Results 11 to 20 of about 563,890 (226)
Thromboxane Receptors Antagonists and/or Synthase Inhibitors
Journal of Synthetic Organic Chemistry, Japan, 2012 Atherothrombosis is the major cause of mortality and morbidity in Western countries. Several clinical conditions are characterized by increased incidence of cardiovascular events and enhanced thromboxane (TX)-dependent platelet activation. Enhanced TX generation may be explained by mechanisms relatively insensitive to aspirin.
Giovanni, Davì +2 more
core +5 more sources
Current status and future perspectives of platelet function-guided precision antiplatelet therapy for patients with cerebral infarction. [PDF]
NeuroprotectionAntiplatelet agents target the cyclooxygenase‐1 (COX‐1)/thromboxane A2 (TXA2) and adenosine diphosphate (ADP)‐P2Y12 (cytochrome P450 2C19 [CYP2C19]‐metabolized) platelet activation pathways, resulting in either drug resistance or over‐inhibition. The individualized therapeutic window balances ischemic risk (triggered by high on‐treatment platelet ...
Zhu G +7 more
europepmc +2 more sources
, 1993 Signal transduction mechanisms associated with human platelet thromboxane A(2)/prostaglandin H(2 ...
Irina. Knezevic (7964099)
core +6 more sources
, 2010 Thromboxane A2 and thrombin receptors mediate platelet activation through P2Y12-independent ...
Subhashini. Srinivasan (7976252)
core +6 more sources
Contemporary management of pain in cirrhosis: Toward precision therapy for pain
Hepatology, EarlyView., 2022 Abstract Chronic pain is highly prevalent in patients with cirrhosis and is associated with poor health‐related quality of life and poor functional status. However, there is limited guidance on appropriate pain management in this population, and pharmacologic treatment can be harmful, leading to adverse outcomes, such as gastrointestinal bleeding ...
Alexis Holman +4 more
wiley +1 more source
Hepatology, EarlyView., 2022 Increased liver content of DHA‐derived small lipid autacoids (i.e resolvin D1 and maresin 1) associates with enhanced mitochondrial oxidative phosphorylation, fatty acid β‐oxidation and bioenergetic metabolic flux. These features provide hepatic protection from steatotic, pro‐inflammatory and fibrogenic insults.
Cristina López‐Vicario +12 more
wiley +1 more source
, 2005 Identification and characterization of thromboxane A2 receptors in oligodendrocytes and Schwann ...
Samuel C. Blackman (7975766)
core +6 more sources
Antagonism of thromboxane receptors by diclofenac and lumiracoxib [PDF]
British Journal of Pharmacology, 2007 British Journal of Pharmacology (2008) 153, 1763; doi:10.1038/bjp.2008 ...
E, Selg +14 more
openaire +4 more sources
Thromboxane and the thromboxane receptor in cardiovascular disease [PDF]
Clinical Lipidology, 2010 Thromboxane A(2) (TXA(2)), the primary product of COX-1-dependent metabolism of arachidonic acid, mediates its biological actions through the TXA(2) receptor, termed the TP. Irreversible inhibition of platelet COX-1-derived TXA(2) with low-dose aspirin affords protection against primary and secondary vascular thrombotic events, underscoring the central
openaire +2 more sources
Kinin-B1 receptors in ischaemia-induced pancreatitis: Functional importance and cellular localisation [PDF]
, 2003 In this study we compare the role of kininB1 and B2 receptors during ischaemia/reperfusion of rat pancreas. Our investigations were prompted by the observation that infusion of a kininB2 receptor antagonist produced significant improvement in acute ...
A. A. Roscher +11 more
core +1 more source