Results 61 to 70 of about 113,969,313 (213)

Inflammatory and Immunological Basis of Periodontal Diseases

Journal of Periodontal Research, EarlyView.
The periodontal lesion emerges as an evolving immunological battlefield, where host–microbiome interactions, dysregulated immune responses, fragile resolution mechanisms, and inflammophilic dysbiosis converge to shift the balance from homeostasis to unrestrained tissue destruction.
Giacomo Baima, Marion Arce, Mario Romandini, Thomas Van Dyke   +3 more
wiley   +1 more source

Oxidative Stress-Dependent Coronary Endothelial Dysfunction in Obese Mice. [PDF]

PLoS ONE, 2015
Obesity is involved in several cardiovascular diseases including coronary artery disease and endothelial dysfunction. Endothelial Endothelium vasodilator and vasoconstrictor agonists play a key role in regulation of vascular tone.
Ana María Gamez-Mendez, Hilda Vargas-Robles, Amelia Ríos, Bruno Escalante   +3 more
doaj   +1 more source

R68070, a combined thromboxane/endoperoxide receptor antagonist and thromboxane synthase inhibitor, inhibits human platelet activation in vitro and in vivo: a comparison with aspirin

, 1990
We have investigated the effects of R68070 on platelet function in vitro and in vivo. The drug inhibits U46619-induced aggregation (IC50 = 1.2 x 10(-6) mol/L), blocks serum thromboxane formation (IC50 = 1 x 10(-7) mol/L), and increases serum ...
Vermylen, Jozef, Arnout, Jozef, Falcon, C., De Reys, S., Deckmyn, Hans, Hoet, B.   +5 more
core   +1 more source

Activation of thromboxane A2 receptors mediates endothelial dysfunction in diabetic mice

Clinical and Experimental Hypertension, 2017
Background: Diabetes is one of high-risk factors for cardiovascular disease. Improvement of endothelial dysfunction in diabetes reduces vascular complications. However, the underlying mechanism needs to be uncovered. This study was conducted to elucidate
Xiaona Xie, Wanchun Sun, Jun Wang, Xiaoou Li, Xiaofeng Liu, Ning Liu   +5 more
doaj   +1 more source

TMEM16A channel signalling microdomains in the regulation of vascular function

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic representation of TMEM16A channel signalling microdomains. Calcium influx or calcium release from the endoplasmic/sarcoplasmic reticulum (ER/SR) activates TMEM16A channels through interactions with regulatory proteins in vascular smooth muscle cells or endothelial cells. TMEM16A channel activation drives chloride efflux,
Fênix Araujo, Swapnil K. Sonkusare
wiley   +1 more source

Role of proaggregatory and antiaggregatory prostaglandins in hemostasis. Studies with combined thromboxane synthase inhibition and thromboxane receptor antagonism

, 1987
Thromboxane synthase inhibition can lead to two opposing effects: accumulation of proaggregatory cyclic endoperoxides and increased formation of antiaggregatory PGI2 and PGD2.
G Pieters, Vermylen, Jozef, Hans Deckmyn, Huybrechts, Lucien, J Arnout, P Gresele, Paolo Gresele, H Deckmyn, Deckmyn, Hans, Griet Pieters, Arnout, Jozef, Jos Vermylen, Erwin Huybrechts, E Huybrechts, Jef Arnout, J Vermylen, Gresele, P., Pieters, G.   +17 more
core   +1 more source

Thromboxane synthase expression co-localizes with infiltrating macrophages in renal allograft biopsies [PDF]

, 1995
Thromboxane synthase (TS) catalyzes the formation of the eicosanoid thromboxane (TxA2), which is a potent vasoconstrictor and activator of platelet aggregation.
Croker, Byron P., Byron P. Croker, Berkes, Eva A., Barri, Yousri M., Eva A. Berkes, Ramos, Eleanor L., Yousri M. Barri, Eleanor L. Ramos, Wilcox, Christopher S., John C. Peterson, Christopher S. Wilcox, Peterson, John C.   +11 more
core   +1 more source

Genome-wide association study implicates the role of TBXAS1 in the pathogenesis of depressive symptoms among the Korean population

Translational Psychiatry
Although depression is an emerging disorder affecting many people worldwide, most genetic studies have been performed in European descent populations.
Kyungtaek Park, Ah Ra Do, Yuree Chung, Min Ji Kim, Sang Jin Rhee, Dae Hyun Yoon, Seung Ho Choi, Sung Joon Cho, Han-Na Kim, Yong Min Ahn, Sungho Won   +10 more
doaj   +1 more source

VASCULAR AGING IN WOMEN: IS ESTROGEN THE FOUNTAIN OF YOUTH?

Frontiers in Physiology, 2012
Aging is a physiological process associated with structural and functional changes in vasculature, including endothelial dysfunction, arterial stiffening and remodeling, impaired angiogenesis, and defective vascular repair, and with an increasing ...
Susana eNovella, Susana eNovella, Ana Paula eDantas, Gloria eSegarra, Gloria eSegarra, Pascual eMedina, Pascual eMedina, Carlos eHermenegildo, Carlos eHermenegildo   +8 more
doaj   +1 more source

Calcium‐activated chloride channels in pericytes and their role in regulating organ blood flow

The Journal of Physiology, EarlyView.
Abstract figure legend Pericytes are microvascular mural cells with diverse roles. Contractile pericytes directly regulate local perfusion, while non‐contractile pericytes coordinate upstream vascular contractility via propagating electrical signals.
Paolo Tammaro, Hikaru Hashitani
wiley   +1 more source