Results 91 to 100 of about 113,969,313 (213)

GLP-1 Relaxes Rat Coronary Arteries by Enhancing ATP-Sensitive Potassium Channel Currents

Cardiology Research and Practice, 2019
GLP-1 is a new type of antidiabetic agent that possesses many beneficial effects. Although its cardiovascular actions have been widely examined, little is known about GLP-1’s effects on the rat coronary artery (RCA) or about the mechanisms underpinning ...
Qian-Feng Xiong, Shao-Hua Fan, Xue-Wen Li, Yu Niu, Jing Wang, Xin Zhang, Yi-Fan Chen, Ya-Wei Shi, Li-Hui Zhang   +8 more
doaj   +1 more source

Pharmacology of airways and vessels in lung slices in situ: role of endogenous dilator hormones

Respiratory Research, 2006
Small airway and vessels play a critical role in chronic airway and pulmonary vascular diseases, but their pharmacology has not been well characterised.
Barnes PJ, Sturton G, Faro R, Harrington L, Perez-Vizcaino F, Moreno L, Mitchell JA   +6 more
doaj   +1 more source

Effect of baicalin on gestational hypertension-induced vascular endothelial cell damage

Journal of International Medical Research, 2020
Objective Baicalin is a compound extracted from the dried root of Scutellaria baicalensis Georgi. Studies have shown that baicalin has a protective effect on vascular endothelial cells, but whether baicalin could alleviate ascular endothelial cell damage
Yang Liu, Miao Xiong, Fangfang Zhou, Nana Shi, Yunbin Jia   +4 more
doaj   +1 more source

Design, synthesis and biological evaluation of a sulfonylcyanoguanidine as thromboxane A₂ receptor antagonist and thromboxane synthase inhibitor

, 2001
The synthesis and the structure of N-isopropyl-N′-[2-(3′-methylphenylamino)-5-nitrobenzenesulfonyl] urea (14) was drawn from two thromboxane A2 receptor antagonists structurally related to torasemide.
Wouters, J; id_orcid, Rolin, S, Delarge, J, Pochet, L; id_orcid, Durant, F, Masereel, B, Dogné, Jean-Michel, Michaux, C; id_orcid   +7 more
core   +1 more source

Genome-wide transcriptome analysis and drug target discovery reveal key genes and pathways in thyroid cancer metastasis

Frontiers in Endocrinology
IntroductionMetastasis is the major cause of thyroid cancer morbidity and mortality. However, the mechanisms are still poorly understood. MethodsWe performed genome-wide transcriptome analysis comparing gene expression profile of metastatic thyroid ...
Minjing Zou, Amal Qattan, Monther Al-Alwan, Hazem Ghebeh, Naif Binjumah, Latifa Al-Haj, Khalid S. A. Khabar, Abdulmohsen Altaweel, Falah Almohanna, Abdullah M. Assiri, Abdelilah Aboussekhra, Ali S. Alzahrani, Ali S. Alzahrani, Yufei Shi   +13 more
doaj   +1 more source

Development of a PCR method for detection of thromboxane synthase gene / Roihanah Rahmat [PDF]

, 2009
Thromboxane synthase gene (TBXAS 1), converts prostaglandin H2 into thromboxane A2, a potent vasoconstrictor and inducer of platelet aggregation. Thromboxane A2 has been implicated in modulating cell cytotoxicity tumor growth and metastasis.
Rahmat, Roihanah
core  

Pharmacokinetic and pharmacodynamic studies following single and multiple doses of rolafagrel, a novel inhibitor of thromboxane synthase, in normal volunteers

, 1994
The pharmacokinetics and pharmacodynamics of rolafagrel (FCE 22178), a novel thromboxane synthase inhibitor, were evaluated after single and multiple oral doses in eight healthy volunteers.
PERUCCA, EMILIO, GATTI, GIULIANA, A. Bartoli, M. Strolin Benedetti, D. Bertin   +4 more
core   +1 more source

Endogenous prostaglandin endoperoxides may alter infarct size in the presence of thromboxane synthase inhibition: studies in a rabbit model of coronary artery occlusion-reperfusion

, 1993
Objectives. The aim of this study was to assess whether prostaglandin endoperoxides, which continue to be formed in the setting of thromboxane A2 synthase inhibition, might influence the fate of ischemic myocardium in a model of coronary occlusion and ...
VILLARI B, FOCACCIO A, DE CLERK F, CHIARIELLO M., AMBROSIO G, RAGNI M, PACE, LEONARDO, PACE L, DECLERK F, CONDORELLI M, GOLINO P, GOLINO, Paolo   +11 more
core  

Genomic, Lipidomic and Metabolomic Analysis of Cyclooxygenase-null Cells: Eicosanoid Storm, Cross Talk, and Compensation by COX-1

Genomics, Proteomics & Bioinformatics, 2016
The constitutively-expressed cyclooxygenase 1 (COX-1) and the inducible COX-2 are both involved in the conversion of arachidonic acid (AA) to prostaglandins (PGs). However, the functional roles of COX-1 at the cellular level remain unclear.
Abul B.M.M.K. Islam, Mandar Dave, Sonia Amin, Roderick V. Jensen, Ashok R. Amin   +4 more
doaj   +1 more source

Probing Ligand Binding to Thromboxane Synthase

, 2016
Various fluorescence experiments and computer simulations were utilized to gain further understanding of thromboxane A2 synthase (TXAS), which catalyzes an isomerization of prostaglandins H2 to give rise to thromboxane A2 along with a fragmentation ...
Hsiao-Ching Yang (1656388), Tai-An Pan (1994161), Steven Chun-Wei Chou (1994164), Jinn-Shyan Wang (1656403), Lee-Ho Wang (1994167), Wei-Chih Chao (1656394), Pi-Tai Chou (1282068), Jyh-Feng Lu (1656412)   +7 more
core   +1 more source