Results 11 to 20 of about 113,969,313 (213)

Examination of thromboxane synthase as a prognostic factor and therapeutic target in non-small cell lung cancer [PDF]

Molecular Cancer, 2011
Background Thromboxane synthase (TXS) metabolises prostaglandin H2 into thromboxanes, which are biologically active on cancer cells. TXS over-expression has been reported in a range of cancers, and associated with a poor prognosis. TXS inhibition induces
O'Byrne Kenneth J, Kay Elaine, Cummins Robert, Gately Kathy, Cathcart Mary-Clare, Pidgeon Graham P   +5 more
doaj   +3 more sources

Thromboxane synthase inhibitors and receptor antagonists

Cardiovascular Drugs and Therapy, 1992
Platelet activation plays a major role in myocardial infarction and in reocclusion following successful thrombolysis, as corroborated by several clinical studies using aspirin. However, the overall reduction of new vascular complications in patients with symptomatic arterial disease by aspirin was only around 25%.
J, Vermylen, H, Deckmyn
openaire   +3 more sources

Thromboxane Receptors Antagonists and/or Synthase Inhibitors

Journal of Medicinal Chemistry, 2012
Atherothrombosis is the major cause of mortality and morbidity in Western countries. Several clinical conditions are characterized by increased incidence of cardiovascular events and enhanced thromboxane (TX)-dependent platelet activation. Enhanced TX generation may be explained by mechanisms relatively insensitive to aspirin.
Giovanni, Davì, Francesca, Santilli, Natale, Vazzana   +2 more
core   +6 more sources

Terbogrel, a dual-acting agent for thromboxane receptor antagonism and thromboxane synthase inhibition

Acta Crystallographica Section C Crystal Structure Communications, 2000
Terbogrel, (E)-6-[4-(3-tert-butyl-2-cyanoguanidino)phenyl]-6-(3-pyridyl)hex-5 -enoic acid, C(23)H(27)N(5)O(2), a mixed thromboxane A(2) receptor antagonist and thromboxane A(2) synthase inhibitor, shows a hairpin-like conformation stabilized by an intramolecular hydrogen bond.
Michaux, Catherine, Norberg, Bernadette, Dogné, Jean-Michel, Durant, François, Masereel, Bernard, Delarge, Jacques, Wouters, Johan   +6 more
openaire   +4 more sources

Pharmacology of the Thromboxane Receptor Antagonist and Thromboxane Synthase Inhibitor BM‐531 [PDF]

Cardiovascular Drug Reviews, 2001
ABSTRACTBM‐531 (N‐tert‐butyl‐N'‐[(2‐cyclohexylamino‐5‐nitrobenzene)sulfonyl]urea), a torasemide derivative, is a novel noncarboxylic thromboxane receptor antagonist and thromboxane synthase inhibitor. Indeed, its affinity for human washed platelet TXA2receptors labeled with [3H]SQ‐29548 (IC50= 0.0078 μM) is higher than sulotroban (IC50= 0.93 μM) and SQ‐
J M, Dogné, S, Rolin, X, de Leval, P, Benoit, P, Neven, J, Delarge, P, Kolh, J, Damas, J L, David, B, Masereel   +9 more
openaire   +4 more sources

Insights into the prostanoid pathway in the ovary development of the penaeid shrimp Penaeus monodon. [PDF]

PLoS ONE, 2013
The prostanoid pathway converts polyunsaturated fatty acids (PUFAs) into bioactive lipid mediators, including prostaglandins, thromboxanes and prostacyclins, all of which play vital roles in the immune and reproductive systems in most animal phyla.
Wananit Wimuttisuk, Punsa Tobwor, Pacharawan Deenarn, Kannawat Danwisetkanjana, Decha Pinkaew, Kanyawim Kirtikara, Vanicha Vichai   +6 more
doaj   +1 more source

Inhibitors of thromboxane synthase in human platelets [PDF]

FEBS Letters, 1977
Thromboxanes A are a new group of compounds with extreme potency to induce platelet aggregation and smooth muscle contractions. They are derived from prostaglandin endoperoxides and have a half-life of only 30-~40 s in aqueous solution (pH 7.4, 37°C). Thromboxanes B, the products of the spontaneous degradation, are biologically inactive [ 1 ] .
Diczfalusy, Ulf, Hammarström, Sven
openaire   +2 more sources

Increased Levels of Txa2 Induced by Dengue Virus Infection in IgM Positive Individuals Is Related to the Mild Symptoms of Dengue

Viruses, 2018
The inflammatory process plays a major role in the prognosis of dengue. In this context, the eicosanoids may have considerable influence on the regulation of the Dengue virus-induced inflammatory process.
Eneida S. Oliveira, Stella G. Colombarolli, Camila S. Nascimento, Izabella C. A. Batista, Jorge G. G. Ferreira, Daniele L. R. Alvarenga, Laís O. B. de Sousa, Rafael R. Assis, Marcele N. Rocha, Érica A. R. Alves, Carlos E. Calzavara-Silva   +10 more
doaj   +1 more source

Thromboxanes: Synthase and Receptors

Journal of Biomedical Science, 1998
Thromboxane A2 is a biologically potent arachidonate metabolite through the cyclooxygenase pathway. It induces platelet aggregation and smooth muscle contraction and may promote mitogenesis and apoptosis of other cells. Its roles in physiological and pathological conditions have been widely documented.
R F, Shen, H H, Tai
openaire   +2 more sources

Thromboxane Mobilizes Insect Blood Cells to Infection Foci

Frontiers in Immunology, 2021
Innate immune responses are effective for insect survival to defend against entomopathogens including a fungal pathogen, Metarhizium rileyi, that infects a lepidopteran Spodoptera exigua.
Miltan Chandra Roy, Kiwoong Nam, Jaesu Kim, David Stanley, Yonggyun Kim   +4 more
doaj   +1 more source