Results 41 to 50 of about 113,969,313 (213)

Mechanisms Responsible for Serotonin Vascular Reactivity Sex Differences in the Internal Mammary Artery

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2018
Background The increased adverse cardiac events in women undergoing coronary artery bypass grafting are multifactorial and may include clinical, psychosocial, and biological factors.
Victor Lamin, Amenah Jaghoori, Rachel Jakobczak, Irene Stafford, Tamila Heresztyn, Michael Worthington, James Edwards, Fabiano Viana, Robert Stuklis, David P. Wilson, John F. Beltrame   +10 more
doaj   +1 more source

Endothelotropic activity of 4-hydroxy-3,5-di-tret-butylcinnamic acid in the conditions of experimental cerebral ischemia [PDF]

Research Results in Pharmacology, 2018
Introduction: The aim of the study was to evaluate the endothelioprotective activity of 4-hydroxy-3,5-di-tret-butylcinnamic acid in conditions of experimental cerebral ischemia.
Andrey V. Voronkov, Dmitrij I. Pozdnyakov   +1 more
doaj   +3 more sources

Commonalities of platelet dysfunction in heart failure with preserved ejection fraction and underlying comorbidities

ESC Heart Failure, Volume 12, Issue 2, Page 1013-1028, April 2025.
Abstract Heart failure with preserved ejection fraction (HFpEF) is characterized by a lack of a specific targeted treatment and a complex, partially unexplored pathophysiology. Common comorbidities associated with HFpEF are hypertension, atrial fibrillation, obesity and diabetes.
Giorgia D'Italia, Blanche Schroen, Judith M.E.M. Cosemans   +2 more
wiley   +1 more source

3-[5-(1H-Indol-3-ylmethylene)-4-oxo-2-thioxothiazolidin-3-yl]-propionic Acid as a Potential Polypharmacological Agent

Scientia Pharmaceutica, 2023
Searching for new types of biological activities among preliminarily identified hit compounds is a key challenge in modern medicinal chemistry. In our study, a previously studied 3-[5-(1H-indol-3-ylmethylene)-4-oxo-2-thioxothiazolidin-3-yl]-propionic ...
Yulian Konechnyi, Andrii Lozynskyi, Iryna Ivasechko, Tetiana Dumych, Solomiya Paryzhak, Oksana Hrushka, Ulyana Partyka, Iryna Pasichnyuk, Dmytro Khylyuk, Roman Lesyk   +9 more
doaj   +1 more source

Thromboxane synthase immunohistochemistry in inflammatory bowel disease [PDF]

Journal of Clinical Pathology, 2002
Thromboxanes are produced in excess in inflammatory bowel disease. Preliminary reports suggest that ridogrel, a thromboxane synthase inhibitor, is anti-inflammatory and may have therapeutic benefits in patients with ulcerative colitis.To investigate the immunohistochemical expression of thromboxane synthase in the colorectal mucosa of patients with ...
E, Carty, C, Nickols, R M, Feakins, D S, Rampton   +3 more
openaire   +2 more sources

Role of plasma neuropeptide Y in acute myocardial infarction: a case-control study

BMC Cardiovascular Disorders
Background As neuropeptide Y is associated with endothelial dysfunction, this study explored the relationship between neuropeptide Y and acute myocardial infarction. Methods We included 128 acute myocardial infarction cases and 62 controls.
Yan-li Zheng, Hui-li Lin, Yue-ting Li, Mei-mei Li, Jing-ru Du, Wan-da Wang, Yao-guo Wang, Yin-lian Cai   +7 more
doaj   +1 more source

The Microbiome as a Mirror: Distinguishing Healthy Individuals From Chronic Constipated Patients and Identifying Those With Hidden Psychiatric Burden

Microbiota Medicine Research, EarlyView.
Gut microbiota signatures distinguish chronic constipated patients from healthy individuals, supporting noninvasive diagnostic potential. Despite challenges in identifying psychiatric‐related comorbidities, microbial alterations, particularly in neurotransmitter and inflammatory pathways, lay the groundwork for future companion diagnostics and ...
Hongyan Qi, Ting Yu, Weichen Liu, Ya Jiang, Die Chen, Li Gao, Hui Li, Yurong Tang   +7 more
wiley   +1 more source

Regulation of cyclooxygenase and thromboxane synthase in human monocytes [PDF]

European Journal of Biochemistry, 1992
Stimulation of human monocytes by lipopolysaccharide or phorbol ester resulted in an increase in thromboxane‐B2 and prostaglandin‐E2 production, wherease interleukin1, tumour necrosis factor α and leukotriene C4 exerted no effects. Inhibitors of protein kinase C suppressed these increases.
R, Nüsing, V, Ullrich
openaire   +2 more sources

Thromboxane Modulating Agents. 3. 1H-Imidazol-1-ylalkyl- and 3-Pyridinylalkyl-Substituted 3-[2-[(Arylsulfonyl)amino]ethyl]benzenepropanoic Acid Derivatives as Dual Thromboxane Synthase Inhibitor/Thromboxane Receptor Antagonists

, 2016
The design of a series of dual thromboxane synthase inhibitor/thromboxane receptor antagonists based on a 3-[2-[(arylsulfonyl)amino]ethyl]benzenepropanoic acid thromboxane receptor antagonist template is described.
Clive J. Long (3020463), Kevin N. Dack (1309485), Roger P. Dickinson (2491471), John Steele (341456)   +3 more
core   +1 more source

Imbalanced prostanoid release mediates cigarette smoke-induced human pulmonary artery cell proliferation

Respiratory Research, 2022
Background Pulmonary hypertension is a common and serious complication of chronic obstructive pulmonary disease (COPD). Studies suggest that cigarette smoke can initiate pulmonary vascular remodelling by stimulating cell proliferation; however, the ...
Abdullah A. Alqarni, Oliver J. Brand, Alice Pasini, Mushabbab Alahmari, Abdulrhman Alghamdi, Linhua Pang   +5 more
doaj   +1 more source