Results 51 to 60 of about 82 (78)

ChemInform Abstract: Improved Synthesis of Thromboxane A2 Receptor Antagonists (XI) with a Dibenzoxepin Ring System.

ChemInform, 1996
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
T. SUGAYA, N. KATO, A. SAKAGUCHI, S. TOMIOKA   +3 more
openaire   +1 more source

Oxidative CH Bond Functionalization and Ring Expansion with TMSCHN₂: A Copper(I)‐Catalyzed Approach to Dibenzoxepines and Dibenzoazepines

Angewandte Chemie International Edition, 2015
AbstractTricyclic dibenzoxepines and dibenzazepines are important therapeutic agents for the pharmaceutical industry and academic research. However, their syntheses are generally rather tedious, requiring several steps that involve a Wagner–Meerwein‐type rearrangement under harsh conditions.
Tobias, Stopka, Leyre, Marzo, Mercedes, Zurro, Simon, Janich, Ernst-Ulrich, Würthwein, Constantin G, Daniliuc, José, Alemán, Olga García, Mancheño   +7 more
openaire   +3 more sources

Dibenzoxepin derivatives: thromboxane A2 synthase inhibition and thromboxane A2 receptor antagonism combined in one molecule

Journal of Medicinal Chemistry, 1993
A new series of 6,11-dihydrodibenz[b,e]oxepin derivatives exerting both thromboxane synthase inhibitory (TXS-I) and thromboxane receptor antagonist (TXRA) activities is described. (-)-11-[(3-Pyridylmethyl)thio]-6,11-dihydrodibenz[b,e]oxepin -2- carboxylic acid [(-)-3] and (E)-11-[2-(3-pyridyl)ethylidene]-6,11-dihydrodibenz[b,e]oxepin+ ++-2- carboxylic ...
E, Ohshima, H, Sato, H, Obase, I, Miki, A, Ishii, M, Kawakage, S, Shirakura, A, Karasawa, K, Kubo   +8 more
openaire   +2 more sources

ChemInform Abstract: PHOTOUMLAGERUNG VON 9,10‐EPOXY‐9,10‐DIHYDROPHENANTHREN, SYNTH. VON 2,304,5‐DIBENZOXEPIN

Chemischer Informationsdienst, 1973
AbstractDas Epoxy‐dihydrophenanthren (I) lagert sich bei Belichtung (Ä = 254 nm) in Benzol‐Lösung in das Dibenzoxepin (II) um.
N. E. BRIGHTWELL, G. W. GRIFFIN
openaire   +1 more source

Dibenzepinones, dibenzoxepines and benzosuberones based p38α MAP kinase inhibitors: Their pharmacophore modelling, 3D-QSAR and docking studies

Computers in Biology and Medicine, 2019
In the present study, a series of dibenzepinones, dibenzoxepines, and benzosuberones targeting p38α MAP kinase were subjected to pharmacophore modelling, 3D-QSAR and molecular docking studies. The IC50 values for these 67 compounds ranged between 0.003 and 6.80 μM. A five-point model (DDHHR.8) was generated using these compounds.
Mohemmed Faraz Khan, Garima Verma, Perwez Alam, Mymoona Akhter, Md Afroz Bakht, Syed Misbahul Hasan, Mohammad Shaquiquzzaman, Mohammad Mumtaz Alam   +7 more
openaire   +2 more sources

Synthesis and anti-influenza virus activity of substituted dibenzoxepine-based baloxavir derivatives

European Journal of Medicinal Chemistry
Seasonal influenza poses a significant threat to global public health, driving the need for effective anti-influenza agents. The PA protein, which captures the pre-mRNA cap structure, is crucial for the replication of the influenza virus and serves as an important target for developing such agents.
Yongzhi Chen, Qifan Zhou, Fan Pan, Binhao Rong, Renwei Xiao, Yuanmei Wen, Jingyuan Song, Zhengchao Tu, Shuwen Liu, Yingjun Li, Xumu Zhang   +10 more
openaire   +2 more sources

Substituent effects in the induction of a cholesteric liquid crystal phase by atropisomeric dibenzoxepins: a study of arene–arene interactions

Chem. Commun., 1996
Substituent effects in the induction of a cholesteric liquid crystal phase by atropisomeric dibenzoxepins suggest that both electrostatic repulsion and polarizability are important factors controlling the stability of arene π-stacking complexes.
Vance E. Williams, Robert P. Lemieux
openaire   +1 more source

Three-Step Synthesis of (Thio)xanthene and Dibenzothiepine/Dibenzoxepine by an Intramolecular Mizoroki-Heck Reaction of Diaryl (Thio)Ethers

Synlett, 2012
We present a novel three-step protocol for preparing xanthene/thioxanthene and dibenzothiepine/dibenzoxepine from readily available starting materials. The Mizoroki―Heck cyclization as the final step was optimized to afford full conversion of the corresponding diaryl (thio)ethers and furthermore to achieve reasonably good selectivity between the 6-exo ...
Jepsen, Tue Heesgaard, Larsen, Mogens, Jørgensen, Morten, Nielsen, Mogens Brøndsted   +3 more
openaire   +2 more sources

Characterization of Thromboxane A2/Prostaglandin H2 Receptors in Porcine Coronary Artery -The Inhibitory Effect of a Novel Dibenzoxepin Derivative, KW-3635

Thrombosis and Haemostasis, 1992
SummaryWe characterized the thromboxane A2/prostaglandin H2 receptors in porcine coronary artery. The binding of [3H]SQ 29,548, a thromboxane A2 antagonist, to coronary arterial membranes was saturable and displaceable. Scatchard analysis of equilibrium binding showed a single class of high affinity binding sites with a dissociation constant of 18.5 ±1.
I, Miki, A, Ishii
openaire   +2 more sources

Selective Friedel–Crafts Acylation Reactions of 2-Arylphenoxyacetic Acids: A Simple and Efficient Methodology to Synthesize Dibenzoxepine and Arylcoumaranone Derivatives

Synthesis, 2015
Intramolecular Friedel–Crafts acylation reactions of 2-arylphenoxyacetic acids are accomplished using trifluoroacetic anhydride or trifluoromethanesulfonic acid at 0 °C or room temperature. Depending on the reaction conditions, dibenzoxepines or arylcoumaranones are obtained in good yields and with high selectivities (83–100%).
Zhizhong Sun, Wenyi Chu, Jialin Wang, Jiaqi Liu, Hao Lan   +4 more
openaire   +1 more source