Results 11 to 20 of about 286,478 (209)

Increased Thromboxane A₂ Levels in Pulmonary Artery Smooth Muscle Cells Isolated from Patients with Chronic Obstructive Pulmonary Disease [PDF]

Medicina, 2023
Introduction: Pulmonary hypertension due to chronic obstructive pulmonary disease (COPD) is classified as Group 3 pulmonary hypertension, with no current proven targeted therapies.
Abdullah A. Alqarni
doaj   +3 more sources

Stability of thromboxane in blood samples [PDF]

Vascular Health and Risk Management, 2019
Helga Helgadóttir,1,2 Ísleifur Ólafsson,2 Karl Andersen,3 Sveinbjörn Gizurarson11Faculty of Pharmaceutical Sciences, University of Iceland, Reykjavik, Iceland; 2Department of Clinical Biochemistry, Landspitali University ...
Helgadóttir H, Ólafsson Í, Andersen K, Gizurarson S   +3 more
doaj   +2 more sources

Inhibiting breast cancer by targeting the thromboxane A2 pathway

npj Precision Oncology, 2017
Breast cancer: Pathway target identified The identification of a signaling pathway connected to the progression of breast cancer could prove a valuable therapeutic target.
Haitao Li, Mee-Hyun Lee, Kangdong Liu, Ting Wang, Mengqiu Song, Yaping Han, Ke Yao, Hua Xie, Feng Zhu, Michael Grossmann, Margot P. Cleary, Wei Chen, Ann M. Bode, Zigang Dong   +13 more
doaj   +2 more sources

Physiological Significance of Thromboxane A2 Receptor Dimerization

Journal of Pharmacological Sciences, 2006
.: The thromboxane A2 receptor (TP), one of the G protein-coupled receptors (GPCRs), consists of two splicing variants, TPα and TPβ, which differ in their C-terminal regions.
Masako Sasaki, Katsutoshi Miyosawa, Satoko Ohkubo, Norimichi Nakahata   +3 more
doaj   +2 more sources

Structural and dynamic insights into agonist recognition and function of the thromboxane A2 receptor [PDF]

Nature Communications
The thromboxane A2 receptor (TP), expressed in platelets and smooth muscle, plays an important role in blood clotting and muscle contraction. The endogenous ligand of this G protein-coupled receptor (GPCR), thromboxane A2 (TXA2), is a short-lived ...
Pawel Krawinski, Donna Matzov, Aoife Ryder, Kanhaya Lal, Dmitry S. Karlov, Georges Chalhoub, Eamon P. Mulvaney, B. Therese Kinsella, Peter J. McCormick, Martin Caffrey, Irina G. Tikhonova, Moran Shalev-Benami   +11 more
doaj   +2 more sources

Thromboxane A2 or Activated Platelets Slightly Lower Fgf23 Expression in vitro

Kidney & Blood Pressure Research
Introduction: Fibroblast growth factor 23 (FGF23) has emerged as an important endocrine regulator of renal phosphate and vitamin D metabolism and as a factor implicated in pathophysiological processes in further organs, including the heart. In
Elena Kohm, Steffen Rausch, Julia Vogt, Martina Feger, Michael Föller   +4 more
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Centrally administered thromboxane A2 analogue facilitates the micturition reflex in rats [PDF]

Scientific Reports
The lower urinary tract stores and periodically eliminates urine, which is regulated by the peripheral and central nervous system (CNS). Thromboxane A₂ (TxA2), an arachidonic acid metabolite known for platelet aggregation, is a neuromodulator exciting ...
Chisato Hamada, Takahiro Shimizu, Mio Togo, Youichirou Higashi, Nobutaka Shimizu, Junichi Furumiya, Motoaki Saito   +6 more
doaj   +2 more sources

Synthesis of thromboxane A2 analogues. [PDF]

The aim of the project was to synthesize novel thromboxane A2 analogues which would be potential thromboxane A2 antagonists. Three thromboxane A2 analogues were synthesized, methyl 7-[-5-(3-hydroxy-1-(E)-octenyl)-2-methylbicyclo[3.3.1]non-2-en-9-yl]-[syn]
Evans, Elizabeth Hannah.
core   +6 more sources

AZAPROSTANOID PROBES FOR THE THROMBOXANE A2/PROSTAGLANDIN H2 PLATELET RECEPTOR.

, 1986
AZAPROSTANOID PROBES FOR THE THROMBOXANE A2/PROSTAGLANDIN H2 PLATELET ...
KATHRYN ELIZABETH. SCHNORF (7971845)
core   +6 more sources

THE MECHANISM OF THROMBOXANE A2/PROSTAGLANDIN H2-INDUCED PLATELET ACTIVATION.

, 1982
THE MECHANISM OF THROMBOXANE A2/PROSTAGLANDIN H2-INDUCED PLATELET ...
LESLIE VICTORIA. PARISE (7964387)
core   +6 more sources