Results 81 to 90 of about 113,969,313 (213)

Xenotransplantation of the Porcine Lung—From Immunological Barriers to Emerging Experimental Strategies

Xenotransplantation, Volume 33, Issue 5, September/October 2026.
ABSTRACT Lung transplantation is the only long‐lasting life‐saving treatment for patients with end‐stage pulmonary disease, but the ever‐growing shortage of suitable donor organs leads to high mortality rates of the afflicted patients. Xenotransplantation, the transplantation of organs across species, has emerged as a promising alternative. This review
Nathalie Roters, Niveditha Varma, Robert Ramm, Heiner Niemann, Patrick Zardo, Arjang Ruhparwar, Tobias Goecke   +6 more
wiley   +1 more source

Structure determination and comparison of BM567, a sulfonylurea, with terbogrel, two compounds with dual action, thromboxane receptor antagonism and thromboxane synthase inhibition

, 2001
BM567, a sulfonylurea compound - whose crystal structure is here discussed - and terbogrel, are both thromboxane receptor antagonists and thromboxane synthase inhibitors.
Delarge, Jacques, Rolin, Stéphanie, Wouters, Johan; id_orcid, Michaux, Catherine; id_orcid, Masereel, Bernard, Dogné, Jean-Michel, Durant, François   +6 more
core   +1 more source

Arachidonic acid intake promotes hypertension and target-organ fibrosis through CYP4A-mediated 20-HETE overproduction: Integrated evidence from human and animal studies

Clinical and Experimental Hypertension
The unregulated use of highly purified arachidonic acid (AA) supplements among Chinese fitness enthusiasts raises concerns about cardiovascular safety. To evaluate these risks, we integrated population-based, genetic, and experimental evidence.
Zhongzheng Zhou, Qinghua Fang, Xingyu Li, Chaohong Li, Jing Huang   +4 more
doaj   +1 more source

Investigation of thromboxane A2 synthase knockout mice

, 2007
Thromboxane A2合成酶(TXA2 synthase)所生產的TXA2具有引發血小板凝集、血管收縮及調節腎臟等功能，且在包含心肌梗塞、中風、氣喘及許多的腎臟疾病發生的過程中均扮演重要的角色。除了參與眾所周知的凝血與血栓形成外，TXA2被認為可能參與血小板生成及淋巴球的分化。為了進一步了解其生理功能，本論文以基因轉殖的方式製作TXA2合成酶基因剔除(TXAS-/-)小鼠模式。分析結果發現TXAS-/-小鼠具有正常的骨髓巨核細胞，其胸腺及脾臟的淋巴球數量也正常。但其出血時間異常且以花生四烯酸 ...
Yu, I-Shing, 游益興
core  

Thromboxane A2 inhibition of SKCa after NO synthase block in rat middle cerebral artery [PDF]

, 2007
NO/prostanoid independent, EDHF-mediated hyperpolarization and dilation in rat middle cerebral arteries is mediated solely by endothelial cell IK(Ca). However, when the NO-pathway is also active, both SK(Ca) and IK(Ca) contribute to EDHF responses.
Garland, Christopher, C J Garland, Garland, C. J., McNeish, Alister, McNeish, AJ, A J McNeish, Garland, CJ   +6 more
core   +1 more source

EP3 Blockade Adds to the Effect of TP Deficiency in Alleviating Endothelial Dysfunction in Atherosclerotic Mouse Aortas

Frontiers in Physiology, 2019
Endothelial dysfunction, which leads to ischemic events under atherosclerotic conditions, can be attenuated by antagonizing the thromboxane-prostanoid receptor (TP) that mediates the vasoconstrictor effect of prostanoids including prostacyclin (PGI2 ...
Chuangjia Hu, Bin Liu, Yineng Xu, Xiangzhong Wu, Tingting Guo, Yingzhan Zhang, Jing Leng, Jiahui Ge, Gang Yu, Jinwei Guo, Yingbi Zhou   +10 more
doaj   +1 more source

The role of prostacyclin synthase and thromboxane synthase signaling in the development and progression of cancer

, 2010
Prostacyclin synthase and thromboxane synthase signaling via arachidonic acid metabolism affects a number of tumor cell survival pathways such as cell proliferation, apoptosis, tumor cell invasion and metastasis, and angiogenesis. However, the effects of
O\u27BYRNE, KEN, REYNOLDS, JOHN, PIDGEON, GRAHAM   +2 more
core  

Quantification du thromboxane B2 par CLHP-ESI-SM • Application à des microsomes de levure exprimant la thromboxane synthase humaine

, 2009
Le but de cette étude était de mettre au point une méthode rapide, sensible et spécifique de quantification du thromboxane B2 (TXB2) par chromatographic liquide haute performance couplée à une interface d'ionisation électrospray et à une détection par ...
Christelle Cauffiez, Michel Lhermitte, Dany Chevalier, Franck Broly, Luc Humbert, Jean-Marc Lo-Guidice, Delphine Allorge, Michel Imbenotte, Florian Klinzig, Bernard Cartigny   +9 more
core   +1 more source

Positive effect of low-activity thromboxane A synthase 1 gene on prognosis in coronary heart disease

Терапевтический архив, 2015
Aim. To analyze the influence of pharmacogenetic factors on the risk of clopidogrel resistance and cardiovascular events during 18-months follow-up. Subjects and methods. Two hundred and fifty patients taking clopidogrel were examined.
F Yu Kopylov, D F Mesitskaya, Yu M Nikitina, M G Aksenova, A V Dobrovolsky, O V Lomakin, O V Chernyi   +6 more
doaj  

Sex differences in middle cerebral artery reactivity and hemodynamics independent from changes in systemic arterial stiffness in Sprague–Dawley rats

Physiological Reports
The mechanisms of sex differences in cerebrovascular function are not well understood. In this study, we determined whether sex differences in middle cerebral artery (MCA) reactivity are accompanied with changes in cerebral or systemic arterial ...
Jonathan W. Ray, Xuming Sun, Nildris Cruz‐Diaz, Victor M. Pulgar, Liliya M. Yamaleyeva   +4 more
doaj   +1 more source