Results 21 to 30 of about 563,890 (226)

Effects of AT1 Receptor Blockade on Plasma Thromboxane A2 (TXA2) Level and Skin Microcirculation in Young Healthy Women on Low Salt Diet

Kidney & Blood Pressure Research, 2013
Objective: To determine the effect of AT1 receptor antagonism on skin microcirculation and plasma level of thromboxane A2 (TXA2). Methods: Healthy women (n=20) maintained 7 days low salt (LS) diet (intake 2 metabolite thromboxane B2 (TXB2) and plasma ...
Ana Cavka, Anita Cosic, Ivana Grizelj, Akos Koller, Bojan Jelaković, Julian H Lombard, Shane A Phillips, Ines Drenjancevic   +7 more
doaj   +1 more source

Stability of thromboxane in blood samples. [PDF]

, 2019
To access publisher's full text version of this article, please click on the hyperlink in Additional Links field or click on the hyperlink at the top of the page marked DownloadIntroduction: Conventional venous blood collection requires a puncture with a
Ólafsson, Ísleifur, Andersen, Karl, Andersen, Karl Konráð, Ólafsson, Ísleifur Hákon, Helgadóttir, Helga, Gizurarson, Sveinbjörn   +5 more
core   +1 more source

Menthol Modulates Pacemaker Potentials through TRPA1 Channels in Cultured Interstitial Cells of Cajal from Murine Small Intestine

Cellular Physiology and Biochemistry, 2016
Background/Aims: ICCs are the pacemaker cells responsible for slow waves in gastrointestinal (GI) smooth muscle, and generate periodic pacemaker potentials in current-clamp mode.
Hyun Jung Kim, Jinhong Wie, Insuk So, Myeong Ho Jung, Ki-Tae Ha, Byung Joo Kim   +5 more
doaj   +1 more source

Thromboxane Mobilizes Insect Blood Cells to Infection Foci

Frontiers in Immunology, 2021
Innate immune responses are effective for insect survival to defend against entomopathogens including a fungal pathogen, Metarhizium rileyi, that infects a lepidopteran Spodoptera exigua.
Miltan Chandra Roy, Kiwoong Nam, Jaesu Kim, David Stanley, Yonggyun Kim   +4 more
doaj   +1 more source

The putative mechanisms underlying testosterone and cardiovascular risk [v1; ref status: indexed, http://f1000r.es/374]

F1000Research, 2014
The use of testosterone supplementation therapy (TST) is increasing primarily in men with symptomatic hypogonadism. While TST has been shown to have numerous benefits, as its use increases, the role on cardiovascular health must be explored.
Avinash Maganty, Jason R. Kovac, Ranjith Ramasamy   +2 more
doaj   +1 more source

Inhibition of Female and Male Human Detrusor Smooth Muscle Contraction by the Rac Inhibitors EHT1864 and NSC23766

Frontiers in Pharmacology, 2020
IntroductionLower urinary tract symptoms (LUTS) due to overactive bladder (OAB) are caused by spontaneous detrusor contractions. Medical treatment with muscarinic receptor antagonists or β3-adrenoceptor agonists aims to inhibit detrusor contractions, but
Bingsheng Li, Qingfeng Yu, Ruixiao Wang, Christian Gratzke, Christian Gratzke, Xiaolong Wang, Annabel Spek, Annika Herlemann, Alexander Tamalunas, Frank Strittmatter, Raphaela Waidelich, Christian G. Stief, Martin Hennenberg   +12 more
doaj   +1 more source

Pharmacology of the Thromboxane Receptor Antagonist and Thromboxane Synthase Inhibitor BM‐531 [PDF]

Cardiovascular Drug Reviews, 2001
ABSTRACTBM‐531 (N‐tert‐butyl‐N'‐[(2‐cyclohexylamino‐5‐nitrobenzene)sulfonyl]urea), a torasemide derivative, is a novel noncarboxylic thromboxane receptor antagonist and thromboxane synthase inhibitor. Indeed, its affinity for human washed platelet TXA2receptors labeled with [3H]SQ‐29548 (IC50= 0.0078 μM) is higher than sulotroban (IC50= 0.93 μM) and SQ‐
J M, Dogné, S, Rolin, X, de Leval, P, Benoit, P, Neven, J, Delarge, P, Kolh, J, Damas, J L, David, B, Masereel   +9 more
openaire   +2 more sources

Characterization of signalling cross-talk between the EP2 and FP receptors in endometrial epithelial cells [PDF]

, 2009
Uterine fibroids are benign tumors that arise from the smooth-muscle uterine cells (myometrium) and are the most common uterine disorder occurring in as many as 30% of women over 35 years of age. Despite their frequent occurrence, the etiology of uterine
Abera, Aron Berhanie
core   +1 more source

New analogues of 13-hydroxyocatdecadienoic acid and 12-hydroxyeicosatetraenoic acid block human blood platelet aggregation and cyclooxygenase-1 activity

Chemistry Central Journal, 2012
Background Thromboxane A2 is derived from arachidonic acid through the action of cyclooxygenases and thromboxane synthase. It is mainly formed in blood platelets upon activation and plays an important role in aggregation. Aspirin is effective in reducing
Hirz Taghreed, Khalaf Ali, El-Hachem Nehme, Mrad May F, Abdallah Hassan, Créminon Christophe, Grée René, Merhi Raghida Abou, Habib Aïda, Hachem Ali, Hamade Eva   +10 more
doaj   +1 more source

Regulation of the tumor suppressor FOXO3 by the thromboxane-A2 receptors in urothelial cancer. [PDF]

PLoS ONE, 2014
The transcription factor FOXO3 is a well-established tumor suppressor whose activity, stability, and localization are regulated by phosphorylation and acetylation.
Philip M Sobolesky, Perry V Halushka, Elizabeth Garrett-Mayer, Michael T Smith, Omar Moussa   +4 more
doaj   +1 more source