Results 41 to 50 of about 76 (75)

Non-prostanoid thromboxane A2 receptor antagonists with a dibenzoxepin ring system. 2

Journal of Medicinal Chemistry, 1992
A series of 11-[2-(1-benzimidazolyl)ethylidene]-6,11-dihydrodibenz[b,e]oxep in-2- carboxylic acid derivatives and related compounds were synthesized and found to be potent TXA2/PGH2 receptor antagonists. Each compound synthesized was tested for its ability to displace [3H]U-46619 binding from guinea pig platelet TXA2/PGH2 receptors.
E, Ohshima, H, Takami, H, Sato, S, Mohri, H, Obase, I, Miki, A, Ishii, S, Shirakura, A, Karasawa, K, Kubo   +9 more
openaire   +2 more sources

Photorearrangement of 9,10-epoxy-9,10-dihydrophenanthrene. Synthesis of 2,3:4,5-dibenzoxepin

Journal of the Chemical Society, Chemical Communications, 1973
9,10-Dihydro-9,10-epoxyphenanthrene undergoes photorearrangement to 1,2:3,4-dibenzoxepin, an unknown oxepin, which was synthesized independently.
N. E. Brightwell, G. W. Griffin
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Synthesis of Trifluoromethylated Dibenzoxepines via Palladium-Catalyzed Tandem C–O Bond Formation/C–H Arylation

The Journal of Organic Chemistry, 2023
A palladium-catalyzed cyclization reaction of phenols with trifluoromethyl-containing ortho-bromo-β-chlorostyrenes has been developed. In the presence of palladium(II) acetate, tricyclohexylphosphine, and cesium carbonate, a variety of 6-trifluoromethyldibenzo[b,d]oxepines were prepared in moderate to good yields through the tandem O-alkenylation of ...
Zhi-Yi Zhao, Xing-Guo Zhang, Hai-Yong Tu
openaire   +2 more sources

Non-prostanoid thromboxane A2 receptor antagonists with a dibenzoxepin ring system. 1

Journal of Medicinal Chemistry, 1992
A series of 11-[[2-[(arylsulfonyl)amino]ethyl]thio]-6,11- dihydrodibenz[b,e]oxepin-2-carboxylic acids and related derivatives were synthesized. The compounds were tested for their antagonizing effects on guinea pig platelet TXA2/PGH2 receptors. Structure-activity relationships are discussed.
E, Ohshima, H, Takami, H, Sato, H, Obase, I, Miki, A, Ishii, A, Karasawa, K, Kubo   +7 more
openaire   +2 more sources

ChemInform Abstract: Total Synthesis of Cularine Alkaloids via Dibenzoxepines as Key Intermediates.

ChemInform, 1995
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
A. GARCIA, L. CASTEDO, D. DOMINGUEZ
openaire   +1 more source

Design, synthesis, cytotoxicities and DNA cleavage activities of dibenzoxepine and isoquinoline derivatives starting from dehydroabietylamine

Journal of Asian Natural Products Research, 2016
A series of novel hexahydrodibenzoxepine and quinazoline derivatives were designed and synthesized starting from dehydroabietylamine. The cytotoxicities of the compounds against L02 and HepG2 cell lines were investigated. Meanwhile, the plasmid DNA (Escherichia coli) cleavage of several heterocyclic derivatives was studied.
Chao-Xiang, Liu, Zhong-Xiang, Lin, Ai-Min, Zhou   +2 more
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ChemInform Abstract: Improved Synthesis of Thromboxane A2 Receptor Antagonists (XI) with a Dibenzoxepin Ring System.

ChemInform, 1996
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
T. SUGAYA, N. KATO, A. SAKAGUCHI, S. TOMIOKA   +3 more
openaire   +1 more source

Dibenzoxepin derivatives: thromboxane A2 synthase inhibition and thromboxane A2 receptor antagonism combined in one molecule

Journal of Medicinal Chemistry, 1993
A new series of 6,11-dihydrodibenz[b,e]oxepin derivatives exerting both thromboxane synthase inhibitory (TXS-I) and thromboxane receptor antagonist (TXRA) activities is described. (-)-11-[(3-Pyridylmethyl)thio]-6,11-dihydrodibenz[b,e]oxepin -2- carboxylic acid [(-)-3] and (E)-11-[2-(3-pyridyl)ethylidene]-6,11-dihydrodibenz[b,e]oxepin+ ++-2- carboxylic ...
E, Ohshima, H, Sato, H, Obase, I, Miki, A, Ishii, M, Kawakage, S, Shirakura, A, Karasawa, K, Kubo   +8 more
openaire   +2 more sources

Synthesis and anti-influenza virus activity of substituted dibenzoxepine-based baloxavir derivatives

European Journal of Medicinal Chemistry
Seasonal influenza poses a significant threat to global public health, driving the need for effective anti-influenza agents. The PA protein, which captures the pre-mRNA cap structure, is crucial for the replication of the influenza virus and serves as an important target for developing such agents.
Yongzhi Chen, Qifan Zhou, Fan Pan, Binhao Rong, Renwei Xiao, Yuanmei Wen, Jingyuan Song, Zhengchao Tu, Shuwen Liu, Yingjun Li, Xumu Zhang   +10 more
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Dibenzepinones, dibenzoxepines and benzosuberones based p38α MAP kinase inhibitors: Their pharmacophore modelling, 3D-QSAR and docking studies

Computers in Biology and Medicine, 2019
In the present study, a series of dibenzepinones, dibenzoxepines, and benzosuberones targeting p38α MAP kinase were subjected to pharmacophore modelling, 3D-QSAR and molecular docking studies. The IC50 values for these 67 compounds ranged between 0.003 and 6.80 μM. A five-point model (DDHHR.8) was generated using these compounds.
Mohemmed Faraz Khan, Garima Verma, Perwez Alam, Mymoona Akhter, Md Afroz Bakht, Syed Misbahul Hasan, Mohammad Shaquiquzzaman, Mohammad Mumtaz Alam   +7 more
openaire   +2 more sources