Results 31 to 40 of about 563,890 (226)
Biomedicines, 2022 Liposomal amphotericin B (Abelcet) can cause infusion (anaphylactoid) reactions in patients whose mechanism is poorly understood. Here, we used mice to investigate the role of complement (C) receptors and the cellular sources of vasoactive mediators in ...
Erik Őrfi +6 more
doaj +1 more source
Expression of thromboxane synthase and the thromboxane-prostanoid receptor in the mouse and rat retina [PDF]
Experimental Eye Research, 2009 Experimental models of the diabetic retina have suggested a pathological role for thromboxane. To date however, little information is available as to the cellular locations of retinal thromboxane synthase (TxS), or its receptor, even in non-diabetic controls.
William S, Wright +2 more
openaire +2 more sources
Antiplatelet Effect of NQ12: a Possible Mechanism Through the Arachidonic Acid Cascade
Journal of Pharmacological Sciences, 2007 NQ12, an antithrombotic agent, has been reported to display a potent antiplatelet activity. This study was undertaken to reveal the effect of NQ12 on rabbit platelet aggregation and signal transduction involved in the arachidonic acid (AA) cascade.
Yong-Ri Jin +8 more
doaj +1 more source
NEW ANTIPLATELET DRUGS (PART 1)
Рациональная фармакотерапия в кардиологии, 2016 Antiplatelet agents are a necessary component of modern atherosclerosis therapy. The difficulties of antiplatelet treatment lie in the balance between the necessary therapeutic effect of the drug and the risk of excessive action leading to the bleeding ...
A. B. Sumarokov
doaj +3 more sources
Activation of thromboxane A2 receptors mediates endothelial dysfunction in diabetic mice
Clinical and Experimental Hypertension, 2017 Background: Diabetes is one of high-risk factors for cardiovascular disease. Improvement of endothelial dysfunction in diabetes reduces vascular complications. However, the underlying mechanism needs to be uncovered. This study was conducted to elucidate
Xiaona Xie +5 more
doaj +1 more source
Allergology International, 2015 Prostanoids, which include prostaglandin and thromboxane, are metabolites of arachidonic acid released in various pathophysiological conditions. They induce a range of actions mediated through their respective receptors expressed on target cells.
Tetsuya Honda, Kenji Kabashima
doaj +1 more source
Biomolecules, 2021 Nucleotides released by smooth muscle cells (SMCs) and by innervating nerve terminals activate specific P2 receptors and modulate bladder contraction. We hypothesized that cell surface enzymes regulate SMC contraction in mice bladder by controlling the ...
Romuald Brice Babou Kammoe +4 more
doaj +1 more source
Physiological Reports, 2021 Mechanical and metabolic signals associated with skeletal muscle contraction stimulate the sensory endings of thin fiber muscle afferents and produce reflex increases in sympathetic nerve activity and blood pressure during exercise (i.e., the exercise ...
Alec L. E. Butenas +8 more
doaj +1 more source
iScienceSummary: Thromboxane prostanoid (TP) receptors play an important role in platelet activation and hemostasis. Although TP receptors undergo palmitoylation within the platelet proteome, its impact on platelet functions and the underlying mechanisms have ...
Suresh Govatati +3 more
doaj +1 more source
NEW ANTIPLATELET DRUGS. PART 2
Рациональная фармакотерапия в кардиологии, 2016 Antiplatelet agents are a necessary component of modern therapy of atherosclerosis. The difficulties of the antiplatelet treatment lie in balance between the necessary therapeutic effect and the risk of excessive action, leads to the bleeding.
A. B. Sumarokov
doaj +1 more source