Results 31 to 40 of about 113,969,313 (213)

Effects of thromboxane synthase inhibition with CGS 13080 in human cyclosporine nephrotoxicity [PDF]

, 1992
Effects of thromboxane synthase inhibition with CGS 13080 in human cyclosporine nephrotoxicity. Cyclosporine is a potent immunosuppressive agent, however, its use is limited by nephrotoxicity.
Rakhit, Ashok, Louis L. Martin, Elizabeth A. Creech, Paul E. Klotman, Creech, Elizabeth A., Frank L. Douglas, Klotman, Paul E., Smith, Stephen R., Coffman, Thomas M., Martin, Louis L., Ashok Rakhit, Thomas M. Coffman, A. Victoria Schaffer, Schaffer, A. Victoria, Douglas, Frank L., Stephen R. Smith   +15 more
core   +1 more source

New analogues of 13-hydroxyocatdecadienoic acid and 12-hydroxyeicosatetraenoic acid block human blood platelet aggregation and cyclooxygenase-1 activity

Chemistry Central Journal, 2012
Background Thromboxane A2 is derived from arachidonic acid through the action of cyclooxygenases and thromboxane synthase. It is mainly formed in blood platelets upon activation and plays an important role in aggregation. Aspirin is effective in reducing
Hirz Taghreed, Khalaf Ali, El-Hachem Nehme, Mrad May F, Abdallah Hassan, Créminon Christophe, Grée René, Merhi Raghida Abou, Habib Aïda, Hachem Ali, Hamade Eva   +10 more
doaj   +1 more source

Hepatic Encephalopathy-Associated Cerebral Vasculopathy in Acute-on-Chronic Liver Failure: Alterations on Endothelial Factor Release and Influence on Cerebrovascular Function

Frontiers in Physiology, 2020
The acute-on-chronic liver failure (ACLF) is a syndrome characterized by liver decompensation, hepatic encephalopathy (HE) and high mortality. We aimed to determine the mechanisms implicated in the development of HE-associated cerebral vasculopathy in a ...
Laura Caracuel, Laura Caracuel, Esther Sastre, Esther Sastre, María Callejo, Raquel Rodrigues-Díez, Raquel Rodrigues-Díez, Raquel Rodrigues-Díez, Ana B. García-Redondo, Ana B. García-Redondo, Ana B. García-Redondo, Isabel Prieto, Isabel Prieto, Carlos Nieto, Mercedes Salaices, Mercedes Salaices, Mercedes Salaices, Ma Ángeles Aller, Jaime Arias, Javier Blanco-Rivero, Javier Blanco-Rivero, Javier Blanco-Rivero   +21 more
doaj   +1 more source

Arterial thromboxane A2-induced transient contraction after IL-1β exposure

European Journal of Inflammation, 2022
The involvement of thromboxane A2 (TXA2) in systemic inflammation and infection is well recognized. However, there are few reports on the involvement of prostanoids in warm shock (the initial pathology of sepsis). Previous studies showed that interleukin
Katsuya Yuui, Risa Kudo, Shogo Kasuda
doaj   +1 more source

Inhibitory effects of thromboxane A2 generation by ginsenoside Ro due to attenuation of cytosolic phospholipase A2 phosphorylation and arachidonic acid release

Journal of Ginseng Research, 2019
Background: Thromboxane A2 (TXA2) induces platelet aggregation and promotes thrombus formation. Although ginsenoside Ro (G-Ro) from Panax ginseng is known to exhibit a Ca2+-antagonistic antiplatelet effect, whether it inhibits Ca2+-dependent cytosolic ...
Jung-Hae Shin, Hyuk-Woo Kwon, Man Hee Rhee, Hwa-Jin Park   +3 more
doaj   +1 more source

The biochemical pharmacology of thromboxane synthase inhibition in man.

, 1985
Selective inhibitors of thromboxane synthase have two theoretical advantages over inhibitors of the cyclooxygenase enzyme as potential antithrombotic compounds.
A K Pedersen, I A Reilly, G A FitzGerald
core   +1 more source

Antihypertensive treatment differentially affects vascular sphingolipid biology in spontaneously hypertensive rats. [PDF]

PLoS ONE, 2011
We have previously shown that essential hypertension in humans and spontaneously hypertensive rats (SHR), is associated with increased levels of ceramide and marked alterations in sphingolipid biology.
Léon J A Spijkers, Ben J A Janssen, Jelly Nelissen, Merlijn J P M T Meens, Dayanjan Wijesinghe, Charles E Chalfant, Jo G R De Mey, Astrid E Alewijnse, Stephan L M Peters   +8 more
doaj   +1 more source

Effects of BM-573 on Endothelial Dependent Relaxation and Increased Blood Pressure at Early Stages of Atherosclerosis. [PDF]

PLoS ONE, 2016
Endothelial dysfunction is considered to be an early event in atherosclerosis and plays a pivotal role in the development, progression and clinical complications of atherosclerosis.
Miguel Romero, Elvira Leon-Gomez, Irina Lobysheva, Géraldine Rath, Jean-Michel Dogné, Olivier Feron, Chantal Dessy   +6 more
doaj   +1 more source

Increased thromboxane biosynthesis in a human preparation of platelet activation: biochemical and functional consequences of selective inhibition of thromboxane synthase.

, 1986
Although thromboxane A2 is a potent platelet agonist and vasoconstrictor in vitro, our knowledge of its pathophysiologic importance in human disease is limited.
J B Doran, I A Reilly, B Smith, G A FitzGerald   +3 more
core   +1 more source

Stability of thromboxane in blood samples. [PDF]

, 2019
To access publisher's full text version of this article, please click on the hyperlink in Additional Links field or click on the hyperlink at the top of the page marked DownloadIntroduction: Conventional venous blood collection requires a puncture with a
Ólafsson, Ísleifur, Andersen, Karl, Andersen, Karl Konráð, Ólafsson, Ísleifur Hákon, Helgadóttir, Helga, Gizurarson, Sveinbjörn   +5 more
core   +1 more source