Results 1 to 10 of about 113,969,313 (213)

Thromboxane A synthase-independent production of 12-hydroxyheptadecatrienoic acid, a BLT2 ligand[S] [PDF]

Journal of Lipid Research, 2013
12(S)-hydroxyheptadeca-5Z,8E,10E-trienoic acid (12-HHT) has long been considered a by-product of thromboxane A2 (TxA2) biosynthesis with no biological activity.
Takehiko Matsunobu, Toshiaki Okuno, Chieko Yokoyama, Takehiko Yokomizo   +3 more
doaj   +2 more sources

Current status and future perspectives of platelet function-guided precision antiplatelet therapy for patients with cerebral infarction. [PDF]

Neuroprotection
Antiplatelet agents target the cyclooxygenase‐1 (COX‐1)/thromboxane A2 (TXA2) and adenosine diphosphate (ADP)‐P2Y12 (cytochrome P450 2C19 [CYP2C19]‐metabolized) platelet activation pathways, resulting in either drug resistance or over‐inhibition. The individualized therapeutic window balances ischemic risk (triggered by high on‐treatment platelet ...
Zhu G, Chen X, Huang X, Tan Q, Cao Q, Yang Y, Lin Y, Yang J.   +7 more
europepmc   +2 more sources

VEGF inhibitor-induced vascular dysfunction involves redox-sensitive PARP activation and SIRT1 disruption. [PDF]

Exp Physiol
Abstract Vascular endothelial growth factor receptor (VEGFR) inhibitors are effective antiangiogenic agents used in cancer therapy. However, they are associated with cardiovascular disease, including hypertension and vascular dysfunction. The molecular mechanisms underlying these cardiovascular toxicities are unclear, but oxidative stress might be ...
Neves KB, Alves-Lopes R, Montezano AC, Touyz RM.   +3 more
europepmc   +2 more sources

Ozagrel hydrochloride, a selective thromboxane A₂ synthase inhibitor, alleviates liver injury induced by acetaminophen overdose in mice [PDF]

BMC Gastroenterology, 2013
Background Overdosed acetaminophen (paracetamol, N-acetyl-p-aminophenol; APAP) causes severe liver injury. We examined the effects of ozagrel, a selective thromboxane A2 (TXA2) synthase inhibitor, on liver injury induced by APAP overdose in mice. Methods
Tomishima Yoshiro, Ishitsuka Yoichi, Matsunaga Naoya, Nagatome Minako, Furusho Hirokazu, Irikura Mitsuru, Ohdo Shigehiro, Irie Tetsumi   +7 more
doaj   +2 more sources

Lung-Cardiovascular Interactions and Derangements in ARDS. [PDF]

Compr Physiol
This review proposes an anatomical near‐ and far‐field framework for lung‐cardiovascular interactions in ARDS. Grounded in pathological and biological studies, the evidence spans pulmonary vascular, right ventricular, and systemic endothelial derangements and reviews available evidence for targeted therapies.
Sanchez PA, O'Brien C, Legrand M, Calfee CS, Matthay MA.   +4 more
europepmc   +2 more sources

The Role and Regulation of Thromboxane A₂ Signaling in Cancer-Trojan Horses and Misdirection

Molecules, 2022
Over the last two decades, there has been an increasing awareness of the role of eicosanoids in the development and progression of several types of cancer, including breast, prostate, lung, and colorectal cancers.
Anthony W. Ashton, Yunjia Zhang, Rosanna Cazzolli, Kenneth V. Honn   +3 more
doaj   +1 more source

Essential lipid autacoids rewire mitochondrial energy efficiency in metabolic dysfunction‐associated fatty liver disease

Hepatology, EarlyView., 2022
Increased liver content of DHA‐derived small lipid autacoids (i.e resolvin D1 and maresin 1) associates with enhanced mitochondrial oxidative phosphorylation, fatty acid β‐oxidation and bioenergetic metabolic flux. These features provide hepatic protection from steatotic, pro‐inflammatory and fibrogenic insults.
Cristina López‐Vicario, David Sebastián, Mireia Casulleras, Marta Duran‐Güell, Roger Flores‐Costa, Ferran Aguilar, Juan José Lozano, Ingrid W. Zhang, Esther Titos, Jing X. Kang, Antonio Zorzano, Makoto Arita, Joan Clària   +12 more
wiley   +1 more source

High-Intensity Exercise Training Improves Basal Platelet Prostacyclin Sensitivity and Potentiates the Response to Dual Anti-Platelet Therapy in Postmenopausal Women

Biomolecules, 2022
The risk of thrombotic events dramatically increases with age and may be accelerated in women by the cessation of endogenous estrogen production at menopause.
Kate A. Wickham, Line B. Nørregaard, Martina H. Lundberg Slingsby, Stephen S. Cheung, Ylva Hellsten   +4 more
doaj   +1 more source

Activation of thromboxane A2 receptor (TP) increases the expression of monocyte chemoattractant protein -1 (MCP-1)/chemokine (C-C motif) ligand 2 (CCL2) and recruits macrophages to promote invasion of lung cancer cells. [PDF]

PLoS ONE, 2013
Thromboxane synthase (TXAS) and thromboxane A(2) receptor (TP), two critical components for thromboxane A(2) (TXA(2)) signaling, have been suggested to be involved in cancer invasion and metastasis.
Xiuling Li, Hsin-Hsiung Tai
doaj   +1 more source

Activation of Nrf2 in Mice Causes Early Microvascular Cyclooxygenase-Dependent Oxidative Stress and Enhanced Contractility

Antioxidants, 2022
Nuclear factor erythroid factor E2-related factor 2 (Nrf2) transcribes antioxidant genes that reduce the blood pressure (BP), yet its activation with tert-butylhydroquinone (tBHQ) in mice infused with angiotensin II (Ang II) increased mean arterial ...
Dan Wang, Cheng Wang, Xueqin Hao, Gabriela Carter, Rafaela Carter, William J. Welch, Christopher S. Wilcox   +6 more
doaj   +1 more source