Journal of Pharmacological Sciences, 2009 This study examined the effect of ozagrel, a thromboxane A2 synthase inhibitor, on the accumulation of leucocytes and chemokine mRNA expression in lungs experimentally injured using oleic acid (OA).
Yoichi Ishitsuka +8 more
doaj +1 more source
Trypanosoma cruzi infection and endothelin-1 cooperatively activate pathogenic inflammatory pathways in cardiomyocytes. [PDF]
PLoS Neglected Tropical Diseases, 2013 Trypanosoma cruzi, the causative agent of Chagas' disease, induces multiple responses in the heart, a critical organ of infection and pathology in the host.
Ricardo S Corral +4 more
doaj +1 more source
Modification of platelet proteins by malondialdehyde: prevention by dicarbonyl scavengers[S]
Journal of Lipid Research, 2015 The thromboxane synthase converts prostaglandin H2 to thromboxane A2 and malondialdehyde (MDA) in approximately equimolar amounts. A reactive dicarbonyl, MDA forms covalent adducts of amino groups, including the ε-amine of lysine, but the importance of ...
Irene Zagol-Ikapite +8 more
doaj +1 more source
Expression of thromboxane synthase and the thromboxane-prostanoid receptor in the mouse and rat retina [PDF]
Experimental Eye Research, 2009 Experimental models of the diabetic retina have suggested a pathological role for thromboxane. To date however, little information is available as to the cellular locations of retinal thromboxane synthase (TxS), or its receptor, even in non-diabetic controls.
William S, Wright +2 more
openaire +2 more sources
Antiplatelet Effect of NQ12: a Possible Mechanism Through the Arachidonic Acid Cascade
Journal of Pharmacological Sciences, 2007 NQ12, an antithrombotic agent, has been reported to display a potent antiplatelet activity. This study was undertaken to reveal the effect of NQ12 on rabbit platelet aggregation and signal transduction involved in the arachidonic acid (AA) cascade.
Yong-Ri Jin +8 more
doaj +1 more source
Expression of human thromboxane synthase using a baculovirus system [PDF]
, 1993 Human thromboxane (TX) synthase (EC 5.3.99.5) was produced by the baculovirus expression system using cDNA encoding human TX synthase [(1991) Biochem. Biophys. Res. Commun. 78, 1479-1484].
Tanabe, Tadashi +17 more
core +1 more source
Anti-thromboxane B2 antibodies protect against acetaminophen-induced liver injury in mice
Journal of Xenobiotics, 2011 Prostanoids are lipid compounds that mediate a variety of physiological and pathological functions in almost all body tissues and organs. Thromboxane (TX) A2 is a powerful inducer of platelet aggregation and vasoconstriction and it has ulcerogenic ...
Ivan Ćavar +3 more
doaj +1 more source
Cells, 2022 Withanolide A is a naturally occurring phytochemical that is found in Ashwagandha (Withania somnifera, fam. Solanaceae) or Indian Ginseng. In the current study, we elucidated the effect of withanolide A on 7-ketocholesterol (7KC) induced injury in hCMEC ...
Sandra Soh, Wei-Yi Ong
doaj +1 more source
Cellular Physiology and Biochemistry, 2016 Background/Aims: ICCs are the pacemaker cells responsible for slow waves in gastrointestinal (GI) smooth muscle, and generate periodic pacemaker potentials in current-clamp mode.
Hyun Jung Kim +5 more
doaj +1 more source
Endogenous Prostaglandin Endoperoxides P May Alter Infarct Size In The Presence Of Thromboxane Synthase Inhibition: Studies In A Rabbit Model Of Coronary Artery Occlusion-Reperfusion [PDF]
, 1993 OBJECTIVES: The aim of this study was to assess whether prostaglandin endoperoxides, which continue to be formed in the setting of thromboxane A2 synthase inhibition, might influence the fate of ischemic myocardium in a model of coronary occlusion and ...
F. De Clerk +16 more
core +1 more source