Results 161 to 170 of about 4,128 (229)

Ca2+-Stimulated Mitochondrial Reactive Oxygen Species Generation and Permeability Transition Are Inhibited by Dibucaine or Mg2+

Archives of Biochemistry and Biophysics, 1998
Alicia J Kowaltowski, Roger F Castilho
exaly   +2 more sources

Mechanism of dibucaine-induced apoptosis in promyelocytic leukemia cells (HL-60)

Biochemical Pharmacology, 2000
Toshihiko Utsumi
exaly   +2 more sources

Simultaneous determination of dibucaine and naphazoline in human serum by monolithic silica spin column extraction and liquid chromatography–mass spectrometry

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, 2008
Takeshi Saito
exaly   +2 more sources

Identification of dibucaine derivatives as novel potent enterovirus 2C helicase inhibitors: In vitro, in vivo, and combination therapy study.

European journal of medicinal chemistry, 2020
Enterovirus A71 (EV-A71) is a human pathogen causing hand, foot and mouth disease (HFMD) which seriously threatened the safety and lives of infants and young children. However, there are no licensed direct antiviral agents to cure the HFMD. In this study,
Qi Tang, Zhichao Xu, Mengyun Jin, T. Shu, Yinuo Chen, Leilei Feng, Qiuhan Zhang, K. Lan, Shuwen Wu, Hai-Bing Zhou   +9 more
semanticscholar   +1 more source

Charge- and pH-dependent binding sites for dibucaine in ionic micelles: a fluorescence study

Biochimica Et Biophysica Acta - Biomembranes, 1994
S. Louro, O. Nascimento, M. Tabak
exaly   +2 more sources

Pre-clinical evaluation of new dibucaine formulations for preventive analgesia

Journal of liposome research, 2020
We have previously developed ammonium sulphate gradient loaded liposomes to encapsulate dibucaine. Thus, the purpose of this study was to evaluate the pre-clinical safety and effectiveness of this novel ionic liposomal formulation of dibucaine (DBC), as ...
B. Furlan, Beatriz T. de Melo, J. Papini, M. Sperandio, J. Oliveira, E. de Paula, C. Cereda, G. Tófoli   +7 more
semanticscholar   +1 more source

Electron Paramagnetic Resonance and Small-Angle X-ray Scattering Characterization of Solid Lipid Nanoparticles and Nanostructured Lipid Carriers for Dibucaine Encapsulation.

Langmuir, 2018
Dibucaine (DBC) is one of the most potent long-acting local anesthetics, but it also has significant toxic side effects and low water solubility. Solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs) have been proposed as drug ...
R. Barbosa, B. R. Casadei, E. L. Duarte, P. Severino, Leandro R. S. Barbosa, N. Durán, E. de Paula   +6 more
semanticscholar   +1 more source

Phentolamine Reverses Epinephrine-Enhanced Skin Antinociception of Dibucaine in Rats.

Anesthesia and Analgesia, 2019
BACKGROUND The objective of the experiment was to assess the antinociceptive effect of dibucaine, bupivacaine, and epinephrine. To assess the mechanism of action of the interaction between dibucaine and epinephrine, phentolamine, a nonselective α ...
An-Kuo Chou, C. Chiu, Yu-Wen Chen, Jhi-Joung Wang, C. Hung   +4 more
semanticscholar   +1 more source

Fatal Accidental Dibucaine Poisoning in Children

Annals of Emergency Medicine, 1996
Dibucaine is a potent amide anesthetic available in over-the-counter preparations. Compared with lidocaine, substantially lower doses of dibucaine may result in seizures, dysrhythmias, and death. We present three fatal cases of accidental dibucaine ingestion in children and discuss the toxicity, treatment, and prevention of such ingestions.
P S, Dayan, T L, Litovitz, B I, Crouch, A J, Scalzo, B L, Klein   +4 more
openaire   +2 more sources

Inhibition of cytochrome oxidase by dibucaine

Biochemical Pharmacology, 1990
Dibucaine-HCl inhibited mitochondrial cytochrome c oxidase activity in intact mitochondria with 50% inhibition occurring at 1.1 mM dibucaine-HCl. Dibucaine-HCl did not prevent the reduction of cytochrome oxidase by ascorbate plus N,N,N',N'-tetramethyl-p-phenylenediamine dihydrochloride (TMPD) when measured at 604 nm but prevented 50% of the absorbance ...
B K, Stringer, H J, Harmon
openaire   +2 more sources