators make up the orchestra?

Free Neuropathology, 2021
The COVID-19 vaccines comprised of adenoviral vectors encoding the Spike (S) glycoprotein of SARS-CoV-2 are highly effective but associated with rare thrombotic complications.
Kate Chander Chiang, Ravi Raghavan, Ajay Gupta   +2 more
doaj   +1 more source

High-level expression, purification and characterization of a constitutively active thromboxane A2 receptor polymorphic variant. [PDF]

PLoS ONE, 2013
G protein-coupled receptors (GPCRs) exhibit some level of basal signaling even in the absence of a bound agonist. This basal or constitutive signaling can have important pathophysiological roles. In the past few years, a number of high resolution crystal
Bing Xu, Raja Chakraborty, Markus Eilers, Shyamala Dakshinamurti, Joe D O'Neil, Steven O Smith, Rajinder P Bhullar, Prashen Chelikani   +7 more
doaj   +1 more source

Functional enhancement of AT1R potency in the presence of the TPαR is revealed by a comprehensive 7TM receptor co-expression screen. [PDF]

PLoS ONE, 2013
BACKGROUND: Functional cross-talk between seven transmembrane (7TM) receptors can dramatically alter their pharmacological properties, both in vitro and in vivo.
Jonas Tind Hansen, Christina Lyngsø, Tobias Speerschneider, Pernille B L Hansen, Céline Galés, David M Weiner, Søren P Sheikh, Ethan S Burstein, Jakob Lerche Hansen   +8 more
doaj   +1 more source

Dimerization of the Human Receptors for Prostacyclin and Thromboxane Facilitates Thromboxane Receptor-mediated cAMP Generation [PDF]

Journal of Biological Chemistry, 2004
Prostacyclin (PGI(2)) and thromboxane (TxA(2)) are biological opposites; PGI(2), a vasodilator and inhibitor of platelet aggregation, limits the deleterious actions of TxA(2), a vasoconstrictor and platelet activator. The molecular mechanisms involved in the counterregulation of PGI(2)/TxA(2) signaling are unclear.
Stephen J, Wilson, Aoife M, Roche, Ekaterina, Kostetskaia, Emer M, Smyth   +3 more
openaire   +2 more sources

Activation of Nrf2 in Mice Causes Early Microvascular Cyclooxygenase-Dependent Oxidative Stress and Enhanced Contractility

Antioxidants, 2022
Nuclear factor erythroid factor E2-related factor 2 (Nrf2) transcribes antioxidant genes that reduce the blood pressure (BP), yet its activation with tert-butylhydroquinone (tBHQ) in mice infused with angiotensin II (Ang II) increased mean arterial ...
Dan Wang, Cheng Wang, Xueqin Hao, Gabriela Carter, Rafaela Carter, William J. Welch, Christopher S. Wilcox   +6 more
doaj   +1 more source

ANTITHROMBOTIC THERAPY OF ISCHEMIC HEART DISEASE: FROM FAST ACTING ANTIAGGREGANTS TO STATINES AND NITRATE OXIDE. IS IT REAL?

Рациональная фармакотерапия в кардиологии, 2016
Mechanisms of atherothrombosis in atherosclerosis of coronary arteries are described. Mechanism of action and clinical efficiency of antithrombotic and antiplatelet medicines such as acetylsalicylic acid, warfarin, ticlopidine and clopidogrel are ...
I. A. Latfullin, A. A. Podolskaya
doaj   +1 more source

Thromboxanes: Synthase and Receptors

Journal of Biomedical Science, 1998
Thromboxane A2 is a biologically potent arachidonate metabolite through the cyclooxygenase pathway. It induces platelet aggregation and smooth muscle contraction and may promote mitogenesis and apoptosis of other cells. Its roles in physiological and pathological conditions have been widely documented.
R F, Shen, H H, Tai
openaire   +2 more sources